Maryland Prostate Cancer Case-Control Study

马里兰州前列腺癌病例对照研究

• 批准号: 8763120
• 负责人: Stefan Ambs
• 金额: $ 58.33万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8763120
• 关键词: Academic Medical Centers; Address; African American; Age; American; Area; Baltimore; Biological; Blood; Cancer Patient; Case-Control Studies; Chronic; Cities; Collaborations; Collection; Contractor; Data; Databases; Development; Diet; Dietary Factors; Eligibility Determination; Enrollment; Epidemiologic Studies; Epidemiology; Ethnic Origin; European; Exposure to; Freezing; Frequencies; Future; Gene Expression; Genetic; Genetic Variation; Goals; Hereditary Malignant Neoplasm; Home environment; Individual; Inflammation; Joints; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Maryland; Medical; Medical center; Minor; Molecular; Molecular Epidemiology; Molecular Profiling; Motor Vehicles; Operative Surgical Procedures; Paraffin Embedding; Participant; Patients; Pharmaceutical Preparations; Phase; Pilot Projects; Policies; Population; Population Group; Procedures; Prostate; Prostatectomy; Prostatic Neoplasms; Protocols documentation; Questionnaires; Race; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Resected; Resources; Risk Factors; Sampling; Sexually Transmitted Diseases; Socioeconomic Status; Specimen; Study Subject; Surveys; Testing; Tissue Sample; Tissues; Tobacco; Tobacco use; Translational Research; Tumor Biology; Universities; Urine; Veterans Hospitals; Virus Diseases; Work; cancer health disparity; cancer risk; case control; data sharing; design; disorder risk; ethnic difference; health disparity; indexing; male; men; population based; seal; tumor; web site

The greater Baltimore area in Maryland has a large population of African-Americans and European-Americans, which makes this area most suitable to investigate differences in the exposure to prostate cancer risk factors among these two population groups. We designed a study that will use an integrated molecular epidemiology and translational research approach to examine causes for the excessive burden of prostate cancer among African-American men, including the study of tumor biological differences between African-American and European-American patients, supported by the collection of blood, urine, tissue samples, and survey data. Other epidemiological studies of prostate cancer have been established in recent years; however, only a few of these studies address the need for health disparity research and will have the opportunity to collect fresh-frozen tumor specimens from case subjects. Our study was implemented in two phases. The first phase, which started in April of 2005, constituted a pilot study to evaluate recruitment procedures. This phase was successful and the full study was initiated with minor changes to the protocol in April of 2006. Study participants will be African-American and European-American males who reside in Baltimore city and surrounding areas. The study will recruit 1000 prostate cancer cases and 1000 population-based controls, with recruitment ending in 2015. The cases are recruited at two Baltimore hospitals, the Veterans Affairs Medical Center and the University of Maryland Medical Center. Cases will have pathologically confirmed prostate cancer. The population-based controls are identified through the Maryland Department of Motor Vehicles database, and are frequency-matched by age and race to cases. The study involves the administration of two questionnaires and collection of blood and urine from all study subjects. Fresh-frozen tumor specimens will be obtained from cancer patients if available after prostatectomy. The study survey evaluates tobacco use, medication use, diet, medical and sexual history, familial cancer history, and socioeconomic status. The study is supported by an epidemiological infrastructure that has been developed by our resource contractor at the University of Maryland for a lung cancer case-control study. This lung cancer study is ongoing, and the controls that are recruited for the prostate cancer study are joint controls with the lung cancer study. Hence, population-based male controls recruited by our contractor have double eligibility for the concurrent lung and prostate cancer studies. To achieve an age and race matching of cases and controls in the prostate study, we will over-sample for male controls in the lung cancer study. This study and the ongoing lung study are described by a recently established website at (http://home.ccr.cancer.gov/GEMES/index.html). The website also describes the policy for collaborations involving data sharing. Study protocol and the two questionnaires can be accessed at: http://www3.cancer.gov/intra/lhc/Ambs/Prostate_Cancer_Case_Control_Study_Protocol.pdf http://www3.cancer.gov/intra/lhc/Ambs/Lung_Prostate_Case_Control_Questionnaire.pdf http://www3.cancer.gov/intra/lhc/Ambs/Prostate_Cancer_Supplementary Questionnaire.pdf Our study is aimed at identifying differences in risk factor exposure and tumor biology between African-American and European-American men. We will also test the hypothesis that environmental and genetic factors and their interactions contribute to the existing prostate cancer health disparity among African-Americans and European-Americans. Molecular work will be used to examine race/ethnic differences in tumor biology. Currently, we have enrolled 816 cases (429 European-Americans and 387 African-Americans) and 767 population-based controls (466 European-Americans and 301 African-Americans) and have collected blood and urine from these individuals. We have also collected paraffin-embedded and fresh-frozen tissue specimens form 127 prostatectomy surgeries. Future recruitment rates are set at 50-100 cases and 50-100 controls per year until the recruitment sealing of 500 African-American and 500 European-American cases and 500 African-American and 500 European-American controls is reached.

