Heat Shock Transcription Factors in Bone Remodeling and Disease

骨重塑和疾病中的热休克转录因子

• 批准号: nhmrc : 606549
• 负责人: A/Pr John Price
• 金额: $ 32.03万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/heat-shock-transcription-remodeling-disease/77307
• 关键词: Heat; Shock; Transcription; Factors; Bone

The denisity of bone is finely balaned and required for a healthy lifestyle. During times of disease, damage or drug treatments the bone can be compromised, often decreasing in density and becoming fragile. This often leads to fractures, pain and a poor quality of life. This proposal seeks to investigate whether stress insults to bones plays a role in the loss of bone. This will provide new insights into bone loss during disease and lead to novel treatment strategies.

骨骼的密度是平衡的，是健康生活方式所必需的。在疾病、损伤或药物治疗期间，骨骼可能会受到损害，通常密度降低并变得脆弱。这通常会导致骨折、疼痛和生活质量低下。该提案旨在调查对骨骼的应力损伤是否在骨丢失中起作用。这将为疾病期间的骨丢失提供新的见解，并导致新的治疗策略。