Objective Physical Activity and Cardiovascular Health in Women Aged 80 and Older

80 岁及以上女性的客观体力活动和心血管健康

• 批准号: 8324552
• 负责人: ANDREA Z. LACROIX
• 金额: $ 172.68万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324552
• 关键词: Address; Aerobic; African American; Age; Alzheimer' s Disease; American; Americas; Biological Markers; Calibration; Cardiovascular system; Censuses; Clinic; Clinic Visits; Colon Carcinoma; Data; Dementia; Devices; Elderly; Energy Metabolism; Enrollment; Event; Female; Frequencies; Future; Guidelines; Health; Health Benefit; Health Policy; Hispanics; Hour; Indirect Calorimetry; Inflammatory; Injury; Label; Latino; Life Expectancy; Light; Light Exercise; Measurement; Measures; Medicare; Minority; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Outcome Study; Parents; Participant; Patient Self-Report; Pattern; Physical activity; Physical activity scale; Population; Prospective Studies; Public Health; Public Policy; Questionnaires; Recruitment Activity; Reporting; Research; Research Design; Rice; Risk; Sample Size; Societies; Stroke; Time; United States; Visit; Walking; Water; Woman; Women' s Health; age related; aged; beneficiary; cancer type; cardiovascular risk factor; cognitive function; cohort; disability; evidence base; falls; healthy aging; malignant breast neoplasm; mortality; older women; sedentary; statistics; web site

DESCRIPTION (provided by applicant): The purpose of this four year project is to determine how much, how vigorous and what patterns of physical activity are necessary to maintain cardiovascular health among older women. Accelerometers will be used to characterize the amounts and patterns of physical activity. In a cohort of 8000 WHI participants aged 80 and older we will: 1) Determine the association of total volume of physical activity (light, moderate and vigorous) as measured by accelerometry with rates of incident CVD and total mortality; 2) Determine the associations of moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with rates of incident CVD and total mortality; 2.1) Conduct a calibration study designed to determine accelerometry thresholds for women aged 80 and older that distinguish sedentary from light activity and light activity from moderate to vigorous activity in order to make Aim 2 directly relevant to older women; 3) Compare the magnitude and independence of associations between accelerometer measures of physical activity and sedentary time, and self-reported measures of MVPA and sedentary time, with rates of incident CVD and total mortality; and 4) Determine associations of total volume of physical activity, MVPA and sedentary time with rates of fall-related injuries and overall risk for any injury. To accomplish these aims, 8,000 face-to-face visits will be conducted nationwide among women aged 80 and older from the Women's Health Initiative (WHI) who were originally enrolled between 1993-1997. Participants will wear an accelerometer for 7 days, complete a questionnaire containing the CHAMPS and WHI physical activity scales, and the Falls Efficacy Scale, and be followed through at least 2015 (3-4 years) to ascertain study outcomes. For the calibration study, two WHI clinics will recruit 200 women for participation in a clinic visit to measure energy expenditure during various activities using indirect calorimetry. This evidence is crucial for formulating evidence-based physical activity guidelines that pertain to the growing population of older women in the US and worldwide.

描述（由申请人提供）：这个为期四年的项目的目的是确定多少，如何激烈和什么样的体育活动模式是必要的，以保持老年妇女的心血管健康。将使用加速计来表征身体活动的数量和模式。在8000名年龄在80岁及以上的WHI参与者中，我们将：1）确定体力活动总量2）确定中等强度至剧烈强度的体力活动（MVPA）和久坐时间与CVD事件率和总死亡率的关联; 2.1进行一项校准研究，以确定80岁及以上妇女的加速度阈值，区分久坐与轻度活动以及轻度活动与中度至剧烈活动，使目标2与老年妇女直接相关; 3）比较身体活动和久坐时间的加速度计测量之间的关联的幅度和独立性，以及自我报告的MVPA和久坐时间的测量结果，以及CVD事件发生率和总死亡率;以及4）确定体力活动总量、MVPA和久坐时间与跌倒相关损伤率和任何损伤的总体风险的相关性。为了实现这些目标，将在全国范围内对1993-1997年期间参加妇女健康倡议的80岁以上妇女进行8 000次面对面的访问。参与者将佩戴加速计7天，完成一份包含CHAMPS和WHI体力活动量表以及福尔斯疗效量表的问卷，并至少随访至2015年（3-4年），以确定研究结果。对于校准研究，两个WHI诊所将招募200名妇女参加诊所访问，使用间接热量测定法测量各种活动期间的能量消耗。这些证据对于制定基于证据的体力活动指南至关重要，这些指南适用于美国和全球不断增长的老年女性人口。