The Next Step in Aging Research: From Bench to Bedside

描述（由申请人提供）：随着人口老龄化，与年龄相关的疾病如糖尿病、心血管疾病、痴呆和癌症的社会影响和成本将显著增加。基础衰老研究最初集中在描述衰老的特征，最近则集中在调节寿命的机制上。目前正在采取干预措施的初步步骤，主要是在寿命方面。基础生物学家和临床老年病学家之间很少有交流。临床老年病学研究更多地集中在功能和虚弱上。考虑到老年人数量的增加和医疗保健系统巨大的经济压力，将我们对寿命机制的理解的重大进展从临床应用到临床应用的需求是巨大的。老龄化研究需要扩大到包括转化努力，以加强对增加健康寿命和功能的干预措施的关注，而不仅仅是寿命。我们提议召开一个为期三天的会议，以提供一个论坛，讨论我们如何开始将衰老基础生物学中有希望的最新发现转化为临床相关的治疗策略，以增加健康寿命。本次会议将开始促进基础研究人员和临床研究人员之间的互动，他们专注于开发延长健康寿命、延缓衰弱和延长寿命的干预措施。会议将通过创建一个框架来促进基础科学家和临床医生之间的翻译和合作，从而开辟新的领域，具体目标如下：1)提供一个论坛，概述衰老基础生物学的研究成果，并讨论它们如何与临床实践相关联；2)促进基础研究从业者与临床老年病学家之间的联系；3)促进成熟研究者与年轻研究者之间的互动，包括基础科学家和临床医生。讨论的主题将与转化研究相关：细胞衰老、动物模型、治疗靶点、虚弱和临床需求。

DESCRIPTION (provided by applicant): As the population ages, the societal implications and costs of age-related diseases such as diabetes, cardiovascular disease, dementias, and cancer will increase significantly. Basic aging research was initially focused on describing features of aging and more recently on mechanisms modulating lifespan. Initial steps towards interventions are being taken, mainly with respect to lifespan. There has been little communication between basic biologists and clinical geriatricians. Clinical geriatric research has been much more focused on function and frailty. The need to translate the substantial recent advances in our understanding of mechanisms of lifespan from the bench to the bedside is immense given increasing numbers of older people and huge economic strains on the health care system. Aging research needs to be expanded to encompass a translational effort to enhance focus on interventions that increase healthspan and function, rather than lifespan alone. We propose a three day meeting to provide a forum to discuss how we can begin the process of translating promising recent findings in the basic biology of aging into clinically relevant therapeutic strategies to increase healthspan. This meeting will begin the process of facilitating interactions among basic researchers and clinical investigators who are focused on developing interventions for increasing healthspan, delaying frailty, as well as enhancing lifespan. The meeting will break new ground by creating a framework to facilitate translation and collaboration between basic scientists and clinicians through the following specific aims: 1) To provide a forum to outline findings in the basic biology of aging and discuss how they might relate to clinical practice, 2) To foster links between basic research practitioners and clinical geriatricians, and 3) To facilitate interaction of established investigators with young investigators, both basic scientists and clinicians. Topics addressed will be relevant to translational research: cellular senescence, animal models, therapeutic targets, frailty, and clinical needs. PUBLIC HEALTH RELEVANCE: As the population ages, the societal implications and costs of age-related diseases such as diabetes, cardiovascular disease, dementias, and cancer will significantly increase. The need to translate findings from the bench to the bedside is overwhelming given economic strains on the health care system, increasing numbers of older people, and the substantial advances in our understanding of mechanisms of lifespan. We propose a three day meeting that provides a forum to discuss how promising recent findings in the basic biology of aging can be translated into therapeutic strategies to increase healthspan that may potentially be moved into the clinic.