Development and Control of Pulmonary alveolar Stability

肺泡稳定性的发展和控制

• 批准号: 8411601
• 负责人: Samuel Hawgood
• 金额: $ 174.07万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8411601
• 关键词: Acute; Acute Lung Injury; Address; Adherent Culture; Adult; Allergens; Alveolar; Alveolar Cell; Alveolar Process; Alveolar wall; Alveolus; Animals; Antibodies; Architecture; Attention; Back; Biochemical; Biochemistry; Biological Models; Biological Process; Biology; Breathing; Budgets; Carbon Dioxide; Carcinoembryonic Antigen; Cell Adhesion Molecules; Cell Differentiation process; Cell Lineage; Cell physiology; Cells; Cellular biology; Childhood; Chronic; Chronic lung disease; Collaborations; Communication; Consultations; Cost Savings; Cultured Cells; Cyclic AMP; Data; Data Set; Development; Developmental Biology; Discipline; Disease; Distal; Doctor of Medicine; Doctor of Philosophy; Drug Formulations; Electrons; Epithelial; Epithelial Cells; Equipment; Equipment and Supplies; Exposure to; Faculty; Familiarity; Fetal Lung; Fibrosis; Funding; Gases; Gene Expression; Gene Targeting; Genes; Genetic; Genetic Techniques; Genome; Genomics; Glucocorticoids; Goals; Growth; Growth Factor; Health; Homeostasis; Hormones; Host Defense; Host Defense Mechanism; Housing; Human; Human Resources; Image Analysis; Immune; Immune system; Immunity; Individual; Infection; Infectious Agent; Inflammation; Inflammatory; Injury; Institutes; Intestinal Neoplasms; Intracellular Signaling Proteins; Investigation; Joints; Laboratories; Lead; Life; Light; Liquid substance; Lung; Lung diseases; Maintenance; Maps; Measurement; Membrane; Metabolism; Methods; Microscopy; Molecular; Molecular Biology; Molecular Structure; Molecular and Cellular Biology; Mucous Membrane; Mus; Natural regeneration; Oxygen; Peer Review; Pennsylvania; Personnel Management; Phenotype; Physiological; Physiology; Plastics; Positioning Attribute; Prevention; Principal Investigator; Process; Production; Protein Family; Proteins; Publications; Pulmonary Gas Exchange; Pulmonary Surfactant-Associated Protein D; Pulmonary Surfactants; Quality Control; Rattus; Recording of previous events; Regulation; Research; Research Personnel; Research Project Grants; Resources; Respiratory System; Respiratory Tract Infections; Respiratory tract structure; Rodent; Role; Schools; Science; Series; Serum-Free Culture Media; Services; Specialist; Stable Populations; Stimulus; Stress; Structure; Structure of parenchyma of lung; Structure of respiratory epithelium; Surface; System; Techniques; Tenascin; Testing; Time; Tissues; Transcriptional Regulation; Transgenes; Transgenic Mice; Transgenic Organisms; Tumor Markers; Type II Epithelial Receptor Cell; Undifferentiated; Universities; Ursidae Family; Work; alveolar epithelium; base; cost; cost effective; disorder control; editorial; environmental change; environmental particulate; experience; fetal; genetic manipulation; hormone regulation; implementation research; improved; in vitro Model; infancy; innate immune function; interest; lung development; lung injury; lung repair; meetings; member; microorganism; mouse model; multidisciplinary; novel; novel strategies; pediatric department; pollutant; programs; protein structure function; repaired; research study; respiratory; respiratory distress syndrome; response; surfactant

DESCRIPTION (provided by applicant): This application proposes to continue multidisciplinary studies of development, control and disorders of the pulmonary parenchyma. The objectives of the proposal are to examine some of the mechanisms involved in the formation and stabilization of the pulmonary parenchyma during development and post-natal life, and in states of health and disease. By stabilization we mean the integrated physiochemical and biological processes that develop and maintain alveolar architecture in an optimal state for pulmonary gas exchange. As in our past studies we emphasize investigations of alveolar epithelial development, functions of the lung surfactant system, and alveolar disease processes leading to infection and inflammation. The broad goals of the three inter-related projects proposed are: Project 1: Structure and function of surfactant proteins. To study the relationship between the structure of the surfactant proteins, specifically SP-D, and their functions in regulating the immune milieu of the alveolus. Project 2: Expression and role of CEACAM6 in the alveolus. To investigate the role of carcinoembryonic antigen-6 in alveolar innate immune defense, surfactant function, and epithelial response to acute lung injury. Project 3: Alveolar epithelial cell fates: mapping and regulation. To study alveolar epithelial cell lineages during development and regeneration and to elucidate novel regulatory molecules important to the process of alveolar epithelial differentiation. The overall purpose of these studies is to deepen our understanding of the processes underlying lung parenchymal stability and to contribute to new concepts and treatments for lung diseases associated with disorders of alveolar stability, growth, maturation, and repair after injury.

描述（由申请人提供）：本申请建议继续对肺实质的发育、控制和疾病进行多学科研究。该提案的目的是研究发育和产后生活以及健康和疾病状态下肺实质形成和稳定的一些机制。通过稳定，我们指的是综合的生理化学和生物过程，其发展和维持肺泡结构处于肺部气体交换的最佳状态。与我们过去的研究一样，我们强调对肺泡上皮发育、肺表面活性物质系统的功能以及导致感染和炎症的肺泡疾病过程的研究。 拟议的三个相互关联的项目的总体目标是： 项目1：表面活性蛋白的结构和功能。研究表面活性蛋白（特别是 SP-D）的结构与其调节肺泡免疫环境的功能之间的关系。 项目 2：CEACAM6 在肺泡中的表达和作用。探讨癌胚抗原 6 在肺泡先天免疫防御、表面活性剂功能和急性肺损伤上皮反应中的作用。 项目 3：肺泡上皮细胞命运：绘图和调节。研究发育和再生过程中的肺泡上皮细胞谱系，并阐明对肺泡上皮分化过程重要的新型调节分子。 这些研究的总体目的是加深我们对肺实质稳定性基础过程的理解，并为与肺泡稳定性、生长、成熟和损伤后修复相关的肺部疾病提供新的概念和治疗方法。