CRT Lead Placement Planning using MRI

描述（由申请人提供）：使用双心室起搏器的心脏起搏治疗（CRT）是药物难治性心力衰竭和心室不同步证据患者的重要治疗选择。然而，使用当前的选择标准和植入技术，30-40%接受CRT的患者对治疗无反应。由于CRT是侵入性的、昂贵的、具有显著的相关风险，并且需要终身需要起搏装置，因此显然需要更好的方法来优化治疗。多种因素影响患者对CRT的反应，包括不良选择标准和/或非最佳器械实施。在CRT的实施中，左心室（LV）起搏导线的位置在确定患者反应方面具有重要作用。本项目的总体目标是：1）开发一种基于MRI的方法，以计划和定位最近收缩区域中的LV起搏电极导线; 2）在一组接受CRT的患者中测试该方法。

DESCRIPTION (provided by applicant): Cardiac resynchronization therapy (CRT) using a bi-ventricular pacemaker is an important treatment option for patients with drug-refractory heart failure and evidence of ventricular dyssynchrony. However, using current selection criteria and implantation techniques, 30-40% of patients undergoing CRT are non-responsive to the treatment. Because CRT is invasive, costly, has significant associated risks, and requires lifelong need of pacing device, there is a clear need for better methods to optimize the treatment. Multiple factors influence patient response to CRT including poor selection criteria and/or non-optimal device implementation. In the implementation of CRT, the position of the left ventricular (LV) pacing lead has a significant role in determining patient response. The overall goals of this project are: 1) to develop an MRI- based methodology to plan and locate the LV pacing lead in the area of latest contraction and 2) test the methodology on a group of patients undergoing CRT.