CB: Pathology and Tissue Procurement Core

CB：病理学和组织采购核心

• 批准号: 7450239
• 负责人: KENNETH D ALDAPE
• 金额: $ 12.39万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7450239
• 关键词: Animals; Biological Markers; Biology; Blood specimen; Caring; Central Nervous System Neoplasms; Clinical; Collaborations; Data; Databases; Evaluation; Experimental Neoplasms; Glioma; Histologic; Investigation; Malignant neoplasm of brain; Nervous system structure; Normal tissue morphology; Pathologic; Pathology; Patients; Process; Reproduction spores; Research Personnel; Sampling; Services; Specimen; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Tissue; University of Texas M D Anderson Cancer Center; design and construction; human tissue; improved; prospective; repository; tissue resource; treatment effect; tumor

The specific objectives of the Pathology and Tissue Procurement Core are to: Objective 1 Maintain and enhance a repository of tumor tissue and matched blood specimens from patients with central nervous system (CNS) tumors receiving care at The University of Texas M. D. Anderson Cancer Center (UTMDACC). Objective 2 Provide comprehensive histologic characterization of tissue samples used in the SPORE Projects, including specimens from patients and experimental tumors in animals; expeditiously distribute tissue specimens to SPORE investigators for analysis; and provide expertise in the interpretation of studies performed on tissue sections within the SPORE Projects. Objective 3 Offer centralized services, including immunohistochemical characterization of biomarkers, tissue array design and construction, and primary culture of tumor samples where appropriate. Objective 4 Support a comprehensive, prospective interactive database with detailed clinical and pathologic data for patients with CNS tumors receiving care or evaluation at UTMDACC. Objective 5 Facilitate inter-SPORE collaborations through sharing of tissue resources.

病理学和组织采购核心的具体目标是： 目标 1 维护和增强肿瘤组织和匹配血液样本的存储库 中枢神经系统 (CNS) 肿瘤患者在英国大学接受护理 德克萨斯MD安德森癌症中心（UTMDACC）。 目标 2 提供 SPORE 中使用的组织样本的全面组织学特征 项目，包括患者标本和动物实验肿瘤； 迅速将组织标本分发给 SPORE 研究人员进行分析；并提供 解释 SPORE 内组织切片研究的专业知识 项目。 目标 3 提供集中服务，包括生物标志物的免疫组织化学表征、 组织阵列设计和构建，以及肿瘤样本的原代培养 合适的。 目标 4 支持一个全面的、前瞻性的交互式数据库，其中包含详细的临床和 在 UTMDACC 接受护理或评估的中枢神经系统肿瘤患者的病理数据。 目标 5 通过共享组织资源促进 SPORE 之间的合作。