Pathology and Biorepository Core

病理学和生物样本库核心

• 批准号: 8588575
• 负责人: KENNETH D ALDAPE
• 金额: $ 15.15万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8588575
• 关键词: Animals; Biological Markers; Biology; Blood specimen; Brain Neoplasms; Cancer Center; Caring; Cell Culture Techniques; Cells; Central Nervous System Neoplasms; Clinical; Collaborations; DNA; Data; Databases; Doctor of Medicine; Evaluation; Experimental Neoplasms; Foundations; Glioma; Histologic; Instruction; Investigation; Malignant neoplasm of brain; Nervous system structure; Normal tissue morphology; Pathologic; Pathology; Patients; Process; Proteins; RNA; Research; Research Personnel; Resources; Sampling; Services; Specimen; Stem cells; Tissue Microarray; Tissue Sample; Tissues; Translational Research; Tumor Tissue; University of Texas M D Anderson Cancer Center; biobank; design and construction; human tissue; improved; meetings; programs; prospective; repository; tissue resource; treatment effect; tumor

A fundamental component of the translational research of the The University of Texas MD Anderson Cancer Center Brain Cancer SPORE is conduct of focused translational research involving human tissue and blood specimens, allowing investigation of the biology of target and normal tissues, and evaluation of treatment effects on both target and normal tissue and on modulation of specific, relevant biomarkers. The Pathology and Biorepository Core collects, processes and maintains human tissue specimens from patients and will disperse these tissues and tissue-derived primary glioma stem cell (GSC) to SPORE investigators. It has been an effective resource for the existing SPORE projects, which are heavily tissue- dependent and will continue to serve this function in the proposed SPORE Projects going forward. The specific objectives of the Pathology and Biorepository Core are these: Objective 1 Maintain and enhance a repository of tumor tissue and matched blood specimens from patients with central.nervous system (CNS) tumors receiving care at MD Anderson Cancer Center Objective 2 Provide comprehensive histologic characterization of tissue samples used in SPORE projects, including specimens from patients and experimental tumors in animals; expeditiously distribute tissue specimens to SPORE investigators for analysis and provide expertise in the interpretation of studies performed on tissue sections within SPORE projects Objective 3 Offer centralized services, including immunohistochemical characterization of biomarkers, tissue array design and construction and primary GSC culture of tumor samples where appropriate. Objective 4 Support a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with CNS tumors receiving care or evaluation at MD Anderson Cancer Center Objective 5 Facilitate inter-SPORE collaborations through sharing of tissue resources RELEVANCE (See instructions): DO NOT EXCEED THE SPACE PROVIDED. Research into brain cancer depends on the availability of tumor samples obtained from patients. These samples and the DNA, RNA, proteins, and cells derived from them (e.g. GSCs) are the foundation of any translational program. This Core provides the patient samples that are key to understanding and curing brain tumors.

德州大学安德森分校翻译研究的一个基本组成部分 癌症中心脑癌孢子是涉及人体组织的有针对性的翻译研究 和血液样本，允许调查目标组织和正常组织的生物学，并评估 治疗对靶组织和正常组织都有影响，对特定的相关生物标志物的调节也有影响。这个 病理学和生物库核心收集、处理和维护来自 并将这些组织和组织来源的原代胶质瘤干细胞(GSC)分散到孢子中 调查人员。它是现有孢子项目的有效资源，这些项目含有大量的组织- 在未来，它将继续在拟议的孢子项目中发挥这一作用。 病理学和生物库核心的具体目标如下： 目标1维护和增强肿瘤组织和匹配血液样本的存储库 中枢神经系统(CNS)肿瘤患者在MD Anderson癌症中心接受治疗 目的2提供用于孢子培养的组织标本的综合组织学特征 项目，包括病人标本和动物实验性肿瘤；迅速分发 将组织标本交给孢子调查员进行分析，并提供研究解释方面的专业知识 在孢子项目内的组织切片上执行 目标3提供集中服务，包括生物标记物的免疫组织化学表征， 组织阵列的设计和构建以及肿瘤样本的原代GSC培养。 目标4支持一个全面的、前瞻性的交互数据库，其中包含详细的临床和 在MD Anderson癌症中心接受护理或评估的中枢神经系统肿瘤患者的病理数据 目标5通过共享组织资源促进孢子间的合作 相关性(参见说明)：不要超过所提供的空间。 对脑癌的研究取决于从患者身上获得的肿瘤样本的可用性。这些 样本及其DNA、RNA、蛋白质和源自它们的细胞(例如GSCs)是任何 翻译计划。此核心提供患者样本，这些样本是了解和治疗的关键 脑瘤。