Epidemiologic Study of Brain Vitamin E, Diet & Age-Related Neurologic Diseases

脑维生素E、饮食的流行病学研究

• 批准号: 8228079
• 负责人: Martha Clare Morris
• 金额: $ 69.24万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-15 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8228079
• 关键词: Address; Alzheimer' s Disease; Amyloid deposition; Animal Model; Autopsy; Biochemical; Blood; Brain; Brain Diseases; Brain region; Cerebrospinal Fluid; Cerebrum; Clinical; Clinical Trials; Cognitive; Conflict (Psychology); Data; Data Collection; Dementia; Diet; Dietary intake; Disease; Dose; Eating; Elderly; Epidemiologic Studies; Food; Funding; Human; Impaired cognition; Infarction; Inflammation; Inflammatory; Insulin; Intake; Knowledge; Laboratory Animals; Lewy Bodies; Medical History; Motor; Nature; Nervous System Physiology; Neurofibrillary Tangles; Neuroglia; Neurologic; Neurologic Examination; Neurons; Outcome; Oxidative Stress; Parkinson Disease; Parkinsonian Disorders; Participant; Pathologic; Pathology; Persons; Pilot Projects; Plasma; Population; Principal Investigator; Process; Public Health; Relative (related person); Religion and Spirituality; Request for Applications; Risk; Risk Factors; Semantic memory; Severities; Synapses; Testing; Therapeutic Agents; Tocopherols; Vitamin E; Vitamins; Work; age group; age related; alpha Tocopherol; blood glucose regulation; brain tissue; cohort; cost; disorder risk; gamma-Tocopherol; mild neurocognitive impairment; multidisciplinary; nervous system disorder; neuropathology; oxidation; oxidative damage; programs; prospective; relating to nervous system

This is the second revision of an application (1 R01 NS056397), "Epidemiologic Study of Brain Vitamin E, Diet and Age-Related Neurologic Diseases", which was not funded. This application proposes to use data from an existing longitudinal clinical-pathologic study, the Religious Orders study, to analyze biochemical levels of the various forms of vitamin E in post-mortem brain tissue and cerebrospinal fluid in 450 deceased participants as well as selected markers of neuropathology and neural reserve, oxidation, inflammation, and insulin activity, and to collect prospectively annual dietary exposure data on the entire cohort of 800 participants. The Religious Orders Study will provide at no cost to the proposed study, data on all non-dietary risk factors, all clinical outcome data on neurological diseases and cognitive and motor function, and most data on post-mortem neuropathology of brain tissue. Recent studies by this group and others suggest that high-dose a-tocopherol, which is currently being tested in clinical trials, may not be the effective therapeutic agent. If funded, the proposed study will have the unprecedented ability to relate brain levels of the various forms of vitamin E to clinical- pathologic outcomes relevant to Alzheimer's disease (AD) and parkinsonian signs as well as to dietary exposures. The proposed multidisciplinary team conducted a pilot study that suggests brain levels of both gamma and alpha tocopherols are inversely related with AD neuropathology and severity of parkinsonian signs, and positively associated with semantic memory. Substantiation of these associations in the entire cohort would be of the utmost importance to the public health, especially given the debilitating and incurable nature of these diseases, and their high occurrence among the fastest growing age group in the US population. Principal Investigator/Program Director (Last, First, Middle): Morris, Martha Clare This is the second revised R01 application to investigate the relations of tocopherols in the brain to age-related neurological diseases and to dietary tocopherols in an existing longitudinal clinical -pathologic study, the Religious Orders Study.

这是申请（1 R01 NS056397）“脑维生素E、饮食和年龄相关神经系统疾病的流行病学研究”的第二次修订。

项目成果

DASH and Mediterranean-type Dietary Patterns to Maintain Cognitive Health.

• DOI: 10.1007/s13668-013-0070-2
• 发表时间: 2014-03-01
• 期刊: Current nutrition reports
• 影响因子: 4.9
• 作者: Tangney CC

Cognitive reserve, presynaptic proteins and dementia in the elderly.

• DOI: 10.1038/tp.2012.38
• 发表时间: 2012-05-15
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Honer WG;Barr AM;Sawada K;Thornton AE;Morris MC;Leurgans SE;Schneider JA;Bennett DA
• 通讯作者: Bennett DA

Progress in therapy development for amyotrophic lateral sclerosis.

• DOI: 10.1155/2012/187234
• 发表时间: 2012
• 期刊: Neurology research international
• 影响因子: 1.5
• 作者: Venkova-Hristova K;Christov A;Kamaluddin Z;Kobalka P;Hensley K
• 通讯作者: Hensley K

Dietary fat composition and dementia risk.

• DOI: 10.1016/j.neurobiolaging.2014.03.038
• 发表时间: 2014-09
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Morris MC;Tangney CC
• 通讯作者: Tangney CC