Multidisciplinary Training in TMJ Disorders/Pain: Integrating Basic, Translation

颞下颌关节疾病/疼痛的多学科培训：整合基础、翻译

• 批准号: 8568459
• 负责人: JEREMY J MAO
• 金额: $ 29万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8568459
• 关键词: Area; Arthralgia; Biocompatible Materials; Biological Sciences; Biomechanics; Biomedical Engineering; Chemical Engineering; Clinical; Clinical Research; Collaborations; Connecticut; Consult; Dental; Dentistry; Dentists; Engineering; Faculty; Funding; Genetic; Goals; Grant; Image; Interdisciplinary Study; Learning; Medical; Medicine; Mentors; Mentorship; Molecular Genetics; National Institute of Dental and Craniofacial Research; Natural regeneration; New Jersey; New York; New York City; Orofacial Pain; Pain; Pain Clinics; Patients; Philadelphia; Physiology; Positioning Attribute; Public Health; Recruitment Activity; Research; Research Personnel; Resources; SECTM1 gene; Schools; Scientist; Stem cells; Students; Temporomandibular Joint; Temporomandibular Joint Disorders; Temporomandibular joint disorder pain; Training; Training Programs; Translational Research; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Work; career; career development; college; craniofacial; experience; member; multidisciplinary; novel; novel strategies; programs; response; social; stem; symposium

DESCRIPTION (provided by applicant): Columbia University is uniquely positioned to develop scientists and/or clinicians towards independent research careers in temporomandibular joint disorders and pain (TMJDP). Through strategic recruitment in the past ~5 years, Columbia University College of Dental Medicine (CDM) now has a critical mass of NIH funded, primary and secondary faculty members whose research is directly in TMJDP. In parallel, multiple clusters of key recruitments in medical and engineering schools have yielded cadres of leading scientists in molecular genetics, biomaterials, chemical engineering and bioengineering whose expertise, when integrated with TMJDP, generates powerful and novel approaches. Collectively, our faculty mentors have over 28 NIH R01s that offer both the breadth and depth to trainees that will be recruited on this grant. Prior to this FOA, the CDM has established a track record of career development of multiple junior faculty members, with one example of a dentist/scientist whose work in novel TMJ stem/progenitor cells has received NIDCR K99/R00 funding, in addition to recognition as 1st place Hatton Awardees separately at 2012 AADR and IADR Conferences. This TMJDP training program has built key partnerships and leveraged tremendous resources that are currently available at Columbia. Interdisciplinary research is a particular strength at Columbia, with existing collaborations among dentistry, medicine, engineering, biological science and public health. The long-standing TMJ/Orofacial Pain Clinic (est. 1949) treats a broad range of patients not only in New York City, but also surrounding areas of New York, New Jersey, Connecticut and Northern Philadelphia, offering a fertile platform for translational and clinical research. Columbia University in the City of New York attracts abundant candidates with diverse academic, clinical, social and ethnic background, including underrepresented minorities, by offering them a broad range of learning opportunities. The overall objective of this K12 proposal is to prepare and develop scientists and/or clinicians into independent research investigators in TMJDP. We will set up a sustainable pipeline of Recruitment, Mentorship and Career Transition (RMCT). We will take a trainee-centered approach, very much along the Columbia tradition to focus on each student by maximizing his/her own learning experience. In response to this FOA, our Internal Steering Committee has performed a SWOP analysis (Strengths, Weaknesses, Opportunities and Threats) and consulted members of our Internal and External Advisory Panels. Accordingly, we have set the following 3 training tracks: Genetics/Physiology, Bioengineering/Regeneration and Imaging/Biomechanics. Our long-term goal, above and beyond this 5-year grant, is to continue with a successful and sustainable program to develop independent research investigators in TMJDP and other areas of dental and craniofacial research.

描述(由申请者提供)：哥伦比亚大学在培养科学家和/或临床医生在颞下颌关节紊乱和疼痛(TMJDP)方面的独立研究事业方面具有独特的地位。通过过去5年的战略招聘，哥伦比亚大学牙科医学院(CDM)现在拥有一大批由NIH资助的初级和二级教员，他们的研究直接在TMJDP进行。与此同时，医学和工程学院的多个关键招聘集群已经培养出一批分子遗传学、生物材料、化学工程和生物工程领域的顶尖科学家，他们的专业知识与TMJDP相结合，产生了强大而新颖的方法。总体而言，我们的教师导师拥有超过28名NIH R01，为将在此笔拨款中招聘的学员提供广度和深度两方面的培训。在此之前，清洁发展机制已经建立了多名初级教员的职业发展记录，例如一名牙医/科学家在新型TMJ干细胞/祖细胞方面的工作获得了NIDCR K99/R00资助，此外还分别在2012年AADR和IADR会议上被评为哈顿奖第一名。这一TMJDP培训计划建立了关键的合作伙伴关系，并利用了哥伦比亚大学目前可用的大量资源。跨学科研究是哥伦比亚大学的一项特别优势，现有的合作领域包括牙科、医学、工程学、生物科学和公共卫生。成立已久的TMJ/口腔面部疼痛诊所(Est.1949年)不仅在纽约市，而且在纽约、新泽西、康涅狄格和费城北部的周边地区治疗广泛的患者，为翻译和临床研究提供了一个肥沃的平台。纽约市的哥伦比亚大学通过为他们提供广泛的学习机会，吸引了大量具有不同学术、临床、社会和种族背景的候选人，包括代表人数较少的少数族裔。这项K12提案的总体目标是将科学家和/或临床医生培养成TMJDP的独立研究调查员。我们将建立一个可持续的招聘、指导和职业过渡(RMCT)渠道。我们将采取以学员为中心的方法，非常沿袭哥伦比亚大学的传统，通过最大化每个学生的学习经验来关注他们。针对这一FOA，我们的内部指导委员会进行了SWOP分析(优势、劣势、机会和威胁)，并咨询了我们内部和外部咨询小组的成员。相应地，我们设置了遗传学/生理学、生物工程/再生和成像/生物力学三个培训轨道。除了这笔为期5年的拨款外，我们的长期目标是继续实施一项成功和可持续的计划，在TMJDP和其他牙科和颅面研究领域培养独立的研究人员。