Pathology and Biorepository Core

病理学和生物样本库核心

• 批准号: 9128427
• 负责人: KENNETH D ALDAPE
• 金额: $ 15.3万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9128427
• 关键词: Animals; Biological Markers; Biology; Blood specimen; Brain Neoplasms; Cancer Center; Caring; Cell Culture Techniques; Cells; Central Nervous System Neoplasms; Clinical; Collaborations; DNA; Data; Databases; Doctor of Medicine; Evaluation; Experimental Neoplasms; Foundations; Glioma; Histologic; Instruction; Investigation; Malignant neoplasm of brain; Nervous system structure; Normal tissue morphology; Pathologic; Pathology; Patients; Process; Proteins; RNA; Research; Research Personnel; Resources; Sampling; Services; Specimen; Stem cells; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Tissue; University of Texas M D Anderson Cancer Center; biobank; design and construction; human tissue; improved; meetings; programs; prospective; repository; tissue resource; treatment effect; tumor

A fundamental component of the translational research of the The University of Texas MD Anderson Cancer Center Brain Cancer SPORE is conduct of focused translational research involving human tissue and blood specimens, allowing investigation of the biology of target and normal tissues, and evaluation of treatment effects on both target and normal tissue and on modulation of specific, relevant biomarkers. The Pathology and Biorepository Core collects, processes and maintains human tissue specimens from patients and will disperse these tissues and tissue-derived primary glioma stem cell (GSC) to SPORE investigators. It has been an effective resource for the existing SPORE projects, which are heavily tissue- dependent and will continue to serve this function in the proposed SPORE Projects going forward. The specific objectives of the Pathology and Biorepository Core are these: Objective 1 Maintain and enhance a repository of tumor tissue and matched blood specimens from patients with central.nervous system (CNS) tumors receiving care at MD Anderson Cancer Center Objective 2 Provide comprehensive histologic characterization of tissue samples used in SPORE projects, including specimens from patients and experimental tumors in animals; expeditiously distribute tissue specimens to SPORE investigators for analysis and provide expertise in the interpretation of studies performed on tissue sections within SPORE projects Objective 3 Offer centralized services, including immunohistochemical characterization of biomarkers, tissue array design and construction and primary GSC culture of tumor samples where appropriate. Objective 4 Support a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with CNS tumors receiving care or evaluation at MD Anderson Cancer Center Objective 5 Facilitate inter-SPORE collaborations through sharing of tissue resources RELEVANCE (See instructions): DO NOT EXCEED THE SPACE PROVIDED. Research into brain cancer depends on the availability of tumor samples obtained from patients. These samples and the DNA, RNA, proteins, and cells derived from them (e.g. GSCs) are the foundation of any translational program. This Core provides the patient samples that are key to understanding and curing brain tumors.

德克萨斯大学医学博士翻译研究的基本组成部分 癌症中心脑癌孢子是涉及人体组织的重点翻译研究的行为 和血液标本，允许研究目标和正常组织的生物学，并评估 治疗对靶标和正常组织以及对特定相关生物标志物的调节的影响。这 病理和生物座核核心收集，过程和维持人体组织标本 患者并将分散这些组织和组织来源的原发性神经胶质瘤干细胞（GSC） 调查人员。对于现有的孢子项目而言，它一直是组织大量组织的有效资源 - 依赖并将继续在未来的拟议孢子项目中发挥此功能。 病理学和生物措施核心的具体目标是： 目标1维持和增强肿瘤组织的存储库和匹配的血液标本 中枢性系统（CNS）肿瘤在MD Anderson癌症中心接受护理的患者 目标2提供了孢子中使用的组织样品的全面组织学表征 项目，包括来自患者的标本和动物的实验肿瘤；快速分发 组织标本向孢子研究者进行分析并提供研究的专业知识 在孢子项目中的组织部分进行 目标3提供集中服务，包括生物标志物的免疫组织化学特征， 在适当的情况下，组织阵列设计和构造以及肿瘤样品的原发性GSC培养。 目标4支持一个具有详细临床和详细的前瞻性交互式数据库 在MD安德森癌症中心接受护理或评估的中枢神经系统肿瘤患者的病理数据 目标5通过共享组织资源来促进跨间的合作 相关性（请参阅说明）：不要超过提供的空间。 对脑癌的研究取决于从患者获得的肿瘤样本的可用性。这些 样品和DNA，RNA，蛋白质和细胞（例如GSC）是任何人的基础 翻译计划。该核心提供了患者样本，这些样本是理解和治愈的关键 脑肿瘤。