Cardiovascular and Metabolic Risk Factors Associated with Short Sleep Duration

描述（由申请人提供）：流行病学和实验研究中越来越多的证据表明，除了这些较大的文献外，还有一些研究直接和更深入地调查了短睡眠现象，但这些研究并未涉及与健康相关的结果。研究：在这个k奖中提出的研究旨在成为一个更大的研究计划的第一步，该计划将在流行病学和实验领域之间架起桥梁。这最终将允许(1)识别有短睡眠不良影响风险的个体，(2)制定旨在改善睡眠不足对心脏代谢不良影响的行为干预措施，以及(3)检测真正的短睡眠者以及使他们能够抵抗短睡眠不良影响的品质。本研究采用大规模调查（n=1200），招募60名受试者（40名短睡眠者和20名正常睡眠者），分两个阶段进行评估。报告称，睡眠不足会对心血管和代谢健康产生负面影响。这些研究，在评估样本睡眠不足的局限性。在流行病学睡眠者短汇总和评估项目时具有开创性和开创性(单一非标准使用往往研究可能非常异质的样本。这些实验研究虽然受到高度控制，并由同质睡眠组成，但部分相似的睡眠更像是一种操纵样本的产物，剥夺了自然发生的短睡眠。第一阶段是一项为期两周的以家庭为基础的研究，将用于前瞻性地证实受试者关于睡眠时间的调查反应，筛查睡眠呼吸障碍，并收集血压数据。第二阶段是一项为期3晚的实验室研究，将用于收集睡眠连续性和睡眠结构（通过多导睡眠图）、嗜睡（通过多次睡眠潜伏期测试）、精神运动表现（通过精神运动警觉性任务）、主动脉葡萄糖稳态（通过口服葡萄糖耐量测试）和生物标志物，包括致动脉粥样硬化脂蛋白（即HDL和LDL）、IL-6、CRP、瘦素和胃饥饿素。基于实验室的数据将用于(1)确定短睡眠者和正常睡眠者在睡眠、困倦/表现和心脏代谢功能的客观测量上是否存在差异，以及(2)（以初步的方式）短睡眠者队列中的亚组是否解释了睡眠时间与健康之间的关联。培训：K23的这一部分由教学和指导经验组成，使申请人能够发展拟议的研究计划。该培训计划建立在申请人健康心理学背景的基础上，并为他提供心血管和代谢生理学方面的必要培训，以解决短睡眠的行为表型是否以及如何与负面健康结果相关。教学方法包括常规的一对一指导、课程作业、实验室实践和完成翻译研究硕士学位课程。

DESCRIPTION (provided by applicant): There is growing evidence from epidemiological and experimental studies that individuals who Apart from these larger literatures, there are a few studies that have investigated the short sleeper phenomenon directly and more intensively, but these do not address health-related outcomes. Research: The study proposed within this K-Award is intended to be a first step in a larger program of research that will serve to bridge between the epidemiologic and experimental domains. This will ultimately allow for (1) Identification of individuals that are at risk for the ill effects of short sleep, (2) Development f behavioral interventions aimed at ameliorating adverse cardiometabolic effects of insufficient sleep, and (3) Detection of individuals that are true short sleepers and the qualities that make them resistant to the ill effects of short sleep. The proposed study utilizes a large-scale survey (n=1200) to recruit 60 subjects (40 short and 20 normal duration sleepers) to be assessed in two phases.report short sleep are at risk for a number of negative cardiovascular and metabolic health outcomes. These studies, in evaluated samples sleeper short The limitations. have seminal, and groundbreaking while epidemiological sleeper short aggregate and assessments item) (single nonstandard use often studies samples that are likely very heterogeneous. The experimental studies, while highly controlled and populated by homogenous sleep partial to similar more is that state a produce that manipulations engage samples, deprivation than naturally-occurring short sleep. Phase 1, a 2-week home-based study, will be used to prospectively corroborate subjects' survey responses regarding sleep duration, to screen for sleep-disordered breathing, and to gather blood pressure data. Phase-2, a 3-night, in-lab study, will be used to gather standardized measures of sleep continuity and sleep architecture (via polysomnography), sleepiness (via a Multiple Sleep Latency Test), psychomotor performance (via the Psychomotor Vigilance Task), aortic glucose homeostasis (via an Oral Glucose Tolerance Test) and biomarkers including atherogenic lipoproteins (i.e., HDL and LDL), IL-6, CRP, leptin and ghrelin. The lab-based data will be used to (1) Determine whether short and normal duration sleepers differ on objective measures of sleep, sleepiness/performance, and cardiometabolic function, and (2) Explore (in a preliminary way) whether subgroups within the short sleeper cohort account for the association between sleep duration and health. pulse wave velocity (via arterial tonometry), Training: This component of the K23 is comprised of the didactic and mentored experiences required to enable the applicant to develop the proposed program of research. The training plan builds upon the applicant's background in Health Psychology and provides him the necessary training in cardiovascular and metabolic physiology to address if and how the behavioral phenotype of short sleep is associated with negative health outcomes. The pedagogic approach includes routine one-on-one mentorship, course work, lab-based practica, and completion of a Masters degree program in Translational Research.