Objective Physical Activity and Cardiovascular Health in Women Aged 80 and Older

80 岁及以上女性的客观体力活动和心血管健康

基本信息

批准号：
8324552
负责人：
ANDREA Z. LACROIX
金额：
$ 172.68万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8324552
关键词：
Address Aerobic African American Age Alzheimer&apos s Disease American Americas Biological Markers Calibration Cardiovascular system Censuses Clinic Clinic Visits Colon Carcinoma Data Dementia Devices Elderly Energy Metabolism Enrollment Event Female Frequencies Future Guidelines Health Health Benefit Health Policy Hispanics Hour Indirect Calorimetry Inflammatory Injury Label Latino Life Expectancy Light Light Exercise Measurement Measures Medicare Minority Non-Insulin-Dependent Diabetes Mellitus Outcome Outcome Study Parents Participant Patient Self-Report Pattern Physical activity Physical activity scale Population Prospective Studies Public Health Public Policy Questionnaires Recruitment Activity Reporting Research Research Design Rice Risk Sample Size Societies Stroke Time United States Visit Walking Water Woman Women&apos s Health age related aged beneficiary cancer type cardiovascular risk factor cognitive function cohort disability evidence base falls healthy aging malignant breast neoplasm mortality older women sedentary statistics web site

项目摘要

DESCRIPTION (provided by applicant): The purpose of this four year project is to determine how much, how vigorous and what patterns of physical activity are necessary to maintain cardiovascular health among older women. Accelerometers will be used to characterize the amounts and patterns of physical activity. In a cohort of 8000 WHI participants aged 80 and older we will: 1) Determine the association of total volume of physical activity (light, moderate and vigorous) as measured by accelerometry with rates of incident CVD and total mortality; 2) Determine the associations of moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with rates of incident CVD and total mortality; 2.1) Conduct a calibration study designed to determine accelerometry thresholds for women aged 80 and older that distinguish sedentary from light activity and light activity from moderate to vigorous activity in order to make Aim 2 directly relevant to older women; 3) Compare the magnitude and independence of associations between accelerometer measures of physical activity and sedentary time, and self-reported measures of MVPA and sedentary time, with rates of incident CVD and total mortality; and 4) Determine associations of total volume of physical activity, MVPA and sedentary time with rates of fall-related injuries and overall risk for any injury. To accomplish these aims, 8,000 face-to-face visits will be conducted nationwide among women aged 80 and older from the Women's Health Initiative (WHI) who were originally enrolled between 1993-1997. Participants will wear an accelerometer for 7 days, complete a questionnaire containing the CHAMPS and WHI physical activity scales, and the Falls Efficacy Scale, and be followed through at least 2015 (3-4 years) to ascertain study outcomes. For the calibration study, two WHI clinics will recruit 200 women for participation in a clinic visit to measure energy expenditure during various activities using indirect calorimetry. This evidence is crucial for formulating evidence-based physical activity guidelines that pertain to the growing population of older women in the US and worldwide.

描述（由申请人提供）：这四年项目的目的是确定在老年妇女中维持心血管健康的必要体育锻炼的程度和哪些模式。加速度计将用于表征体育活动的数量和模式。在80岁及80岁以上的8000名参与者组成的队列中，我们将：1）确定通过加速度计与入射CVD和总死亡率衡量的体育活动总量（轻，中度和剧烈）的关联； 2）确定中度到毒性强度的体育活动（MVPA）和久坐时间与入射CVD和总死亡率的关联； 2.1）进行一项校准研究，旨在确定80岁及80岁及以上的女性的加速度计量学阈值，从而将久坐的活动与轻度活动和光活动从中度到剧烈的活动区分开来，以使AIM 2与老年妇女直接相关； 3）比较加速度计测量体育活动和久坐时间之间的关联的幅度和独立性，以及自我报告的MVPA和久坐时间的量度，以及入射CVD和总死亡率的速度； 4）确定体育活动，MVPA和久坐时间与跌倒相关伤害率以及任何伤害的总体风险的关联。为了实现这些目标，在1993 - 1997年间最初在妇女健康计划（WHI）的80岁及以上的妇女中，将在全国范围内进行8,000次面对面访问。参与者将佩戴加速度计7天，填写包含Champs和Whi体育锻炼量表的问卷，以及跌落功效量表，并至少在2015年（3 - 4年）中遵循以确定研究结果。在校准研究中，两家WHI诊所将招募200名女性参加诊所就诊，以使用间接量热法在各种活动中衡量能量支出。该证据对于制定基于证据的体育活动指南至关重要，这些指南与美国和全球范围内的老年妇女人口有关。