University of New Mexico Interdisciplinary HPV Prevention Center

每年报告的性传播人类乳头瘤病毒(HPV)感染新病例超过600万例，使HPV成为世界上最常见的性传播病原体。然而，至少有15种致癌HPV类型会导致几乎所有的宫颈癌；2006年获得许可的昂贵的HPV疫苗仅覆盖HPV6/11/16/18型，对已确定的感染没有治疗作用。因此，所有妇女必须继续进行常规的宫颈筛查，美国每年的费用为40-50亿美元。更重要的是，今天在世的大多数女性仍有患宫颈癌的风险。此外，目前的疫苗计划使所有男性都得不到保护。鉴于这些考虑，以及宫颈癌是一种差异疾病的事实，目前的战略不太可能实现预期的疾病减少。目前美国HPV疫苗的实施和有效性仍需要一些项目，继续努力更好地了解HPV生物学并为现有感染制定广泛的保护性预防策略和治疗方法仍然至关重要。这项申请的具体目标是：1)建立新墨西哥大学跨学科HPV预防中心，该中心采用研究方法来解决这些知识差距。2)资助和支持代表一系列跨学科方法的4个项目，包括：a)在3个维度对光伏-宿主相互作用进行建模，以确定有助于感染发病机制和预防的上皮细胞生物学和免疫要素；b)利用基于病毒显示技术的新型疫苗策略，产生针对大多数HPV感染的广泛保护；c)利用独特的生物信息学系统，该系统捕获美国基于人口的宫颈筛查计划的所有事件，以表征主要和次要HPV干预措施的实施情况和有效性；以及d)开发一套基于网络的工具，以促进知情地采用HPV和其他性传播感染预防措施。3)建立2个共享资源的核心，以支持这些跨学科研究方法：A)生物统计学和生物信息学核心，B)病毒感染核心，支持病毒生产、定量和动物成像技术，并容纳生物标本资源。

Over 6 million new cases of sexually transmitted human papillomavirus (HPVs) infections are reported every year making HPV the most common sexually transmitted agent world-wide. At least 15 carcinogenic HPV types cause virtually all cervical cancers however; the costly HPV vaccine licensed in 2006 covers only HPV types 6/11/16/18 and has no therapeutic effect on established infections. Thus all women must continue routine cervical screening at a US cost of $4-5 billion annually. More importantly, the majority of women alive today are still at risk for developing cervical cancer. In addition, the current vaccine program presently leaves all men unprotected. Given these considerations and the fact that cervical cancer is a disease of disparities, it is unlikely that projected disease reductions will be realized with current strategies. Programs to characterize current US HPV vaccine implementation and effectiveness are needed and continuing efforts to better understand HPV biology and to develop broadly protective prevention strategies and therapeutics for existing infections remain critical. The specific aims of this application are: 1) To establish the University of New Mexico Interdisciplinary HPV Prevention Center that incorporates research approaches to address these gaps in knowledge. 2) To fund and support 4 projects representing a spectrum of interdisciplinary approaches including: A) modeling of PV-host interactions in 3 dimensions to define elements of epithelial cell biology and immunity that contribute to the pathogenesis and prevention of infections; B) utilizing novel vaccine strategies based on virus-display technology to generate broad protection against a majority of HPV infections; C) utilizing a unique bioinformatics system that captures all events of a US population-based cervical screening program to characterize implementation and effectiveness of primary and secondary HPV interventions; and D) developing a set of web-based tools to promote the informed adoption of HPV and other STI prevention. 3) To establish 2 cores housing shared resources to support these interdisciplinary research approaches: A) a biostatistics and bioinformatics core and B) a virus infection core supporting technologies for virus production, quantitation, and animal imaging and housing a biospecimen resource.