Coronary Fractional Flow Reserve Determined Using MRI and CFD

项目摘要 缺血性冠状动脉疾病(CAD)的主要介入治疗是经皮 介入(PCI)包括血管成形术和血管支架的部署。临床试验表明， 血流储备分数(FFR)，通过取远端压力与狭窄的比率除以 狭窄近端的压力，与使用 仅以血管造影为基础的解剖学标准。尽管有其好处，但有创性测量FFR并不广泛 由于其高昂的费用和程序复杂性而使用。 磁共振成像(MRI)和计算流体动力学(CFD)相结合提供了一种方法 用于非侵入性和无电离辐射的FFR测定。核磁共振可以用于冠状动脉成像， 可以测量冠状动脉流量，是非侵入性的，并且不使用电离辐射。因此，我们的第一个目标是 开发、验证和测试一种基于心脏MRI的方法来确定冠状动脉FFR(FFRMRI)。我们会组队 与西门子医疗保健公司MRI协作部合作开发和测试新的图像采集和 重建方法，并与西门子医疗保健医疗成像技术部合作 发展图像处理方法和显示技术。新的范例将在健康对照中进行测试 并在模型研究中，然后应用于一组冠心病稳定的受试者。

Project Summary The primary interventional treatment for ischemic coronary artery disease (CAD) is percutaneous intervention (PCI) involving angioplasty and deployment of a vascular stent. Clinical trials have shown that fractional flow reserve (FFR), which is assessed by taking the ratio of pressure distal to the stenosis divided by pressure proximal to the stenosis, reduces the number of adverse cardiac events compared to the use of angiographic-based anatomical criteria alone. Despite its benefit, invasive measurement of FFR is not widely used due to its high expense and procedural complexity. Magnetic resonance imaging (MRI) combined with computational fluid dynamics (CFD) offers a method for determining FFR non-invasively and without ionizing radiation. MRI can be used for coronary artery imaging, can measure coronary flow, is non-invasive, and does not use ionizing radiation. Therefore, our first objective is to develop, validate, and test a cardiac MRI-based method to determine coronary FFR (FFRMRI). We will team with the Siemens Healthineers MRI collaboration division to develop and test new image acquisition and reconstruction methodology, and team with the Siemens Healthineers Medical Imaging Technology division to develop image processing methods and display technology. The new paradigm will be tested in healthy controls and in models studies, then applied to a group of subjects with stable CAD.