Archiving Datasets of the Brain & Aging Research Program

归档大脑数据集

• 批准号: 8370496
• 负责人: Perminder S SACHDEV
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF NEW SOUTH WALES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8370496
• 关键词: Age; Age-Years; Aging; Archives; Australia; Behavioral; Biochemical Genetics; Biological; Blood Chemical Analysis; Brain Diseases; Centenarian; Cognitive; Cohort Studies; Commit; Communities; Data; Data Set; Data Sources; Databases; Dementia; Disease; Dizygotic Twins; Documentation; Elderly; Environmental Risk Factor; Genetic; Genomics; Human; Impaired cognition; Individual; International; Investigation; Longevity; Medical; Medical History; Medical Imaging; Memory; Monozygotic Twinning; Monozygotic twins; Morbidity - disease rate; Neurocognitive; New South Wales; Participant; Patients; Pharmaceutical Preparations; Phenotype; Proteomics; Psychiatry; Psychosocial Assessment and Care; Public Domains; Questionnaires; Relative (related person); Research; Research Personnel; Resources; Risk; Schools; Stroke; Survivors; Twin Multiple Birth; Twin Studies; Universities; age related; aged; aging brain; base; cohort; healthy aging; longitudinal database; mild neurocognitive impairment; neuroimaging; neuropsychiatry; neuropsychological; novel; programs; psychologic; social; suburb; theories

DESCRIPTION (provided by applicant): The acquisition of comprehensive datasets containing phenotypic, biological, psychological and social information is expensive and labor-intensive but is necessary for the investigation of aging and related disorders. The Brain and Ageing Research Program ('BARP', University of New South Wales, Australia) has committed substantial resources over the last decade to establish cohorts and collect rich multi-faceted longitudinal datasets on older individuals in Australia. The cohorts include community-dwelling non-demented individuals, twin pairs, centenarians/ near-centenarians and stroke survivors, and the data ranging from biochemical, genetic & medical imaging data through to detailed neuropsychological, behavioral and demographic information collected longitudinally over multiple waves. The current project proposes to re-format these extensive databases for release into the public domain so that the data can be shared openly and analyzed by researchers around the world. This will contribute to the international effort to investigate aging and age-related brain diseases. The BARP databases comprise 4 longitudinal cohort studies: 1. The Memory & Ageing Study (MAS): a study of 1000+ community-based non-demented individuals from the Eastern suburbs of Sydney (Australia) which began in 2005 and collects information from its participants on an annual basis, with detailed assessments every two years, including neuroimaging, genetics and proteomics. Its primary aim is to determine the risk and protective factors in relation to cognitive decline in aging and dementia (n = 1000+; 2000+ variables per assessment). 2. The Older Australian Twins Study (OATS): a study of 300+ Australian monozygotic and dizygotic twin pairs which began in 2007 and collects information on an annual basis. It aims to determine the relative impact of genetics vs. environmental factors in relation to both cognitive decline and healthy aging (n = 600; 2000+ variables per assessment). 3. The Sydney Centenarian Study (SCS): a study of individuals aged 95+ years of age which began in 2008 and collects information from its participants on a 6 monthly basis (max. 3 assessments). It aims to compare cognitive decline and healthy aging in relation to exceptional longevity, as well as investigating the so-called 'super healthy' human phenotype described by compression-of-morbidity theories (n = 250+; 1000+ variables per assessment). 4. The Sydney Stroke Study (SSS): a study of stroke patients and healthy controls assessed 3-6 months after the stroke then 1, 3 and 5 years later (n = 200 stroke; 100 controls; 1000+ variables per assessment). All 4 studies collected data on cognitive phenotypes (e.g. dementia/MCI+subtypes/healthy), neurocognitive assessment, psychosocial questionnaires, medical history + exam, medication use, neuroimaging, blood chemistry, proteomics and genetics/genomics (no proteomics or genetics for SSS). All studies collect data longitudinally and thus the BARP databases represent a truly rich and valuable potential data source for researchers worldwide. PUBLIC HEALTH RELEVANCE: The investigation of aging and age-related neuropsychiatric disorders is dependent upon the availability of well-characterized cohorts of aging individuals who have been assessed longitudinally. The Brain and Ageing Research Program at the University of New South Wales has established a number of longitudinal cohorts with extensive documentation. This proposal will see the public release of four longitudinal databases containing data (up to 2000+ variables per dataset) on over 2000 elderly individuals ranging from the healthy to those with dementia, and inclusive of four cohorts: community dwelling elderly (aged 70-90 years), elderly twins (aged >65 years), centenarians/ near-centenarians and stroke sufferers. The data include neuropsychiatric and medical assessments, neuroimaging, genetics and proteomics, and these cohorts will therefore provide a unique international resource for the investigation of ageing and associated disorders by researchers world-wide.

