CRT Lead Placement Planning using MRI

描述（由申请人提供）：使用双心室起搏器的心脏再同步化治疗（CRT）是药物难治性心力衰竭和心室非同步化证据患者的重要治疗选择。然而，使用目前的选择标准和植入技术，30-40%接受CRT的患者对治疗无反应。由于CRT是侵入性的，昂贵的，有显著的相关风险，并且需要终身使用起搏器，因此显然需要更好的方法来优化治疗。多种因素影响患者对CRT的反应，包括不良的选择标准和/或非最佳的设备实施。在实施CRT时，左室起搏导联的位置对决定患者的反应具有重要作用。该项目的总体目标是：1)开发一种基于MRI的方法来规划和定位最近收缩区域的左室起搏导联，2)在一组接受CRT的患者中测试该方法。

DESCRIPTION (provided by applicant): Cardiac resynchronization therapy (CRT) using a bi-ventricular pacemaker is an important treatment option for patients with drug-refractory heart failure and evidence of ventricular dyssynchrony. However, using current selection criteria and implantation techniques, 30-40% of patients undergoing CRT are non-responsive to the treatment. Because CRT is invasive, costly, has significant associated risks, and requires lifelong need of pacing device, there is a clear need for better methods to optimize the treatment. Multiple factors influence patient response to CRT including poor selection criteria and/or non-optimal device implementation. In the implementation of CRT, the position of the left ventricular (LV) pacing lead has a significant role in determining patient response. The overall goals of this project are: 1) to develop an MRI- based methodology to plan and locate the LV pacing lead in the area of latest contraction and 2) test the methodology on a group of patients undergoing CRT.