Cardiovascular and Metabolic Risk Factors Associated with Short Sleep Duration

与短睡眠时间相关的心血管和代谢危险因素

• 批准号: 8374257
• 负责人: Michael A Grandner
• 金额: $ 16.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8374257
• 关键词: Accounting; Address; Affect; Architecture; Behavior Therapy; Behavioral; Biological Markers; Blood; Blood Pressure; Body mass index; Cardiovascular system; Cholesterol; Circadian Rhythms; Data; Databases; Detection; Development; Effectiveness; Epidemiologic Studies; Epidemiology; Exhibits; Future; Goals; Health; Health Psychology; Heart; High Density Lipoproteins; Home environment; Hour; Impairment; Individual; Inflammatory; Insulin Resistance; Interleukin-6; Intervention; Intrinsic Sleep Disorders; K-Series Research Career Programs; Lead; Leptin; Lipoproteins; Literature; Low-Density Lipoproteins; Master' s Degree; Measures; Mentors; Mentorship; Metabolic; Motor Vehicles; OGTT; Obesity; Outcome; Outcome Study; Patient Self-Report; Performance; Phase; Phenotype; Physiologic pulse; Physiology; Polysomnography; Population; Psychomotor Performance; Recruitment Activity; Relative (related person); Reporting; Research; Resistance; Risk; Risk Factors; Sampling; Sampling Studies; Schedule; Screening procedure; Seminal; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Sleep disturbances; Staging; Subgroup; Surveys; Testing; Time; Training; Translational Research; Triglycerides; Work; actigraphy; arterial tonometry; base; blood glucose regulation; cardiovascular risk factor; cohort; deprivation; design; diaries; experience; ghrelin; glucose tolerance; high risk; indexing; inflammatory marker; insulin sensitivity; low density lipoprotein triglyceride; obesity risk; programs; research study; response; standardize measure; vigilance

DESCRIPTION (provided by applicant): There is growing evidence from epidemiological and experimental studies that individuals who Apart from these larger literatures, there are a few studies that have investigated the short sleeper phenomenon directly and more intensively, but these do not address health-related outcomes. Research: The study proposed within this K-Award is intended to be a first step in a larger program of research that will serve to bridge between the epidemiologic and experimental domains. This will ultimately allow for (1) Identification of individuals that are at risk for the ill effects of short sleep, (2) Development f behavioral interventions aimed at ameliorating adverse cardiometabolic effects of insufficient sleep, and (3) Detection of individuals that are true short sleepers and the qualities that make them resistant to the ill effects of short sleep. The proposed study utilizes a large-scale survey (n=1200) to recruit 60 subjects (40 short and 20 normal duration sleepers) to be assessed in two phases.report short sleep are at risk for a number of negative cardiovascular and metabolic health outcomes. These studies, in evaluated samples sleeper short The limitations. have seminal, and groundbreaking while epidemiological sleeper short aggregate and assessments item) (single nonstandard use often studies samples that are likely very heterogeneous. The experimental studies, while highly controlled and populated by homogenous sleep partial to similar more is that state a produce that manipulations engage samples, deprivation than naturally-occurring short sleep. Phase 1, a 2-week home-based study, will be used to prospectively corroborate subjects' survey responses regarding sleep duration, to screen for sleep-disordered breathing, and to gather blood pressure data. Phase-2, a 3-night, in-lab study, will be used to gather standardized measures of sleep continuity and sleep architecture (via polysomnography), sleepiness (via a Multiple Sleep Latency Test), psychomotor performance (via the Psychomotor Vigilance Task), aortic glucose homeostasis (via an Oral Glucose Tolerance Test) and biomarkers including atherogenic lipoproteins (i.e., HDL and LDL), IL-6, CRP, leptin and ghrelin. The lab-based data will be used to (1) Determine whether short and normal duration sleepers differ on objective measures of sleep, sleepiness/performance, and cardiometabolic function, and (2) Explore (in a preliminary way) whether subgroups within the short sleeper cohort account for the association between sleep duration and health. pulse wave velocity (via arterial tonometry), Training: This component of the K23 is comprised of the didactic and mentored experiences required to enable the applicant to develop the proposed program of research. The training plan builds upon the applicant's background in Health Psychology and provides him the necessary training in cardiovascular and metabolic physiology to address if and how the behavioral phenotype of short sleep is associated with negative health outcomes. The pedagogic approach includes routine one-on-one mentorship, course work, lab-based practica, and completion of a Masters degree program in Translational Research.

描述(申请人提供)：流行病学和实验研究提供的越来越多的证据表明，除了这些较大的文献外，还有一些研究直接和更深入地研究了短睡者现象，但这些研究没有涉及与健康相关的结果。研究：在这个K奖中提出的这项研究旨在成为一个更大的研究计划的第一步，该计划将在流行病学和实验领域之间架起桥梁。这最终将有助于(1)识别有可能受到短睡眠不良影响的个人，(2)开发旨在改善睡眠不足对心脏代谢不利影响的行为干预措施，以及(3)检测真正的短睡者以及使他们能够抵抗短睡眠不良影响的品质。这项拟议的研究利用大规模调查(n=1200)招募了60名受试者(40名短睡者和20名正常睡眠者)，分两个阶段进行评估。报告称，睡眠不足会导致一些负面的心血管和代谢健康后果。这些研究，在评估样本中睡眠不足的局限性。具有开创性、开创性而流行病学沉睡的短汇总和评估项目)(单一的非标准使用通常研究可能非常不同的样本。在实验研究中，虽然高度控制和填充的同质睡眠偏相似，但更多的是一种状态，即操作产生的样本，剥夺比自然发生的短睡眠。第一阶段是一项为期两周的家庭研究，将用于前瞻性地证实受试者关于睡眠持续时间的调查反应，筛查睡眠障碍呼吸，并收集血压数据。第二阶段是一项为期3晚的实验室研究，将用于收集睡眠连续性和睡眠结构(通过多导睡眠图)、困倦(通过多重睡眠潜伏期测试)、精神运动表现(通过精神运动警戒任务)、主动脉血糖稳态(通过口服葡萄糖耐量测试)以及包括致动脉粥样硬化脂蛋白(即高密度脂蛋白和低密度脂蛋白)、IL-6、CRP、瘦素和Ghrelin在内的生物标记物的标准化测量结果。基于实验室的数据将被用来(1)确定短睡者和正常睡眠者在睡眠、嗜睡/表现和心脏代谢功能的客观测量上是否存在差异，以及(2)初步探索短睡眠者队列中的亚组是否考虑了睡眠时间和健康之间的关联。脉搏波速度(通过动脉测压)，训练：K23的这一部分由教学和指导经验组成，使申请者能够开发建议的研究计划。培训计划建立在申请人的健康心理学背景基础上，并为他提供必要的心血管和代谢生理学培训，以解决睡眠不足的行为表型是否以及如何与负面健康结果相关。教学方法包括常规的一对一辅导、课程作业、基于实验室的实践，以及完成翻译研究的硕士学位课程。