Innate immunity in premature infants: the role of Toll like receptors in susceptibility to infection

早产儿的先天免疫：Toll 样受体在感染易感性中的作用

• 批准号: nhmrc : 513847
• 负责人: A/Pr Ofer Levy
• 金额: $ 29.36万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/innate-immunity-premature-susceptibility-infection/95376
• 关键词: Innate; immunity; premature; infants; role

Premature infants are extremely vulnerable to severe infection in early life. This study will examine how well premature infants mount an initial immune response against infection (innate immunity) compared to infants born on time and adults. This study will also look at factors that affect this response and whether we can predict which babies will develop severe infection or other complications. This information will help develop new strategies to treat and prevent infections in these infants.

早产儿在生命早期极易受到严重感染。这项研究将检查早产儿对感染（先天免疫）的初始免疫反应与按时出生的婴儿和成年人相比有多好。这项研究还将研究影响这种反应的因素，以及我们是否可以预测哪些婴儿会出现严重感染或其他并发症。这些信息将有助于制定治疗和预防这些婴儿感染的新战略。