MIND Diet Intervention to Prevent Alzheimer's Disease
MIND 饮食干预预防阿尔茨海默病
基本信息
- 批准号:9081135
- 负责人:
- 金额:$ 277.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-04-01 至 2021-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAdverse effectsAffectAgeAlzheimer disease preventionAlzheimer&aposs DiseaseAlzheimer&aposs disease riskAmericanAmyloid beta-ProteinAnimalsAtrophicBerryBiochemicalBiochemical MarkersBiologicalBiological MarkersBlood specimenBody Weight decreasedBostonBrainBrain-Derived Neurotrophic FactorCaloric RestrictionCardiovascular systemCarotenoidsChicagoCholesterolClinicClinical TrialsCognitionCognitiveCounselingDASH dietDNADataDementiaDiabetes MellitusDietDietary ComponentDietary InterventionDietary PracticesDiseaseDoseEpidemiologyEtiologyFamily history ofFishesFolic AcidFoodFoundationsFutureGrapesGuidelinesHeadHippocampus (Brain)HospitalsHybridsHypertensionImpaired cognitionIncidenceIndividualInflammationIntakeInternetInterventionIntervention TrialJuiceLaboratoriesLaboratory StudyLinkMagnetic Resonance ImagingMeasurementMeasuresMediatingMediator of activation proteinMedicineMediterranean DietModificationNational Institute on AgingNerve DegenerationNutrientNutritionalObesityOmega-3 Fatty AcidsOutcomeOverweightOxidative StressParticipantPatientsPhasePhysical activityPlantsPlasmaPopulationPrevalencePreventionPrevention strategyPrevention trialPublic HealthRaceRandomized Controlled TrialsReportingResearch PersonnelRestRisk FactorsRoleSourceSpecific qualifier valueStagingTestingTissuesTrustUniversitiesUnsaturated FatsVegetablesVitaminsWomanage groupagedbasebrain healthbrain volumecardiovascular risk factorchronic depressionclinical practiceclinical research sitecognitive functioncognitive testingcohortcostdesigndietary approachdisorder preventiondrinkinggamma-Tocopherolgood dietlifestyle interventionmetabolomicsmultidisciplinaryneglectneuroimagingnutritionpre-clinicalpreventprimary outcomepsychological distressrandomized trialresponsesaturated fatsextrial designweb site
项目摘要
This R01 application, “MIND Diet Intervention to Prevent Alzheimer Disease,” is a Phase III randomized
controlled trial designed to test the effects of a 3-year intervention of a hybrid of the Mediterranean and DASH
diets, called MIND, on cognitive decline among 600 individuals 65+ years without cognitive impairment who
are overweight and have suboptimal diets. The proposed MIND diet (Mediterranean-DASH Intervention for
Neurodegenerative Delay) is a hybrid of the Mediterranean and DASH diets but with selected modifications
based on the most compelling evidence in the diet-dementia field. The MIND diet has the same basic
components of the DASH and Mediterranean diets, such as emphasis on natural plant-based foods and limited
animal and high saturated fat foods, but uniquely specifies green leafy vegetables and berries as well as food
component servings that reflect the nutrition-dementia evidence. There is a substantial body of evidence from
epidemiological, animal and laboratory studies to link diet to brain health. Thus, the field is primed for the
conduct of a large-scale prevention trial to establish a causal relation between diet and AD prevention.
Establishing such a relation would greatly impact the public health and provide credibility to or refute numerous
claims that various foods and dietary patterns are protective against AD. Dietary guidelines could be
developed from the trial for use in clinical practice to inform patients about disease prevention. The proposed
hybrid diet intervention has demonstrated effects on the prevention and treatment of most of the primary AD
risk factors such as hypertension and diabetes, and the suppression of the two major underlying mechanisms
of AD, oxidative stress and inflammation. The trial will employ a parallel group design comparing the effects on
cognitive outcomes of the MIND intervention diet plus mild caloric restriction for weight loss to the control diet,
usual diet with mild caloric restriction for weight loss. Biological effects of the MIND diet will be assessed by
measurement of brain macro- and micro-structural integrity in 300 randomly selected participants. Other
biochemical markers will be assessed in the entire cohort of 600 participants, including: plasma Abeta
42/Abeta 40, brain-derived neurotrophic factor (BDNF) and plasma markers of oxidative stress and
inflammation. In addition, the trial will examine potential effect mediators and modifiers by a number of
cardiovascular risk factors, AD biomarkers, and biological mechanisms. The proposed study has two clinical
sites, one in Chicago (Rush University) and one in Boston (Harvard University), and centralized laboratories for
data coordinating and analyses (Brigham & Women’s Hospital), neuroimaging analyses (Rush University), and
specialized laboratories for tissue biochemical analyses.
