CRT Lead Placement Planning using MRI

使用 MRI 进行 CRT 导线放置规划

• 批准号: 8442235
• 负责人: JOHN N OSHINSKI
• 金额: $ 16.97万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8442235
• 关键词: Address; Anatomy; Area; Cardiac; Cicatrix; Computer software; Contracts; Controlled Clinical Trials; Coronary; Data; Development; Devices; Evaluation; Evaluation Methodology; Goals; Heart failure; Image; Implant; International; Lead; Left; Location; Magnetic Resonance Imaging; Maps; Mechanics; Methodology; Methods; Myocardial; Myocardium; Outcome; Pacemakers; Patient Selection; Patients; Performance; Pharmaceutical Preparations; Physiological; Placebo Control; Positioning Attribute; Procedures; Prospective Studies; Refractory; Retrospective Studies; Risk; Role; Selection Criteria; Series; Software Validation; Structure of left gastric vein; Techniques; Testing; Time; Tissues; Venous; Ventricular; Work; base; candidate selection; clinical practice; implantation; improved; research clinical testing; response; software development; success; tool

DESCRIPTION (provided by applicant): Cardiac resynchronization therapy (CRT) using a bi-ventricular pacemaker is an important treatment option for patients with drug-refractory heart failure and evidence of ventricular dyssynchrony. However, using current selection criteria and implantation techniques, 30-40% of patients undergoing CRT are non-responsive to the treatment. Because CRT is invasive, costly, has significant associated risks, and requires lifelong need of pacing device, there is a clear need for better methods to optimize the treatment. Multiple factors influence patient response to CRT including poor selection criteria and/or non-optimal device implementation. In the implementation of CRT, the position of the left ventricular (LV) pacing lead has a significant role in determining patient response. The overall goals of this project are: 1) to develop an MRI- based methodology to plan and locate the LV pacing lead in the area of latest contraction and 2) test the methodology on a group of patients undergoing CRT.

描述(由申请人提供)：使用双心室起搏器的心脏再同步治疗(CRT)是药物难治性心力衰竭患者的重要治疗选择，也是心室不同步的证据。然而，按照目前的选择标准和植入技术，接受CRT治疗的患者中有30%-40%对治疗没有反应。由于CRT具有侵入性，费用昂贵，具有显著的相关风险，并且需要终生需要起搏设备，因此显然需要更好的方法来优化治疗。多种因素影响患者对CRT的反应，包括糟糕的选择标准和/或非最佳的设备实施。在CRT实施中，左室起搏电极的位置对决定患者的反应有重要作用。该项目的总体目标是：1)开发一种基于MRI的方法，以计划和定位最新收缩区域的LV起搏导线；2)在一组接受CRT的患者身上测试该方法。

项目成果

Performance of 3D, navigator echo-gated, contrast-enhanced, magnetic resonance coronary vein imaging in patients undergoing CRT.

• DOI: 10.1007/s10840-014-9934-7
• 发表时间: 2014-11
• 期刊: JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
• 影响因子: 1.8
• 作者: Lam, Adrian;Mora-Vieira, Luis F.;Hoskins, Michael;Lloyd, Michael;Oshinski, John N.
• 通讯作者: Oshinski, John N.

Combined Angiography and Late Gadolinium Enhancement Acquisition to Improve Assessment of Pulmonary Vein Isolation for Atrial Fibrillation.

• DOI: 10.1002/jmri.25771
• 发表时间: 2018-03
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Lam A;Okene E;Parikh A;Zhong X;Tejada T;Hoskins M;Lloyd M;Oshinski JN
• 通讯作者: Oshinski JN