Epidemiology and Prevention Interdisciplinary Center for Sexually Transmitted Inf

描述(由申请人提供)：尽管有公共卫生干预措施可用于预防和控制，但美国疾病控制与预防中心估计，2011年美国新增人乳头状瘤病毒(HPV)感染病例1410万例，沙眼衣原体(CT)感染新病例286万例。虽然这两种感染在大多数女性中都没有症状，但它们可能会造成严重的健康后果，包括癌症、早孕结局、盆腔炎、宫外孕和不孕。在减少HPV和CT负担方面取得进展的最大希望将是将对当前预防和控制措施的评估与基础研究相结合，这些研究旨在了解当前战略的局限性，并采用新技术和信息，以持续改善结果。性传播感染合作研究中心(STI-CRC)申请的具体目标是(1)通过建立性传播感染流行病学和预防跨学科中心(EPIC-STI)来扩大目前新墨西哥大学(UNM)STI-CRC的范围，这是一个以HPV和CT感染为重点的中心，采用了合作的多学科研究方法，以解决减少可预防或可治疗的性传播感染负担所需知识的关键空白，(2)资助和支持4个综合和跨学科项目，这些项目(A)阐明针对生殖道CT感染的CD4+T细胞保护性免疫的发展细节，(B)利用新的病毒展示技术为耐用和 为有效预防人乳头瘤病毒和沙眼衣原体感染，(C)采用混合设计办法，以确定人口中性传播感染和合并感染的负担，以及妇女内部和妇女之间对沙眼衣原体感染反应的可变性；(D)利用独特的保健信息学系统，说明人乳头瘤疫苗接种和不断发展的宫颈癌筛查做法对性传播感染负担及其相关疾病结果的有效性；3)建立两个支持EPIC-STI跨学科研究方法的核心；4)通过辅导和发展研究项目，促进培养下一批性传播感染研究人员。

DESCRIPTION (provided by applicant): Despite the availability of public health interventions for their prevention and control, in 2011 the CDC estimated 14.1 million new cases of human papillomavirus (HPV) and 2.86 million new cases of Chlamydia trachomatis (CT) infection in the US. While both infections are asymptomatic in most women, they can have serious health consequences including cancer, pre-term pregnancy outcomes, pelvic inflammatory disease, ectopic pregnancy and infertility. The greatest promise for progress in reducing the burden of HPV and CT will result from integration of evaluation of current prevention and control measures with basic research designed to understand limitations to current strategies and adapt new technologies and information for continuous evidence-based improvement in outcomes. The specific aims of this Sexually Transmitted Infection Cooperative Research Center (STI-CRC) application are to (1) expand the scope of the current University of New Mexico (UNM) STI-CRC by establishing the Epidemiology and Prevention Interdisciplinary Center for Sexually Transmitted Infections (EPIC-STI), a center with a focus on HPV and CT infections that incorporates cooperative multidisciplinary research approaches to address key gaps in the knowledge required to reduce the burden of preventable or treatable sexually transmitted infections, (2) fund and support 4 integrated and inter-disciplinary projects that (a) elucidate th details of the development of CD4+ T-cell protective immunity against CT infection of the genital tract, (b) utilize novel virus-display technology to develop vaccine strategies for the durable and effective prevention of HPV and CT infection, (c) use mixed design approaches to characterize the burden of sexually transmitted infection and co-infection in the population as well as the within- and between woman variability of host response to CT infection, and (d) employ unique health informatics systems to delineate the effectiveness of HPV vaccination and evolving cervical cancer screening practices on the burden of STIs and their associated disease outcomes using population-based approaches; 3) Establish two cores that support the EPIC-STI trans-disciplinary research approaches and; 4) contribute to building the next cadre of STI researchers through mentorship and developmental research projects.