Cardiovascular and Metabolic Risk Factors Associated with Short Sleep Duration

描述（由申请人提供）：流行病学和实验研究中有越来越多的证据表明，除了这些较大的文献外，还有一些研究直接和更深入地研究了短睡眠者现象，但这些研究并没有解决健康相关的结果。研究：在这个K奖中提出的研究旨在成为更大的研究计划的第一步，该计划将在流行病学和实验领域之间架起桥梁。这将最终允许（1）识别处于短睡眠不良影响风险中的个体，（2）旨在改善睡眠不足的不良心脏代谢影响的行为干预措施的开发，以及（3）检测真正的短睡眠者和使他们抵抗短睡眠不良影响的品质。拟议的研究利用大规模调查（n=1200）招募60名受试者（40名短时间睡眠者和20名正常睡眠者），在两个www.example.com中进行评估phases.report短睡眠有许多负面心血管和代谢健康结果的风险。这些研究，在评价样本轨枕短的局限性。 具有开创性和突破性，而流行病学睡眠者短聚集体和评估项目）（单一非标准使用通常研究可能非常异质的样本。实验研究，而高度控制和人口的同质睡眠偏类似更多的是，国家产生的操纵从事样本，剥夺比自然发生的短睡眠. 第一阶段是一项为期2周的家庭研究，将用于前瞻性地证实受试者关于睡眠时间的调查反应，筛查睡眠呼吸障碍，并收集血压数据。第二阶段，一项3晚的实验室研究，将用于收集睡眠连续性和睡眠结构（通过多导睡眠图）、嗜睡（通过多次睡眠潜伏期测试）、精神状态表现（通过精神状态警戒任务）、主动脉葡萄糖稳态（通过口服葡萄糖耐量测试）和生物标志物（包括致动脉粥样硬化脂蛋白，即，HDL和LDL）、IL-6、CRP、瘦素和饥饿素。基于实验室的数据将用于（1）确定短时间睡眠者和正常时间睡眠者在睡眠、嗜睡/表现和心脏代谢功能的客观测量方面是否存在差异，以及（2）探索（初步）短睡眠者队列中的亚组是否解释了睡眠时间与健康之间的关联。脉搏波速度（通过动脉张力测量），培训：K23的这一部分包括使申请人能够制定拟议研究计划所需的教学和指导经验。培训计划建立在申请人的健康心理学背景之上，并为他提供心血管和代谢生理学方面的必要培训，以解决睡眠不足的行为表型是否以及如何与负面健康结果相关。教学方法包括常规的一对一的指导，课程工作，实验室为基础的实践，并在翻译研究硕士学位课程的完成。

DESCRIPTION (provided by applicant): There is growing evidence from epidemiological and experimental studies that individuals who Apart from these larger literatures, there are a few studies that have investigated the short sleeper phenomenon directly and more intensively, but these do not address health-related outcomes. Research: The study proposed within this K-Award is intended to be a first step in a larger program of research that will serve to bridge between the epidemiologic and experimental domains. This will ultimately allow for (1) Identification of individuals that are at risk for the ill effects of short sleep, (2) Development f behavioral interventions aimed at ameliorating adverse cardiometabolic effects of insufficient sleep, and (3) Detection of individuals that are true short sleepers and the qualities that make them resistant to the ill effects of short sleep. The proposed study utilizes a large-scale survey (n=1200) to recruit 60 subjects (40 short and 20 normal duration sleepers) to be assessed in two phases.report short sleep are at risk for a number of negative cardiovascular and metabolic health outcomes. These studies, in evaluated samples sleeper short The limitations. have seminal, and groundbreaking while epidemiological sleeper short aggregate and assessments item) (single nonstandard use often studies samples that are likely very heterogeneous. The experimental studies, while highly controlled and populated by homogenous sleep partial to similar more is that state a produce that manipulations engage samples, deprivation than naturally-occurring short sleep. Phase 1, a 2-week home-based study, will be used to prospectively corroborate subjects' survey responses regarding sleep duration, to screen for sleep-disordered breathing, and to gather blood pressure data. Phase-2, a 3-night, in-lab study, will be used to gather standardized measures of sleep continuity and sleep architecture (via polysomnography), sleepiness (via a Multiple Sleep Latency Test), psychomotor performance (via the Psychomotor Vigilance Task), aortic glucose homeostasis (via an Oral Glucose Tolerance Test) and biomarkers including atherogenic lipoproteins (i.e., HDL and LDL), IL-6, CRP, leptin and ghrelin. The lab-based data will be used to (1) Determine whether short and normal duration sleepers differ on objective measures of sleep, sleepiness/performance, and cardiometabolic function, and (2) Explore (in a preliminary way) whether subgroups within the short sleeper cohort account for the association between sleep duration and health. pulse wave velocity (via arterial tonometry), Training: This component of the K23 is comprised of the didactic and mentored experiences required to enable the applicant to develop the proposed program of research. The training plan builds upon the applicant's background in Health Psychology and provides him the necessary training in cardiovascular and metabolic physiology to address if and how the behavioral phenotype of short sleep is associated with negative health outcomes. The pedagogic approach includes routine one-on-one mentorship, course work, lab-based practica, and completion of a Masters degree program in Translational Research.