Administrative Core

项目总结(见说明)： 行政核心将由Kirkland博士(主任)、van Deursen博士和Campisi博士(联合主任)领导，以及一个由子项目和核心领导人组成的顾问小组。柯克兰博士是科戈德衰老中心的主任，范·德尔森博士是科戈德中心细胞衰老项目的主任，坎皮西博士是巴克研究所的主要研究员。由以下人士组成的外部谘询委员会(选管会) 在NIA工作人员的指导下，将组建具有衰老生物学、细胞衰老、脆弱性和/或衰老翻译研究专业知识的科学家。行政核心的任务是确保方案项目、其4个子项目、其基于器官系统的主题以及测试中的两个研究核心的成功 一种假说，认为防止衰老细胞的积累或其影响可以恢复与年龄有关的功能衰退。具体目标是：1)为PPG提供有效、高效的集中管理。2)协助将研究站点、子项目和研究核心整合到一个连贯的计划中。3)与东非共同体合作，定期评价项目小组、个别研究分项目和研究核心的进展情况。4)在梅奥诊所和巴克研究所组织以老龄化为重点的研讨会和会议。5)扩大现有的专注于细胞衰老和与年龄相关的功能衰退的合作者网络，特别是促进将结果转化为临床试验。核心将负责日常和长期的财务管理，定期维护 与NIA工作人员联系，准备年度进度报告/续签申请。它将与选管会合作，规划PPG的未来及其竞争对手的续签。我们组建了一个广泛合作的团队，目前正在联合研究细胞衰老在功能、脆弱、衰老和健康寿命中的作用。这种合作的历史导致了这一PPG。核心A将每2个月组织一次视频会议 为PPG参与者提供数周的时间，以审查子项目、核心业务的进展，并形成行动计划，以解决可能出现的新方向或困难。在过去的几年里，在准备这项提案的过程中，这一点取得了成功。核心A将为PPG参与者和选管会组织年度会议，以审查次级项目和核心，以及会议和研讨会，将PPG成员与其他成员聚集在一起，并促进新的合作。科戈德中心与巴克研究所有正式联系，包括互访教员和咨询委员会成员。该中心提供试点项目支持、博士后职位和梅奥与巴克研究所之间的旅行费用，为这一应用开发动物模型和初步数据。核心A将受益于它与科戈德中心和巴克研究所的关系。

PROJECT SUMMARY (See instructions): The Administrative Core will be led by Drs. Kirkland (Director), van Deursen, and Campisi (Co-Directors), and an advisory group of the Subproject and Core leaders. Dr. Kirkland is Director of the Kogod Center on Aging, Dr. van Deursen is Director of the Cellular Senescence Program of the Kogod Center, and Dr Campisi is a leading researcher at the Buck Institute. An External Advisory Committee (EAC) composed of scientists with expertise in aging biology, cellular senescence, frailty, and/or translational research on aging will be formed with guidance from NIA Staff. The Administrative Core's mission is to ensure success of the Program Project, its 4 Subprojects, its organ system-based Themes, and the two research Cores in testing the hypothesis that preventing the accumulation of senescent cells or their effects can restore age related decrements in function. Specific Aims are to: 1) Provide effective, efficient centralized administration for the PPG. 2) Assist in integrating the research sites, Subprojects, and research Cores into a cohesive program. 3) Evaluate the progress of the PPG, individual research Subprojects, and research Cores on a regular basis in partnership with the EAC. 4) Organize symposia and meetings focused on aging at Mayo Clinic and the Buck Institute. 5) Expand the existing network of collaborators focused on cellular senescence and age-related functional decline, especially to facilitate translation of outcomes into clinical trials. The Core will be responsible for day-to-day and long term fiscal management, maintain regular contact with NIA staff, and prepare annual progress reports/renewal applications. It will partner with the EAC to plan the future of the PPG and its competing renewal. We assembled a team that collaborates extensively and is currently jointly investigating the role of cellular senescence in function, frailty, aging, and healthspan. This history of collaboration led to this PPG. Core A will organize videoconferences every 2 weeks for PPG participants to review progress of the Subprojects, Core operation, and form action plans to address new directions or difficulties that may arise. This has been successful over the past couple of years while preparing this proposal. Core A will organize an annual meeting for PPG participants and the EAC to review Subprojects and Cores as well as meetings and seminars to bring PPG members together with others and foster new collaborations. The Kogod Center has formal links with the Buck Institute, including reciprocal faculty visits and Advisory Board membership. The Center provided pilot project support, postdoctoral positions, and travel costs between Mayo and the Buck Institute to develop the animal models and preliminary data for this application. Core A will benefit from its ties to the Kogod Center and Buck Institute.