Improved Batteries for Implantable Cardiac Defibrillators

改进的植入式心脏除颤器电池

• 批准号: 8509074
• 负责人: Amy Catherine Marschilok
• 金额: $ 18.64万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-15 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8509074
• 关键词: Anodes; Anxiety; Arrhythmia; Benchmarking; Carbon; Cardiac; Cathodes; Cessation of life; Characteristics; Charge; Clinical; Copper; Defibrillators; Development; Devices; Electrochemistry; Electrolytes; Energy-Generating Resources; Family; Film; Frequencies; Goals; Health; Health Care Costs; Heart Arrest; Implant; Ions; Iron; Iron Compounds; Lead; Life; Lithium; Maintenance; Materials Testing; Medicare; Metals; Monitor; Natural graphite; Operative Surgical Procedures; Organic Iron Compounds; Oxides; Patients; Performance; Phosphorus; Power Sources; Problem Solving; Risk; Scheme; Science; Silver; Simulate; Solubility; Solutions; Stress; Technology; Time; Vanadium; Vanadium Compounds; Work; base; chemical property; cost; heart rhythm; implantable device; improved; inorganic phosphate; middle age; nanowire; patient population; premature; voltage

DESCRIPTION (provided by applicant): There is an ever growing demand for implantable cardiac defibrillators (ICDs), with over 100,000 devices implanted in 2004, and dramatic increases anticipated over the next decade due to expanded indications and coverage by Medicare. The growing level of acceptance of these lives- saving devices has increased the desire for improved ICD function. The lifetime of the average ICD patient after implant has increased to 10 years while the average device lifetime is around 5 years. Thus, most patients require additional surgeries to replace their original device, resulting in both clinical risk and cost. The current benchmark power source technology is lithium/silver vanadium oxide (Li/SVO) developed >20 years ago. Li/SVO battery technology can display a significant midlife decrease in performance termed voltage delay. This voltage delay, a result of cathode solubility and the associated formation of a passivation film on the anode, has caused premature device explants for numerous patients at the 2.5 to 3 year point due to delays in therapy delivery. Along with the added expense of the unplanned surgery, premature device explant can create patient anxiety. Options employed to `work around' Li/SVO voltage delay lead to shortened battery life. The overall project goal is to solve this problem with fundamental science by demonstrating new superior cathode materials that could be used to extend the life and improve the consistency of ICD batteries. The proposed project has three specific objectives: 1) develop a new class of improved battery materials for ICD applications based on metal-metal-phosphorous-oxides of the MwM'xPyOz (MM'PO) family (M = silver or copper; M' = vanadium or iron), 2) test the materials in experimental batteries under simulated use schemes mimicking ICD function, and 3) compare the key characteristics of long term stability (lack of solubility and voltage delay), energy delivery, and energy content with the current battery benchmark technology (Li/SVO). The proposed activity involves the synthesis, characterization and electrochemistry of a new family of materials, MM'POs. We hypothesize that MM'POs will have improved ICD battery performance based on their fundamental chemical properties: reduced solubility of phosphate based materials compared to analogous oxide compounds, high voltage of vanadium or iron compounds yielding high levels of energy delivery, and the inclusion of silver or copper ions in the matrix to provide high volumetric energy content. PUBLIC HEALTH RELEVANCE: Implantable cardiac defibrillators (ICDs) are lifesaving devices which monitor and correct abnormal heart rhythms and have become an increasingly accepted treatment option. The project goal is to create a new class of materials (MM'POs) and demonstrate their superiority to the current benchmark cathode materials for ICD batteries. Ultimately, our MM'POs will extend the life and improve the consistency of ICD batteries, reducing the frequency of device replacements and the associated negative impact on patients and healthcare costs.

