Inhibition of histidine kinase signal sensing: a novel paradigm for antimicrobial development

组氨酸激酶信号传感的抑制：抗菌药物开发的新范例

• 批准号: nhmrc : 511206
• 负责人: E/Pr Jules Guss
• 金额: $ 30.95万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-histidine-kinase-antimicrobial-development/97823
• 关键词: Inhibition; histidine; kinase; signal; sensing

Staphylococcus aureus (Golden staph) has been termed a superbug because of its remarkable ability to acquire resistance to virtually all antibiotics. Until recently, Golden Staph infections were almost always acquired in hospitals, but the increasing incidence of community-acquired S. aureus infections has rendered it a major public health threat in Australia. The aim of this research is to develop antimicrobial agents to combat antibiotic-resistant strains of Staphylococcus aureus.

金黄色葡萄球菌（金黄色葡萄球菌）被称为超级细菌，因为它具有对几乎所有抗生素产生耐药性的显著能力。直到最近，金黄色葡萄球菌感染几乎总是在医院获得，但社区获得性S。金黄色葡萄球菌感染已使其成为澳大利亚的主要公共卫生威胁。本研究的目的是开发抗微生物剂来对抗金黄色葡萄球菌的耐药菌株。