Preventing excessive gestational weight gain in obese women

预防肥胖女性妊娠期体重过度增加

基本信息

批准号：
8732790
负责人：
Suzanne Phelan
金额：
$ 9.5万
依托单位：
CALIFORNIA POLY STATE U SAN LUIS OBISPO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-23 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8732790
关键词：
Adherence Affect Age-Months Apgar Score Behavior Behavior Therapy Behavioral Birth trauma Blood Pressure Body Image Calories Constipation Cromolyn Sodium Diet Disinhibition Eating Environment Equilibrium Ethnic Origin Exercise Fasting Fatty acid glycerol esters Feedback Food Frequencies Gestational Diabetes Glucose Goals Health Hispanics Home environment Incidence Infant Institute of Medicine (U.S.)Instruction Insulin Intake Intervention Length Life Style Lipids Liquid substance Low Birth Weight Infant Measures Modeling Moods Mothers Not Hispanic or Latino Nutritional Obesity Overweight Participant Physical activity Physiological Population Postpartum Period Pre-Eclampsia Pregnancy Prevention Procedures Publishing Randomized Randomized Controlled Trials Recommendation Recruitment Activity Relative (related person)Research Research Project Grants Site Testing Time Very Light Exercise Weight Weight Gain Weight maintenance regimen Woman Work base fast food good diet improved innovation lifestyle intervention meetings nutrition offspring prevent programs psychosocial randomized trial restraint sedentary sound standard care sugar sweetened beverage

项目摘要

Low-intensity lifestyle interventions during pregnancy can prevent excessive gestational weight gain in normal weight women. However, preventing excessive gestational weight gain in obese women has proven more difficult. Intensive interventions involving prescription of specific calorie goals and balanced nutrition have shown the most promise, but, similar to non-pregnant populations, promoting ongoing adherence to caloric prescription remains a significant challenge. Liquid meal-replacement products have been shown to promote adherence to calorie and weight goals in non-pregnant multiethnic populations. Moreover, they have been used during pregnancy as a supplement to improve nutritional adequacy and shown to be safe and to result in improved dietary intal<e. However, no study to date has evaluated this approach as a means to prevent excessive weight gain during pregnancy. The principal aim of this study is to determine whether a multi-component lifestyle intervention that incorporates partial meal replacements during pregnancy can reduce the number of obese women who exceed the lOM recommendations for weight gain during pregnancy. In this two-site randomized trial, 430 obese women, 50% Hispanic, will be randomized within site and ethnicity into either a multi-component lifestyle modification treatment with partial meal replacement program (N=215) or standard care (N=215). Treatment will occur during pregnancy, using standardized intervention procedures from our previous work. All women will be recruited and assessed early in pregnancy (between 10 and 16 weelis), at 30 weeks gestation, and at 6 months, and 12 months postpartum with anthropometric measures obtained at delivery and at 2 months postpartum. We believe this project is significant because it deals with the prevention of excessive gestational weight gain and its associated adverse maternal and offspring health consequences. The study is also innovative; there have been no randomized controlled trials evaluating the effects of a behavioral lifestyle intervention with partial meal replacement program to promote healthy weight gain in multiethnic obese women.

怀孕期间低强度的生活方式干预措施可以防止妊娠体重过度增加正常体重女性。但是，预防肥胖女性的妊娠体重增加过多已被证明更困难。涉及特定卡路里目标和平衡营养的强化干预措施表现出最大的希望，但是，类似于未怀孕的人群热量处方仍然是一个重大挑战。液体粉替代产品已显示为促进对非怀孕的多种族人群中卡路里的依从性和体重目标。而且，他们在怀孕期间已用作改善营养充足性并证明是安全的补充剂并改善饮食饮食。但是，迄今为止尚无研究将这种方法评估为一种手段为了防止怀孕期间的体重增加。这项研究的主要目的是确定是否是否在怀孕期间纳入部分膳食的多组分生活方式干预措施可以减少超过LOM建议以增加体重增加的肥胖女性的数量怀孕。在这项两场随机试验中种族和种族成为多组分的生活方式修改疗法，以部分膳食更换程序（n = 215）或标准护理（n = 215）。使用标准化，将在怀孕期间进行治疗我们以前的工作的干预程序。所有妇女将在早期招募和评估怀孕（10至16个WEELIS），妊娠30周，产后6个月和12个月通过在分娩时和产后2个月获得的人体测量指标。我们相信这个项目是意义重大，因为它涉及预防过度的妊娠体重增加及其相关的不利的母亲和后代健康后果。这项研究也是创新的。没有随机对照试验评估了部分餐的行为生活方式干预的影响替代计划，以促进多种族肥胖女性的健康体重增加。