Multidisciplinary Training in TMJ Disorders/Pain: Integrating Basic, Translation

颞下颌关节疾病/疼痛的多学科培训：整合基础、翻译

• 批准号: 8691782
• 负责人: JEREMY J MAO
• 金额: $ 29万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8691782
• 关键词: Area; Arthralgia; Biocompatible Materials; Biological Sciences; Biomechanics; Biomedical Engineering; Chemical Engineering; Clinical; Clinical Research; Collaborations; Connecticut; Consult; Dental; Dentistry; Dentists; Engineering; Faculty; Funding; Genetic; Goals; Grant; Image; Interdisciplinary Study; Learning; Medical; Medicine; Mentors; Mentorship; Molecular Genetics; National Institute of Dental and Craniofacial Research; Natural regeneration; New Jersey; New York; New York City; Orofacial Pain; Pain; Pain Clinics; Patients; Philadelphia; Physiology; Positioning Attribute; Public Health; Recruitment Activity; Research; Research Personnel; Resources; SECTM1 gene; Schools; Scientist; Stem cells; Students; Temporomandibular Joint; Temporomandibular Joint Disorders; Temporomandibular joint disorder pain; Training; Training Programs; Translational Research; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Work; career; career development; college; craniofacial; experience; member; multidisciplinary; novel; novel strategies; programs; response; social; stem; symposium

DESCRIPTION (provided by applicant): Columbia University is uniquely positioned to develop scientists and/or clinicians towards independent research careers in temporomandibular joint disorders and pain (TMJDP). Through strategic recruitment in the past ~5 years, Columbia University College of Dental Medicine (CDM) now has a critical mass of NIH funded, primary and secondary faculty members whose research is directly in TMJDP. In parallel, multiple clusters of key recruitments in medical and engineering schools have yielded cadres of leading scientists in molecular genetics, biomaterials, chemical engineering and bioengineering whose expertise, when integrated with TMJDP, generates powerful and novel approaches. Collectively, our faculty mentors have over 28 NIH R01s that offer both the breadth and depth to trainees that will be recruited on this grant. Prior to this FOA, the CDM has established a track record of career development of multiple junior faculty members, with one example of a dentist/scientist whose work in novel TMJ stem/progenitor cells has received NIDCR K99/R00 funding, in addition to recognition as 1st place Hatton Awardees separately at 2012 AADR and IADR Conferences. This TMJDP training program has built key partnerships and leveraged tremendous resources that are currently available at Columbia. Interdisciplinary research is a particular strength at Columbia, with existing collaborations among dentistry, medicine, engineering, biological science and public health. The long-standing TMJ/Orofacial Pain Clinic (est. 1949) treats a broad range of patients not only in New York City, but also surrounding areas of New York, New Jersey, Connecticut and Northern Philadelphia, offering a fertile platform for translational and clinical research. Columbia University in the City of New York attracts abundant candidates with diverse academic, clinical, social and ethnic background, including underrepresented minorities, by offering them a broad range of learning opportunities. The overall objective of this K12 proposal is to prepare and develop scientists and/or clinicians into independent research investigators in TMJDP. We will set up a sustainable pipeline of Recruitment, Mentorship and Career Transition (RMCT). We will take a trainee-centered approach, very much along the Columbia tradition to focus on each student by maximizing his/her own learning experience. In response to this FOA, our Internal Steering Committee has performed a SWOP analysis (Strengths, Weaknesses, Opportunities and Threats) and consulted members of our Internal and External Advisory Panels. Accordingly, we have set the following 3 training tracks: Genetics/Physiology, Bioengineering/Regeneration and Imaging/Biomechanics. Our long-term goal, above and beyond this 5-year grant, is to continue with a successful and sustainable program to develop independent research investigators in TMJDP and other areas of dental and craniofacial research.

描述（由申请人提供）：哥伦比亚大学具有独特的优势，可以培养科学家和/或临床医生从事颞下颌关节疾病和疼痛 (TMJDP) 的独立研究职业。通过过去约 5 年的战略招聘，哥伦比亚大学牙科医学院 (CDM) 现在拥有大量由 NIH 资助的小学和中学教职人员，他们的研究直接在 TMJDP 中进行。与此同时，医学和工程学校的多个关键招聘集群培养了分子遗传学、生物材料、化学工程和生物工程领域领先科学家的骨干队伍，他们的专业知识与 TMJDP 相结合，产生了强大而新颖的方法。总的来说，我们的教师导师拥有超过 28 名 NIH R01，为将通过这笔资助招募的学员提供了广度和深度的培训。在此 FOA 之前，CDM 已建立了多名初级教员的职业发展记录，其中一位牙医/科学家在新型 TMJ 干/祖细胞方面的工作获得了 NIDCR K99/R00 资助，此外还分别在 2012 年 AADR 和 IADR 会议上被认可为第一名哈顿奖获得者。该 TMJDP 培训计划建立了重要的合作伙伴关系，并利用了哥伦比亚目前可用的大量资源。跨学科研究是哥伦比亚大学的独特优势，牙科、医学、工程、生物科学和公共卫生之间现有合作。历史悠久的颞下颌关节/口面部疼痛诊所（成立于 1949 年）不仅为纽约市以及纽约周边地区、新泽西州、康涅狄格州和费城北部地区的广大患者提供治疗，为转化和临床研究提供了丰富的平台。纽约市的哥伦比亚大学通过为他们提供广泛的学习机会，吸引了大量具有不同学术、临床、社会和种族背景的候选人，包括代表性不足的少数族裔。 K12 提案的总体目标是培养科学家和/或临床医生成为 TMJDP 的独立研究人员。我们将建立可持续的招聘、指导和职业转型（RMCT）渠道。我们将采取以学员为中心的方法，非常遵循哥伦比亚大学的传统，通过最大化他/她自己的学习经验来关注每个学生。为了响应此 FOA，我们的内部指导委员会进行了 SWOP 分析（优势、劣势、机遇和威胁），并咨询了我们的内部和外部咨询小组成员。据此，我们设置了以下3个培训方向：遗传学/生理学、生物工程/再生和成像/生物力学。除了这项为期 5 年的资助之外，我们的长期目标是继续实施成功且可持续的计划，以培养 TMJDP 以及牙科和颅面研究其他领域的独立研究人员。