Center for Reduce CVD Disparities: Genes, Clinics, and Communities

减少 CVD 差异中心：基因、诊所和社区

• 批准号: 8296599
• 负责人: ALICE S AMMERMAN
• 金额: $ 165.46万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8296599
• 关键词: Adoption; Affect; Bioinformatics; Capital; Cardiovascular Diseases; Cardiovascular system; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical; Communities; Counseling; County; Data; Data Collection; Economic Development; Employment; Environment; Funding; Genes; Genetic; Genomics; Health; Health Professional; Health Promotion; Heart Diseases; Home environment; Housing; Hypertension; Individual; Instruction; Interdisciplinary Study; Intervention; Life; Life Style; Low income; Minority; North Carolina; Obesity; Occupations; Outcome; Participant; Pathway interactions; Policies; Population; Poverty; Prevention Research; Public Health; Relative (related person); Risk Factors; Stroke; System; Testing; Time; Translations; Universities; Work; base; cardiovascular disorder risk; community based participatory research; disorder prevention; genetic analysis; health care delivery; improved; innovation; interest; medication compliance; meetings; programs; social

Risk factors for cardiovascular disease (CVD) disproportionately affect low income and minority populations. Lenoir County, North Carolina is among the poorest in the state and situated in the "stroke belt" with significantly elevated heart disease, stroke, and obesity rates relative to state levels already well above the national average. At the same time, this county is home to many clinical and public health efforts on which to build. We propose an integrated set of three interdisciplinary studies in Lenoir County to: 1) determine genetic factors associated with CVD risk; 2) understand the multilevel determinants of poor health outcomes and the potential social and community capital that can support sustainable change; 3) work with community leaders, health professionals, and citizens to apply these understandings to improved practice-based management of hypertension and community-centered lifestyle management, and test the impact on improving outcomes and reducing disparities in cardiovascular health among 700 participants. This will include an innovative partnership with a nonprofit call center, Connect Inc, adding a lifestyle and medication adherence coaching component to their current focus on jobs, employment, and benefits counseling; 4) test the impact, reach, adoption, and sustainability of clinical, community-level, and policy interventions , including economic development potential; and 5) develop and implement strategies for translation and dissemination of the clinic-based and community-level interventions to other underserved regions. This work will be supported by an administrative core housed in the Center for Health Promotion and Disease Prevention (a CDC funded Prevention Research Center with a focus on community-based participatory research). Additional cores include: 1) a Genomic Bioinformatics Core available to this project and other PSO programs to analyze genetic/genomic data and other pathways of interest; and 2) a Social Determinants/Economic Development/Dissemination Core to understand the interface between poverty and health, and explore strategies with the potential to create jobs while promoting health. Additional core support for data collection, community engagement, and economic development will be leveraged through the UNC CTSA (NC TraCS) and the Community-Campus Partnership for Tomorrow, which is the result of a statewide assessment led to the President of the UNC (16 campus) system to "to produce a more proactively responsive University focused on meeting the challenges of the state over the next 20 years."

心血管疾病(CVD)的风险因素对低收入和少数群体的影响不成比例。 北卡罗来纳州的勒诺伊尔县是该州最贫穷的县之一，地处中风带，心脏病、中风和肥胖率相对于该州的水平显著上升，而该州的水平已经远远高于全国平均水平。与此同时，这个县是许多临床和公共卫生努力的发源地，可以在此基础上进行建设。我们建议在勒诺伊尔县进行一套综合的三项跨学科研究：1)确定与心血管疾病风险相关的遗传因素；2)了解不良健康结果的多层次决定因素以及支持可持续变化的潜在社会和社区资本；3)与社区领导人、卫生专业人员和公民合作，将这些理解应用于改进以实践为基础的高血压管理和以社区为中心的生活方式管理，并在700名参与者中测试对改善结果和减少心血管健康差距的影响。这将包括与非营利性呼叫中心Connect Inc.建立创新的合作伙伴关系，在他们目前专注于工作、就业和福利咨询的基础上，增加生活方式和服药依从性培训部分；4)测试 临床、社区一级和政策干预措施的影响、覆盖范围、采用和可持续性，包括经济发展潜力；以及5)制定和实施战略，将诊所和社区一级干预措施翻译和传播到其他服务不足的地区。这项工作将由设在健康促进和疾病预防中心(疾控中心资助的预防研究中心，重点是社区参与性研究)的行政核心提供支助。其他核心包括：1)可用于该项目和其他PSO计划的基因组生物信息学核心，用于分析遗传/基因组数据和其他感兴趣的途径；以及2)社会 决定因素/经济发展/传播核心，以了解贫困与健康之间的联系，并探索有潜力在促进健康的同时创造就业机会的战略。对数据收集、社区参与和经济发展的更多核心支持将通过北卡罗来纳大学CTSA(NC TraCS)和社区-校园明天伙伴关系得到利用，这是全州范围内评估的结果，导致北卡罗来纳大学(16个校园)系统的校长“建立一个更积极主动的响应大学，专注于应对未来20年的州挑战。”