Epidemiology and Prevention Interdisciplinary Center for Sexually Transmitted Inf

性传播感染疾病流行病学与预防跨学科中心

• 批准号: 8769910
• 负责人: Cosette Marie Wheeler
• 金额: $ 254.55万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8769910
• 关键词: Address; Adopted; Animal Model; Anogenital venereal warts; Antigens; Basic Science; Bioinformatics; Biometry; CD4 Positive T Lymphocytes; Cellular Immunity; Centers for Disease Control and Prevention (U.S.); Cervical; Cervical Cancer Screening; Cervical Intraepithelial Neoplasia; Chlamydia trachomatis; Clinical; Collaborations; Combined Vaccines; Communication; Data Set; Development; Discipline; Disease Outcome; Ectopic Pregnancy; Effectiveness; Ensure; Epidemiologic Studies; Epidemiology; Evaluation; Funding; Generations; Genital system; Genotype; Goals; Guidelines; HPV-High Risk; Health; Health Care Costs; Human Papilloma Virus Vaccination; Human Papillomavirus; Human papillomavirus 6; Immune response; Immunity; Immunology; Individual; Infection; Infection prevention; Infertility; Informatics; Information Systems; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Lesion; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measures; Mentors; Mentorship; Molecular; Morbidity - disease rate; Mucosal Immunity; Mucous Membrane; Mus; National Institute of Allergy and Infectious Disease; Natural History; New Mexico; Outcome; Pelvic Inflammatory Disease; Population; Positioning Attribute; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Prevention; Prevention approach; Public Health; Public Health Informatics; Public Health Practice; Refractory; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Sexually Transmitted Diseases; System; Technology; Translations; United States; Universities; Vaccines; Virus; Woman; adverse outcome; aged; base; burden of illness; career; child bearing; cohort; density; design; disorder prevention; epidemiologic data; evidence base; genital infection; in vitro Model; international center; knowledge base; mortality; new technology; novel; novel strategies; novel vaccines; novel virus; outreach; population based; programs; prospective; psychosocial; reproductive; response; screening; success; technology development; trafficking; vaccine development

DESCRIPTION (provided by applicant): Despite the availability of public health interventions for their prevention and control, in 2011 the CDC estimated 14.1 million new cases of human papillomavirus (HPV) and 2.86 million new cases of Chlamydia trachomatis (CT) infection in the US. While both infections are asymptomatic in most women, they can have serious health consequences including cancer, pre-term pregnancy outcomes, pelvic inflammatory disease, ectopic pregnancy and infertility. The greatest promise for progress in reducing the burden of HPV and CT will result from integration of evaluation of current prevention and control measures with basic research designed to understand limitations to current strategies and adapt new technologies and information for continuous evidence-based improvement in outcomes. The specific aims of this Sexually Transmitted Infection Cooperative Research Center (STI-CRC) application are to (1) expand the scope of the current University of New Mexico (UNM) STI-CRC by establishing the Epidemiology and Prevention Interdisciplinary Center for Sexually Transmitted Infections (EPIC-STI), a center with a focus on HPV and CT infections that incorporates cooperative multidisciplinary research approaches to address key gaps in the knowledge required to reduce the burden of preventable or treatable sexually transmitted infections, (2) fund and support 4 integrated and inter-disciplinary projects that (a) elucidate th details of the development of CD4+ T-cell protective immunity against CT infection of the genital tract, (b) utilize novel virus-display technology to develop vaccine strategies for the durable and effective prevention of HPV and CT infection, (c) use mixed design approaches to characterize the burden of sexually transmitted infection and co-infection in the population as well as the within- and between woman variability of host response to CT infection, and (d) employ unique health informatics systems to delineate the effectiveness of HPV vaccination and evolving cervical cancer screening practices on the burden of STIs and their associated disease outcomes using population-based approaches; 3) Establish two cores that support the EPIC-STI trans-disciplinary research approaches and; 4) contribute to building the next cadre of STI researchers through mentorship and developmental research projects.

描述（由申请人提供）：尽管可以采取公共卫生干预措施进行预防和控制，但 2011 年 CDC 估计美国新增 1,410 万例人乳头瘤病毒 (HPV) 病例和 286 万例沙眼衣原体 (CT) 感染新病例。虽然这两种感染对大多数女性来说都是无症状的，但它们可能会产生严重的健康后果，包括癌症、早产、盆腔炎、宫外孕和不孕症。在减少 HPV 和 CT 负担方面取得进展的最大希望将来自对当前预防和控制措施的评估与旨在了解当前策略的局限性并采用新技术和信息以持续改善结果的基础研究的结合。该性传播感染合作研究中心 (STI-CRC) 申请的具体目标是 (1) 通过建立性传播感染流行病学和预防跨学科中心 (EPIC-STI) 来扩大当前新墨西哥大学 (UNM) STI-CRC 的范围，该中心专注于 HPV 和 CT 感染，结合合作多学科研究方法来解决关键差距 减少可预防或可治疗的性传播感染负担所需的知识，(2) 资助和支持 4 个综合性跨学科项目，这些项目 (a) 阐明针对生殖道 CT 感染的 CD4+ T 细胞保护性免疫的发展细节，(b) 利用新型病毒展示技术制定持久和有效的疫苗策略 有效预防 HPV 和 CT 感染，(c) 使用混合设计方法来描述人群中性传播感染和合并感染的负担，以及女性内部和女性之间对 CT 感染的宿主反应的变异性，以及 (d) 采用独特的健康信息学系统来描述 HPV 疫苗接种和不断发展的宫颈癌筛查实践对 STI 负担及其相关疾病结果的有效性。 方法； 3) 建立两个支持 EPIC-STI 跨学科研究方法的核心； 4) 通过指导和发展研究项目，为培养下一代 STI 研究人员骨干做出贡献。