Transcriptional complexes in haematopoiesis and T-cell Leukemia

儿童T细胞白血病的预后很差。我们正在以原子级别的精度确定LMO2(也与前列腺癌和其他癌症有关)和TAL1及其结合伙伴对正常血细胞发育和T细胞白血病的作用。有了这些信息，我们正在开发可用于破坏致病复合体的试剂，这将导致白血病和其他癌症的新的、特异的治疗方法的开发。

Childhood T-cell leukemias have a poor prognosis for recovery. We are determining, with atomic level precision, how the proteins LMO2 (also linked to prostate and other cancers) and Tal1, and their binding partners contribute to both normal blood cell development and T-cell leukemia. With this information we are developing reagents that can be used to disrupt disease-causing complexes, and which will lead towards the development of new, specific, therapeutics for leukemias and other cancers.