马里兰州的大巴尔的摩地区拥有大量的非裔美国人和欧洲裔美国人，这使该地区最适合研究这两个人群中前列腺癌危险因素的差异。我们设计了一项研究，该研究将使用综合分子流行病学和转化研究方法来研究非裔美国人男性前列腺癌负担过大负担的原因，包括研究非裔美国人和欧美患者之间肿瘤生物学差异的研究，并取决于血液，尿液，尿液，组织样本和调查数据的收集。近年来已经建立了对前列腺癌的其他流行病学研究。但是，其中只有少数研究涉及对健康差异研究的需求，并将有机会从病例受试者那里收集新鲜冻结的肿瘤标本。我们的研究分为两个阶段。第一阶段始于2005年4月，构成了一项试点研究，以评估招聘程序。这一阶段是成功的，整个研究是在2006年4月开始对该方案进行了微小变化的。研究参与者将是居住在巴尔的摩市及周边地区的非裔美国人和欧洲男性。该研究将招募1000例前列腺癌病例和1000例基于人群的控制，并于2015年结束招聘。该病例是在两家巴尔的摩医院，退伍军人事务医疗中心和马里兰大学医学中心招募的。病例将有病理确认的前列腺癌。基于人群的控件是通过马里兰州汽车数据库确定的，并且按年龄和竞赛频率与案件进行了频率。该研究涉及对所有研究对象的两份问卷和血液和尿液的收集。如果前列腺切除术后可用，将从癌症患者那里获得新鲜冻结的肿瘤标本。该研究调查评估了烟草使用，用药，饮食，医学和性史，家族癌症史和社会经济状况。这项研究得到了马里兰州的资源承包商开发的流行病学基础设施的支持，该基础设施进行了肺癌病例对照研究。这项肺癌研究正在进行中，前列腺癌研究募集的对照是与肺癌研究的关节对照。因此，我们承包商招募的基于人群的男性对照组具有并发肺和前列腺癌研究的双重资格。为了在前列腺研究中实现病例和对照的年龄和种族匹配，我们将在肺癌研究中过度样本的男性对照。这项研究和正在进行的肺部研究由最近建立的网站（http://home.ccr.cancer.gov/gemes/index.html）描述。该网站还介绍了涉及数据共享的合作政策。研究协议和两个问卷可以通过以下网址访问：http：//www3.cancer.gov/intra/lhc/ambs/prostate_cancer_case_case_control_study_study_protocol.pdf http://www3.cancer.gov/intra/lhc/Ambs/Lung_Prostate_Case_Control_Questionnaire.pdf http://www3.cancer.gov/intra/lhc/Ambs/Prostate_Cancer_Supplementary Questionnaire.pdf Our study is aimed at identifying differences in risk factor exposure and非裔美国人和欧美男人之间的肿瘤生物学。我们还将检验以下假设：环境和遗传因素及其相互作用有助于非裔美国人和欧洲裔美国人现有的前列腺癌健康差异。分子工作将用于检查肿瘤生物学的种族/种族差异。目前，我们已经招募了816例（429名欧美人和387名非裔美国人）和767个基于人群的对照（466名欧美人和301名非裔美国人），并从这些人那里收集了血液和尿液。我们还收集了石蜡包裹的和新鲜的冻结组织样品，形成了127个前列腺切除术手术。未来的招聘率每年设定为50-100例和50-100例对照，直到招募500名非裔美国人和500例欧美案件和500名非裔美国人和500名欧洲裔美国人的控制。