International Conference on Dental and Craniofacial Stem Cells

描述（由申请人提供）：在过去的二十年中，具有干细胞/祖细胞特性的细胞已经从牙科，口腔和颅面（DOC）组织中分离和鉴定出来。在牙科和颅面研究的历史上，第一次有可能操纵分化成面部和口腔中许多组织的细胞。牙科和颅面重建的实践依赖于DOC干细胞/祖细胞衍生的组织，并将随着时间的推移，通过基于对DOC干细胞/祖细胞的理解的翻译和治疗方法的发展而转变。然而，我们对DOC干细胞/祖细胞的现有知识充其量是零碎的。DOC干细胞来源于神经嵴来源的间充质，具有独特的特征，将它们与通常研究的骨髓来源的间充质细胞区分开来。自大约9年前发现DOC干细胞/祖细胞以来，有关其的科学文献数量呈指数增长。令人担忧的是，DOC干细胞/祖细胞正在被注入临床前模型，而患者对其行为只有零散的了解。因此，我们提议召开第一次牙科、口腔和颅面干细胞/祖细胞国际会议，不仅讨论和传播有关DOC干/祖细胞生物学的最新知识，而且讨论它们在口腔和面部组织再生中的应用。本提案的总体目标是设计和规划第一届牙科和颅面干细胞国际会议（ICDCSC），在一个论坛上促进知识的传播和确定与DOC干细胞/祖细胞研究和翻译相关的未来方向。与会者之间的广泛共识将形成建立科学指南的基础，包括对DOC干细胞/祖细胞的自我更新、分化和翻译进行严格的分子和功能分析。本次会议计划于2010年10月在纽约市举行，这里有许多美国和国际城市的直飞航班，会议环境有利于多学科讨论DOC干细胞/祖细胞的科学和治疗潜力。来自牙科、生物技术和制药行业的科学家、临床医生、政府官员和行业代表将广泛参加会议。我们得到了来自科学家，政府官员，牙科，生物技术和制药行业的强烈回应。本次会议的结果将发表在高影响力的干细胞或再生医学杂志上，并作为动态生物学和DOC干细胞/祖细胞翻译领域的工作和发展指南。

DESCRIPTION (provided by applicant): In the past two decades, cells with properties of stem/progenitor cells have been isolated and identified from dental, oral and craniofacial (DOC) tissues. For the first time in the history of dental and craniofacial research, it is possible to manipulate the very cells that differentiate into many of the tissues in the face and oral cavity. The practice of dentistry and craniofacial reconstruction rests on tissues that derived from DOC stem/progenitor cells, and will be transformed, over time, by the development of translational and therapeutic approaches based on the understanding of DOC stem/progenitor cells. However, our existing knowledge of DOC stem/progenitor cells is fragmentary at best. DOC stem cells originate from neural crest-derived mesenchyme, and possess unique characteristics that distinguish them from commonly studied bone-marrow derived mesenchymal cells. Upon their discovery about 9 years ago, the volume of scientific literature on DOC stem/progenitor cells has grown exponentially. Alarmingly, DOC stem/progenitor cells are being infused in preclinical models and patients with only fragmented knowledge of their behavior. Accordingly, we propose the first international conference dedicated to dental, oral and craniofacial stem/progenitor cells, not only to discuss and disseminate current knowledge on the biology of DOC stem/progenitor cells, but also their putative applications in the regeneration of tissues of the oral cavity and the face. The overall goal of this proposal is to design and plan the first International Conference on Dental and Craniofacial Stem Cells (ICDCSC) in a forum that promotes the dissemination of knowledge and identification of future directions in relation to DOC stem/progenitor cell research and translation. Broad consensus among conference participants will form the basis for establishing scientific guidelines, including rigorous molecular and functional assays for self renewal, differentiation and translation of DOC stem/progenitor cells. This conference is being planned to take place in October, 2010 in New York City, which has direct flights to/from numerous U.S. and international cities, and in a setting that is conducive for multi-disciplinary discussion of the science and therapeutic potential of DOC stem/progenitor cells. The conference will be widely attended by scientists, clinicians, government officials, and industry representatives in dental, biotechnology and pharmaceutical industries. We have received overwhelmingly robust response from not only scientists, but also government officials and dental, biotechnology and pharmaceutical industry. The outcome of this conference will be published in a high impact stem cell or regenerative medicine journal and serve as working and evolving guidelines for the dynamic field of the biology and translation of DOC stem/progenitor cells. PUBLIC HEALTH RELEVANCE: In the past decade and beyond, postnatal cells with properties of stem/progenitor cells have been isolated and identified from dental, oral and craniofacial (DOC) tissues. For the first time in the history of dental and craniofacial research, we have the ability to manipulate the very cells that differentiate into many tissue or organ in the face and oral cavity. It is projected that the practice of dentistry and craniofacial reconstruction will be transformed, over time, by the development of translational and therapeutic approaches that rely on the understanding of DOC stem cells. The overall goal of this proposal is to design and plan the first International Conference on Dental and Craniofacial Stem Cells (ICDCSC) in a forum that promotes the dissemination of knowledge and identification of future directions in relation to DOC stem/progenitor cell research and translation. The conference will be widely attended by scientists, clinicians, government officials, and industry representatives in dental, biotechnology and pharmaceutical industries. The outcome of this conference will be published in a high impact stem cell or regenerative medicine journal and serve as working and evolving guidelines for the dynamic field of the biology and translation of DOC stem/progenitor cells.