这项R01应用名为“MIND饮食干预预防阿尔茨海默病”,是一项III期随机研究
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Martha Clare Morris其他文献
lifestyle factors and risk of dementia
生活方式因素和痴呆风险
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Martha Clare Morris;K. R. Rama Krishnan;M. Villanueva - 通讯作者:
M. Villanueva
Improving Methodological Standards in Behavioral Interventions for Cognitive Enhancement
- DOI:
10.1007/s41465-018-0115-y - 发表时间:
2019-01-08 - 期刊:
- 影响因子:1.400
- 作者:
C. Shawn Green;Daphne Bavelier;Arthur F. Kramer;Sophia Vinogradov;Ulrich Ansorge;Karlene K. Ball;Ulrike Bingel;Jason M. Chein;Lorenza S. Colzato;Jerri D. Edwards;Andrea Facoetti;Adam Gazzaley;Susan E. Gathercole;Paolo Ghisletta;Simone Gori;Isabela Granic;Charles H. Hillman;Bernhard Hommel;Susanne M. Jaeggi;Philipp Kanske;Julia Karbach;Alan Kingstone;Matthias Kliegel;Torkel Klingberg;Simone Kühn;Dennis M. Levi;Richard E. Mayer;Anne Collins McLaughlin;Danielle S. McNamara;Martha Clare Morris;Mor Nahum;Nora S. Newcombe;Rogerio Panizzutti;Ruchika Shaurya Prakash;Albert Rizzo;Torsten Schubert;Aaron R. Seitz;Sarah J. Short;Ilina Singh;James D. Slotta;Tilo Strobach;Michael S. C. Thomas;Elizabeth Tipton;Xin Tong;Haley A. Vlach;Julie Loebach Wetherell;Anna Wexler;Claudia M. Witt - 通讯作者:
Claudia M. Witt
Martha Clare Morris的其他文献
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{{ truncateString('Martha Clare Morris', 18)}}的其他基金
MIND Diet Intervention to Prevent Alzheimer's Disease
MIND 饮食干预预防阿尔茨海默病
- 批准号:
9792939 - 财政年份:2016
- 资助金额:
$ 277.31万 - 项目类别:
MIND Diet Intervention to Prevent Alzheimer's Disease
MIND 饮食干预预防阿尔茨海默病
- 批准号:
9540976 - 财政年份:2016
- 资助金额:
$ 277.31万 - 项目类别:
Influence of Dietary Fish and mercury Exposure on Brain health and Dementia
膳食鱼类和汞暴露对大脑健康和痴呆症的影响
- 批准号:
8523413 - 财政年份:2012
- 资助金额:
$ 277.31万 - 项目类别:
Influence of Dietary Fish and mercury Exposure on Brain health and Dementia
膳食鱼类和汞暴露对大脑健康和痴呆症的影响
- 批准号:
8260025 - 财政年份:2012
- 资助金额:
$ 277.31万 - 项目类别:
Epidemiologic Study of Brain Vitamin E, Diet & Age-Related Neurologic Diseases
脑维生素E、饮食的流行病学研究
- 批准号:
7368669 - 财政年份:2008
- 资助金额:
$ 277.31万 - 项目类别:
Epidemiologic Study of Brain Vitamin E, Diet & Age-Related Neurologic Diseases
脑维生素E、饮食的流行病学研究
- 批准号:
8228079 - 财政年份:2008
- 资助金额:
$ 277.31万 - 项目类别:
Epidemiologic Study of Brain Vitamin E, Diet & Age-Related Neurologic Diseases
脑维生素E、饮食的流行病学研究
- 批准号:
7584094 - 财政年份:2008
- 资助金额:
$ 277.31万 - 项目类别:
Epidemiologic Study of Brain Vitamin E, Diet & Age-Related Neurologic Diseases
脑维生素E、饮食的流行病学研究
- 批准号:
7795162 - 财政年份:2008
- 资助金额:
$ 277.31万 - 项目类别:
Epidemiologic Study of Brain Vitamin E, Diet & Age-Related Neurologic Diseases
脑维生素E、饮食的流行病学研究
- 批准号:
8042627 - 财政年份:2008
- 资助金额:
$ 277.31万 - 项目类别:
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