FUNCTIONAL ANALYSIS OF IGF-BINDING PROTEIN-2 MOLECULAR INTERACTIONS IN EARLY DEVELOPMENT AND DISEASE

IGF 结合蛋白 2 分子相互作用在早期发育和疾病中的功能分析

• 批准号: nhmrc : 436955
• 负责人: A/Pr John Price
• 金额: $ 36.76万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-analysis-igf-development-disease/77231
• 关键词: FUNCTIONAL; ANALYSIS; IGF; BINDING; PROTEIN

Early development involves complex regulation of cell and organ growth. Cell migration and invasion are critical components of epithelial-mesenchymal transition (EMT) essential for early developmental, as well as injury repair and cancer. Common to these events is a highly expressed protein, insulin-like growth factor binding protein-2 (IGFBP-2), which appears to play a critical role in regulating the processes of cell migration and invasion. The underlying mechanisms of cellular regulation by IGFBP-2 are major focus of this proposal, which brings together four major groups focussed on early development, neural injury repair, and cancer biology. We will use a range of in vitro and in vivo approaches to determine the underlying mechanisms of action of this critical protein. This project has the potential to point to novel therapeutic modalities in development, repair and cancer.

早期发育涉及细胞和器官生长的复杂调节。细胞迁移和侵袭是上皮间质转化 (EMT) 的关键组成部分，对于早期发育、损伤修复和癌症至关重要。这些事件的共同点是一种高表达的蛋白质——胰岛素样生长因子结合蛋白-2 (IGFBP-2)，它似乎在调节细胞迁移和侵袭过程中发挥着关键作用。 IGFBP-2 细胞调节的基本机制是该提案的主要焦点，该提案汇集了专注于早期发育、神经损伤修复和癌症生物学的四个主要小组。我们将使用一系列体外和体内方法来确定这种关键蛋白质的潜在作用机制。该项目有可能为发育、修复和癌症领域指明新的治疗方式。