描述（由申请人提供）：对植入式心脏除颤器（ICDs）的需求不断增长，2004年植入的设备超过100,000台，由于医疗保险的适应症和覆盖范围的扩大，预计未来十年将大幅增加。越来越多的人接受这些挽救生命的装置，这增加了人们对改进ICD功能的渴望。ICD患者植入后的平均寿命已增加到10年，而设备的平均寿命约为5年。因此，大多数患者需要额外的手术来更换原有的设备，这既增加了临床风险，也增加了成本。目前的基准电源技术是20年前开发的锂/银钒氧化物（Li/SVO）。Li/SVO电池技术可以显示显着的中年性能下降，称为电压延迟。由于阴极溶解度和阳极钝化膜的相关形成，这种电压延迟导致许多患者由于治疗延迟而在2.5至3年内过早植入设备。伴随着计划外手术的额外费用，过早的植入术会引起患者的焦虑。用于“解决”Li/SVO电压延迟的选项导致电池寿命缩短。该项目的总体目标是通过展示新的优质阴极材料来解决这一问题，这些材料可用于延长ICD电池的寿命并提高其一致性。拟议的项目有三个具体目标：1)基于MwM'xPyOz （MM'PO）家族的金属-金属-磷氧化物(M =银或铜；M' =钒或铁),2)在模拟ICD功能的模拟使用方案下测试实验电池中的材料，以及3)将长期稳定性（缺乏溶解度和电压延迟），能量输送和能量含量的关键特性与当前电池基准技术（Li/SVO）进行比较。提议的活动涉及一个新的材料家族，MM'POs的合成，表征和电化学。我们假设，基于其基本化学性质，MM'POs将改善ICD电池的性能：与类似的氧化物化合物相比，磷酸盐基材料的溶解度降低，钒或铁化合物的高电压产生高水平的能量传递，以及在基体中包含银或铜离子以提供高体积能量含量。公共卫生相关性：植入式心脏除颤器（ICDs）是监测和纠正异常心律的救命装置，已成为越来越被接受的治疗选择。该项目的目标是创造一种新型材料（MM'POs），并展示其相对于当前ICD电池基准正极材料的优势。最终，我们的MM' po将延长ICD电池的使用寿命并提高其一致性，减少设备更换的频率以及对患者和医疗保健成本的相关负面影响。

项目成果

Silver Vanadium Phosphorous Oxide, Ag(2)VO(2)PO(4): Chimie Douce Preparation and Resulting Lithium Cell Electrochemistry.

• DOI: 10.1016/j.jpowsour.2010.10.054
• 发表时间: 2011-08-15
• 期刊: JOURNAL OF POWER SOURCES
• 影响因子: 9.2
• 作者: Kim, Young Jin;Marschilok, Amy C.;Takeuchi, Kenneth J.;Takeuchi, Esther S.
• 通讯作者: Takeuchi, Esther S.

A Kinetics and Equilibrium Study of Vanadium Dissolution from Vanadium Oxides and Phosphates in Battery Electrolytes: Possible Impacts on ICD Battery Performance.

• DOI: 10.1016/j.jpowsour.2013.01.012
• 发表时间: 2013-06-01
• 期刊: JOURNAL OF POWER SOURCES
• 影响因子: 9.2
• 作者: Bock, David C.;Marschilok, Amy C.;Takeuchi, Kenneth J.;Takeuchi, Esther S.
• 通讯作者: Takeuchi, Esther S.

Silver vanadium oxide and silver vanadium phosphorous oxide dissolution kinetics: a mechanistic study with possible impact on future ICD battery lifetimes.

• DOI: 10.1039/c3dt51544c
• 发表时间: 2013-09
• 期刊: Dalton transactions
• 影响因子: 4
• 作者: D. Bock;K. Takeuchi;A. Marschilok;E. Takeuchi

Electrochemical Reduction of Silver Vanadium Phosphorous Oxide, Ag(2)VO(2)PO(4): Silver Metal Deposition and Associated Increase in Electrical Conductivity.

• DOI: 10.1016/j.jpowsour.2010.04.033
• 发表时间: 2010-10-01
• 期刊: Journal of power sources
• 影响因子: 9.2
• 作者: Marschilok AC;Kozarsky ES;Tanzil K;Zhu S;Takeuchi KJ;Takeuchi ES
• 通讯作者: Takeuchi ES

Synthetic control of composition and crystallite size of silver hollandite, Ag(x)Mn8O16: impact on electrochemistry.

• DOI: 10.1021/am301443g
• 发表时间: 2012-10-24
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Takeuchi, Kenneth J.;Yau, Shali Z.;Menard, Melissa C.;Marschilok, Amy C.;Takeuchi, Esther S.
• 通讯作者: Takeuchi, Esther S.