Insulin-like growth factor binding protein-2 is a crucial activator of aggressive behaviour in cancer cells

胰岛素样生长因子(IGF)系统是正常发育和成人生活所必需的，在包括癌症在内的许多疾病中经常发生变化。胰岛素样生长因子系统的关键调节因子是胰岛素样生长因子结合蛋白(IGFBP)，其中IGFBP-2含量居第二位。IGFBP-2可促进或抑制IGFS，但其作用机制尚不清楚。这项提案旨在剖析IGFBP-2的作用，最终目的是为开发IGFBP-2活性的靶向治疗调节剂提供知识。

The insulin-like growth factor (IGF) system, required for normal development and adult life, is often altered in many diseases including cancer. Key regulators of the IGF system are the IGF binding protein (IGFBP) of which IGFBP-2 is the 2nd most abundant. IGFBP-2 may enhance or inhibit the IGFs, but the mechanisms are not clear. This proposal aims to dissect IGFBP-2 action with the ultimate goal to provide knowledge for the development of targeted therapeutic modulators of IGFBP-2 activity.