Insulin-like growth factor binding protein-2 is a crucial activator of aggressive behaviour in cancer cells

胰岛素样生长因子结合蛋白2是癌细胞侵袭行为的关键激活剂

• 批准号: nhmrc : 1008062
• 负责人: A/Pr John Price
• 金额: $ 40.87万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/insulin-like-growth-cancer-cells/109275
• 关键词: Insulin; like; growth; factor; binding

The insulin-like growth factor (IGF) system, required for normal development and adult life, is often altered in many diseases including cancer. Key regulators of the IGF system are the IGF binding protein (IGFBP) of which IGFBP-2 is the 2nd most abundant. IGFBP-2 may enhance or inhibit the IGFs, but the mechanisms are not clear. This proposal aims to dissect IGFBP-2 action with the ultimate goal to provide knowledge for the development of targeted therapeutic modulators of IGFBP-2 activity.

正常发育和成年生活所需的胰岛素样生长因子（IGF）系统在包括癌症在内的许多疾病中经常发生改变。IGF系统的关键调节因子是IGF结合蛋白（IGFBP），其中IGFBP-2是第二丰富的。IGFBP-2可能增强或抑制IGFs的表达，但其机制尚不清楚。该提案旨在剖析IGFBP-2的作用，最终目标是为开发IGFBP-2活性的靶向治疗调节剂提供知识。