Clinical and Administrative

项目总结(见说明)： 临床和行政核心为整个PPG提供基本的业务职能。该中心将招募额颞叶痴呆(FTD)、语义性痴呆(SD)、进行性非流利失语症(PNFA)、进行性核上性麻痹(PSP)、皮质基底膜变性(CBD)、肌营养不良等患者 侧索硬化症(ALS)、阿尔茨海默病(AD)和正常对照组。每个受试者都将接受一项全面的评估，测量范围广泛的神经学、神经心理学、功能、神经行为和社会个性变量。此外，受试者将每年被跟踪收集纵向数据，并在我们的尸检计划中保持较高的入学率。这一核心的管理职能 包括建立政策和程序的基础设施，在私营部门小组内部以及私营部门小组与科学界之间保持沟通，确保私营部门小组资源的最佳利用和监测，并确保所有私营部门小组做法的科学和道德完整性。一旦被招募到 对于临床和行政核心，受试者将被转介到核心E(罗森博士)进行成像和项目2(成像；韦纳博士)、3(情绪；莱文森博士)、4(临床诊断；米勒博士)和6(网络生物标记物；西利博士)。此外，血液样本将被送往遗传学核心(Geschind博士)，尸检组织将被送往病理核心(Seeley&Trojanowski博士)。

PROJECT SUMMARY (See instructions): The Clinical and Administrative Core provides essential operational functions for the entire PPG. This Core will recruit patients with frontotemporal dementia (FTD), semantic dementia (SD), progressive non-fluent aphasia (PNFA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and normal control subjects. Each subject will receive a comprehensive evaluation measuring a broad range of neurological, neuropsychological, functional, neurobehavioral, and social-personality variables. In addition, subjects will be followed annually to collect longitudinal data and maintain high enrollment in our autopsy program. Administrative functions of this Core include the infrastructure for establishing policies and procedures, maintaining communication within the PPG and between the PPG and the scientific community, ensuring optimal utilization and monitoring of PPG resources, and ensuring the scientific and ethical integrity of all PPG practices. Once recruited into the Clinical and Administrative Core, subjects will be referred to Core E (Dr. Rosen) for imaging and Projects 2 (Imaging; Dr. Weiner), 3 (Emotion; Dr. Levenson), 4 (Clinical Diagnosis; Dr. Miller), and 6 (Network Biomarkers; Dr. Seeley). In addition, blood samples will be sent to the Genetics Core (Dr. Geschwind) and autopsy tissue will be sent to the Pathology Core (Drs. Seeley & Trojanowski).