描述（由申请人提供）：获取包含表型、生物学、心理学和社会信息的综合数据集是昂贵且劳动密集型的，但对于衰老和相关疾病的调查是必要的。大脑和老龄化研究计划（'BARP'，澳大利亚新南威尔士大学）在过去十年中投入了大量资源，以建立队列，并收集澳大利亚老年人丰富的多方面纵向数据集。队列包括社区居住的非痴呆个体，双胞胎，百岁老人/近百岁老人和中风幸存者，以及从生物化学，遗传和医学成像数据到详细的神经心理学，行为和人口统计学信息的数据。目前的项目建议重新格式化这些广泛的数据库，以便向公共领域发布，以便世界各地的研究人员可以公开共享和分析数据。这将有助于国际上对衰老和与年龄有关的脑部疾病的研究。BARP数据库包括4项纵向队列研究：1.记忆与衰老研究（MAS）：一项对来自悉尼东郊（澳大利亚）的1000多名社区非痴呆症患者的研究，该研究始于2005年，每年收集参与者的信息，每两年进行一次详细评估，包括神经成像，遗传学和蛋白质组学。其主要目的是确定与衰老和痴呆中认知能力下降相关的风险和保护因素（n = 1000+;每次评估2000+变量）。2.澳大利亚老年双胞胎研究（OATS）：一项对300多对澳大利亚同卵和异卵双胞胎的研究，始于2007年，每年收集信息。它旨在确定遗传与环境因素对认知衰退和健康老龄化的相对影响（n = 600;每次评估2000+变量）。3.悉尼百岁老人研究（SCS）：一项针对95岁以上老人的研究，始于2008年，每6个月收集一次参与者的信息。3评价）。它的目的是比较认知能力下降和健康老龄化与异常长寿的关系，以及调查由发病率压缩理论描述的所谓的“超级健康”人类表型（n = 250+;每次评估1000+变量）。4.悉尼卒中研究（SSS）：一项卒中患者和健康对照的研究，在卒中后3-6个月，然后在1年、3年和5年后进行评估（n = 200例卒中; 100例对照;每次评估1000+变量）。所有4项研究均收集了关于认知表型（例如痴呆/MCI+亚型/健康）、神经认知评估、心理社会问卷、病史+检查、药物使用、神经影像学、血液化学、蛋白质组学和遗传学/基因组学（SSS无蛋白质组学或遗传学）的数据。所有研究都纵向收集数据，因此BARP数据库为全世界的研究人员提供了真正丰富和有价值的潜在数据源。 公共卫生关系：对衰老和与年龄相关的神经精神障碍的研究依赖于对衰老个体进行纵向评估的特征良好的队列的可用性。新南威尔士大学的大脑和老龄化研究计划建立了一些纵向队列，并提供了大量文件。该提案将公开发布四个纵向数据库，其中包含2000多名老年人的数据（每个数据集多达2000多个变量），从健康到痴呆症，包括四个队列：社区居住老年人（70-90岁），老年双胞胎（年龄>65岁），百岁老人/近百岁老人和中风患者。这些数据包括神经精神病学和医学评估、神经影像学、遗传学和蛋白质组学，因此，这些队列将为全世界研究人员调查老龄化和相关疾病提供独特的国际资源。