Determining the influences of cell stress and heat shock factor-1 action in osteoclast formation and pathological bone loss.

确定细胞应激和热休克因子 1 作用对破骨细胞形成和病理性骨质流失的影响。

• 批准号: nhmrc : 1057706
• 负责人: A/Pr John Price
• 金额: $ 43.83万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-influences-cell-bone-loss/454623
• 关键词: Determining; influences; cell; stress; heat

Cancer and rheumatoid arthritis cause painful bone destruction. This occurs due to increased numbers of bone destroying cells called osteoclasts. We found stress responses in bone cells can increase osteoclast numbers by activating proteins inside the bone cells that encourage osteoclasts to form. We will thus study whether cell stress blocking drugs might stop bone loss. As arthritis and cancer both cause stress responses, this work could identify a new way that such diseases affect bone.

癌症和类风湿性关节炎会导致痛苦的骨质破坏。这是由于称为破骨细胞的骨质破坏细胞数量增加而发生的。我们发现骨细胞中的应激反应可以通过激活骨细胞内促进破骨细胞形成的蛋白质来增加破骨细胞的数量。因此，我们将研究细胞应激阻断药物是否可以阻止骨质流失。由于关节炎和癌症都会引起应激反应，这项工作可以确定此类疾病影响骨骼的新方式。