Coronary Fractional Flow Reserve Determined Using MRI and CFD

使用 MRI 和 CFD 确定冠状动脉血流储备分数

• 批准号: 10579169
• 负责人: JOHN N OSHINSKI
• 金额: $ 32.95万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579169
• 关键词: Anatomy; Angiography; Angioplasty; Arteries; Blood Vessels; Blood flow; Cardiac; Cardiology; Catheterization; Cause of Death; Clinical; Clinical Trials; Collaborations; Complex; Computing Methodologies; Coronary; Coronary Arteriosclerosis; Coronary Artery Ischemia; Coronary Stenosis; Coronary artery; Development; Diagnostic; Distal; Environment; Equation; Etiology; Event; Geometry; Goals; Guidelines; Heart Diseases; Image; Imaging technology; In Vitro; Individual; Industry; Intervention; Ionizing radiation; Joints; Knowledge; Laboratories; Lesion; Liquid substance; Magnetic Resonance Imaging; Mathematics; Measurement; Measures; Medical Imaging; Methodology; Methods; Modeling; Motion; Multi-Institutional Clinical Trial; Non-Invasive Lesion; Outcome; Patient Selection; Patient-Focused Outcomes; Patients; Physiological; Procedures; Protocols documentation; Radiology Specialty; Resources; Rest; Roentgen Rays; Severities; Stenosis; Stents; Stress; Study models; Techniques; Technology; Testing; Time; United States; Universities; biomedical imaging; cardiac magnetic resonance imaging; clinical implementation; computational pipelines; computer science; coronary lesion; experimental study; image processing; improved; in vivo; novel; percutaneous coronary intervention; pressure; reconstruction; simulation; tool

Project Summary The primary interventional treatment for ischemic coronary artery disease (CAD) is percutaneous intervention (PCI) involving angioplasty and deployment of a vascular stent. Clinical trials have shown that fractional flow reserve (FFR), which is assessed by taking the ratio of pressure distal to the stenosis divided by pressure proximal to the stenosis, reduces the number of adverse cardiac events compared to the use of angiographic-based anatomical criteria alone. Despite its benefit, invasive measurement of FFR is not widely used due to its high expense and procedural complexity. Magnetic resonance imaging (MRI) combined with computational fluid dynamics (CFD) offers a method for determining FFR non-invasively and without ionizing radiation. MRI can be used for coronary artery imaging, can measure coronary flow, is non-invasive, and does not use ionizing radiation. Therefore, our first objective is to develop, validate, and test a cardiac MRI-based method to determine coronary FFR (FFRMRI). We will team with the Siemens Healthineers MRI collaboration division to develop and test new image acquisition and reconstruction methodology, and team with the Siemens Healthineers Medical Imaging Technology division to develop image processing methods and display technology. The new paradigm will be tested in healthy controls and in models studies, then applied to a group of subjects with stable CAD.

项目摘要 缺血性冠状动脉疾病（CAD）的主要介入治疗是经皮冠状动脉介入治疗。 介入治疗（PCI）包括血管成形术和血管支架的展开。临床试验表明 血流储备分数（FFR），通过狭窄远端压力除以 狭窄近端的压力，与使用 血管造影的解剖学标准尽管有其益处，但FFR的侵入性测量并不广泛 由于其高成本和程序复杂性而使用。 磁共振成像（MRI）结合计算流体动力学（CFD）提供了一种方法， 用于非侵入性地并且在没有电离辐射的情况下确定FFR。MRI可用于冠状动脉成像， 可以测量冠状动脉流量，是非侵入性的，并且不使用电离辐射。因此，我们的首要目标是 开发、确认和测试基于心脏MRI的方法，以确定冠状动脉FFR（FFRMRI）。我们将团队 与Siemens Healthineers MRI协作部门合作，开发和测试新的图像采集， 重建方法，并与西门子医疗成像技术部门合作， 开发图像处理方法和显示技术。新的范例将在健康对照组中进行测试 在模型研究中，然后应用于一组稳定的CAD受试者。