Project 1-Preventing cervical cancer in HIV-infected women
项目1-艾滋病毒感染妇女预防宫颈癌
基本信息
- 批准号:10084053
- 负责人:
- 金额:$ 13.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-07 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS related cancerAIDS/HIV problemAcetic AcidsAflatoxinsAfricaAfrica South of the SaharaBiopsyCD4 Lymphocyte CountCaringCervical Cancer ScreeningCervical Intraepithelial NeoplasiaCervical dysplasiaClinicalCost Effectiveness AnalysisCountryDNADataDatabasesDetectionExposure toHIVHPV-High RiskHuman PapillomavirusHuman papilloma virus infectionImmune systemImmunosuppressionImmunosuppressive AgentsImpairmentIncidenceInfrastructureKenyaLiteratureMalignant NeoplasmsMalignant neoplasm of cervix uteriMedicalMethodsMycotoxinsNatural HistoryOncogenicOutcomePlasmaPoliciesPrevalenceResearchRiskRisk FactorsScreening procedureSwabTestingTrainingUgandaVaginaViral load measurementVirusVisualWomanantiretroviral therapycarcinogenicitycofactorcostdesignexperiencehigh riskimprovedinsightpreventprogramsreconstitutionscreening
项目摘要
Abstract
In contrast to other HIV-associated cancers, the incidence of cervical cancer has not declined in the era of
antiretroviral therapy (ART), and is the most common cancer among Kenyan and Ugandan women. These
countries each have high HIV prevalence, which greatly accelerates the progression of cervical cancer, even in
women receiving ART and achieving “reconstituted” immune systems. Better methods of screening are
needed, and we need to understand cofactors related to HPV infection, the virus that causes cervical cancer.
The long-term objective of our project is to help eradicate cervical cancer in HIV-infected Kenyan and Ugandan
women. We will test our approach in a study of HIV-infected women. First, we will evaluate HR-HPV DNA
testing of self-collected vaginal swabs combined with VIA in detecting biopsy-proven cervical intraepithelial
neoplasia grades 2, 3, or worse (CIN 2/3+) in HIV-infected women living in Kenya or Uganda. We
hypothesized that detection of biopsy-proven CIN 2/3+ is higher among HIV-infected women with both HR-
HPV DNA positivity and VIA abnormality compared to those with only one or neither of these tests positive.
Second, we will determine if aflatoxin, a carcinogenic and immunosuppressive compound found in
contaminated corn, is a risk factor for oncogenic HPV detection and cervical cancer among HIV-infected
Kenyan and Ugandan women. We hypothesize that regardless of HIV-status, aflatoxin is a risk factor for HR-
HPV detection, HR-HPV persistence, and biopsy-proven CIN 2/3+, that the impact of aflatoxin on HR-HPV
detection, HR-HPV persistence, and biopsy-proven CIN 2/3+ will be significantly greater in HIV-infected
women than in HIV-uninfected women, and that the immunosuppressive effects of aflatoxin impair the host’s
ability to control HIV in spite of ART use. Accomplishment of our aims will help improve care for all women in
Kenya and Uganda, and help in the battle against cervical cancer in HIV-infected women.
摘要
项目成果
期刊论文数量(0)
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会议论文数量(0)
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DARRON R BROWN其他文献
DARRON R BROWN的其他文献
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{{ truncateString('DARRON R BROWN', 18)}}的其他基金
Project 1-Preventing cervical cancer in HIV-infected women
项目1-艾滋病毒感染妇女预防宫颈癌
- 批准号:
10477367 - 财政年份:2020
- 资助金额:
$ 13.09万 - 项目类别:
Project 1-Preventing cervical cancer in HIV-infected women
项目1-艾滋病毒感染妇女预防宫颈癌
- 批准号:
10256042 - 财政年份:2020
- 资助金额:
$ 13.09万 - 项目类别:
The East Africa Consortium for HPV and Cervical Cancer in Women living with HIV/AIDS
东非艾滋病毒/艾滋病女性 HPV 和宫颈癌联盟
- 批准号:
10256037 - 财政年份:2020
- 资助金额:
$ 13.09万 - 项目类别:
The East Africa Consortium for HPV and Cervical Cancer in Women living with HIV/AIDS
东非艾滋病毒/艾滋病女性 HPV 和宫颈癌联盟
- 批准号:
10084048 - 财政年份:2020
- 资助金额:
$ 13.09万 - 项目类别:
The East Africa Consortium for HPV and Cervical Cancer in Women living with HIV/AIDS
东非艾滋病毒/艾滋病女性 HPV 和宫颈癌联盟
- 批准号:
10477359 - 财政年份:2020
- 资助金额:
$ 13.09万 - 项目类别:
AMPATH-Oncology Institute: HPV and Cervical Cancer in Kenyan Women with HIV/AIDS
AMPATH-肿瘤学研究所:感染艾滋病毒/艾滋病的肯尼亚妇女中的 HPV 和宫颈癌
- 批准号:
8794571 - 财政年份:2014
- 资助金额:
$ 13.09万 - 项目类别:
AMPATH-Oncology Institute: HPV and Cervical Cancer in Kenyan Women with HIV/AIDS
AMPATH-肿瘤学研究所:感染艾滋病毒/艾滋病的肯尼亚妇女中的 HPV 和宫颈癌
- 批准号:
9342704 - 财政年份:2014
- 资助金额:
$ 13.09万 - 项目类别: