University of New Mexico Interdisciplinary HPV Prevention Center

每年有超过600万例新的性传播人乳头瘤病毒（HPV）感染病例报告，使HPV成为世界范围内最常见的性传播媒介。然而，至少有15种致癌的HPV类型导致几乎所有的宫颈癌; 2006年批准的昂贵的HPV疫苗仅涵盖HPV 6/11/16/18型，对已建立的感染没有治疗效果。因此，所有妇女都必须继续进行常规宫颈筛查，美国每年的费用为40亿至50亿美元。更重要的是，今天活着的大多数妇女仍然有患宫颈癌的风险。此外，目前的疫苗计划使所有男子都得不到保护。考虑到这些因素以及宫颈癌是一种差异性疾病的事实，目前的战略不太可能实现预计的疾病减少。目前美国HPV疫苗的实施和有效性的特点的计划是必要的，继续努力，以更好地了解HPV生物学和开发广泛的保护性预防策略和治疗现有的感染仍然至关重要。本申请的具体目的是：1）建立新墨西哥州大学跨学科HPV预防中心，该中心采用研究方法来解决这些知识差距。2)资助和支持4个代表一系列跨学科方法的项目，包括：A）在3个维度上建立HPV-宿主相互作用的模型，以确定有助于感染发病和预防的上皮细胞生物学和免疫力的要素; B）利用基于病毒展示技术的新型疫苗策略，对大多数HPV感染产生广泛的保护作用; C）利用独特的生物信息学系统，捕获美国基于人群的宫颈筛查计划的所有事件，以表征初级和二级HPV干预措施的实施和有效性;以及D）开发一套基于网络的工具，以促进HPV和其他STI预防的知情采用。3)建立2个核心，容纳共享资源，以支持这些跨学科研究方法：A）生物统计学和生物信息学核心和B）病毒感染核心，支持病毒生产、定量和动物成像技术，并容纳生物标本资源。

Over 6 million new cases of sexually transmitted human papillomavirus (HPVs) infections are reported every year making HPV the most common sexually transmitted agent world-wide. At least 15 carcinogenic HPV types cause virtually all cervical cancers however; the costly HPV vaccine licensed in 2006 covers only HPV types 6/11/16/18 and has no therapeutic effect on established infections. Thus all women must continue routine cervical screening at a US cost of $4-5 billion annually. More importantly, the majority of women alive today are still at risk for developing cervical cancer. In addition, the current vaccine program presently leaves all men unprotected. Given these considerations and the fact that cervical cancer is a disease of disparities, it is unlikely that projected disease reductions will be realized with current strategies. Programs to characterize current US HPV vaccine implementation and effectiveness are needed and continuing efforts to better understand HPV biology and to develop broadly protective prevention strategies and therapeutics for existing infections remain critical. The specific aims of this application are: 1) To establish the University of New Mexico Interdisciplinary HPV Prevention Center that incorporates research approaches to address these gaps in knowledge. 2) To fund and support 4 projects representing a spectrum of interdisciplinary approaches including: A) modeling of PV-host interactions in 3 dimensions to define elements of epithelial cell biology and immunity that contribute to the pathogenesis and prevention of infections; B) utilizing novel vaccine strategies based on virus-display technology to generate broad protection against a majority of HPV infections; C) utilizing a unique bioinformatics system that captures all events of a US population-based cervical screening program to characterize implementation and effectiveness of primary and secondary HPV interventions; and D) developing a set of web-based tools to promote the informed adoption of HPV and other STI prevention. 3) To establish 2 cores housing shared resources to support these interdisciplinary research approaches: A) a biostatistics and bioinformatics core and B) a virus infection core supporting technologies for virus production, quantitation, and animal imaging and housing a biospecimen resource.