Project 1

项目1 我们的新提案将研究肯尼亚妇女的纵向队列，平衡人类免疫缺陷病毒（HIV）感染（约50% HIV感染和50%非HIV感染），旨在捕获有关致癌人乳头瘤病毒（HPV）感染在成年早期和宫颈癌在成年后期之间的时间段的新信息。有必要研究影响HPV感染的社会文化因素以及感染艾滋病毒的妇女中HPV相关疾病的发病率和严重程度。 本申请的核心目的是更好地了解感染艾滋病毒的肯尼亚妇女致癌HPV感染的自然史，以及与致癌HPV感染进展为临床疾病（包括宫颈癌）相关的潜在可改变（和不可改变）因素。

Project 1 Our novel proposal will study a longitudinal cohort of Kenyan women, balanced for human immunodeficiency virus (HIV) infection (approximately 50% HIV-infected and 50% non-HIV-infected), and is designed to capture new information about the largely unstudied time period between oncogenic human papillomavirus (HPV) infection in early adulthood and cervical cancer in later adult years. There is a need to study the sociocultural factors that affect HPV infections and the incidence and severity of HPV-related disease in HIV-infected women. The core objective of this application is to better understand the natural history of oncogenic HPV infections in HIV-infected Kenyan women, and the potentially modifiable (and non-modifiable) factors that are associated with progression of oncogenic HPV infection to clinical disease, including cervical cancer.