CB: Pathology and Tissue Procurement Core

CB：病理学和组织采购核心

• 批准号: 7450239
• 负责人: KENNETH D ALDAPE
• 金额: $ 12.39万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7450239
• 关键词: Animals; Biological Markers; Biology; Blood specimen; Caring; Central Nervous System Neoplasms; Clinical; Collaborations; Data; Databases; Evaluation; Experimental Neoplasms; Glioma; Histologic; Investigation; Malignant neoplasm of brain; Nervous system structure; Normal tissue morphology; Pathologic; Pathology; Patients; Process; Reproduction spores; Research Personnel; Sampling; Services; Specimen; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Tissue; University of Texas M D Anderson Cancer Center; design and construction; human tissue; improved; prospective; repository; tissue resource; treatment effect; tumor

The specific objectives of the Pathology and Tissue Procurement Core are to: Objective 1 Maintain and enhance a repository of tumor tissue and matched blood specimens from patients with central nervous system (CNS) tumors receiving care at The University of Texas M. D. Anderson Cancer Center (UTMDACC). Objective 2 Provide comprehensive histologic characterization of tissue samples used in the SPORE Projects, including specimens from patients and experimental tumors in animals; expeditiously distribute tissue specimens to SPORE investigators for analysis; and provide expertise in the interpretation of studies performed on tissue sections within the SPORE Projects. Objective 3 Offer centralized services, including immunohistochemical characterization of biomarkers, tissue array design and construction, and primary culture of tumor samples where appropriate. Objective 4 Support a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with CNS tumors receiving care or evaluation at UTMDACC. Objective 5 Facilitate inter-SPORE collaborations through sharing of tissue resources.

病理和组织采购核心的特定目标是： 目标1维持和增强肿瘤组织的存储库和匹配的血液标本 中枢神经系统（CNS）肿瘤接受护理的患者 德州M. D.安德森癌症中心（UTMDACC）。 目标2提供了孢子中使用的组织样品的全面组织学表征 项目，包括来自患者的标本和动物的实验肿瘤； 迅速将组织标本分发给孢子研究人员进行分析；并提供 在孢子内组织切片进行的研究解释方面的专业知识 项目。 目标3提供集中服务，包括生物标志物的免疫组织化学特征， 组织阵列设计和构造，以及肿瘤样品的主要培养 合适的。 目标4支持一个具有详细临床和详细的前瞻性交互式数据库 在UTMDACC接受护理或评估的中枢神经系统肿瘤患者的病理数据。 目标5通过共享组织资源来促进跨间的合作。