The East Africa Consortium for HPV and Cervical Cancer in Women living with HIV/AIDS
东非艾滋病毒/艾滋病女性 HPV 和宫颈癌联盟
基本信息
- 批准号:10084048
- 负责人:
- 金额:$ 99.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-07 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS related cancerAIDS/HIV problemAcetic AcidsAflatoxinsAfricaAfrica South of the SaharaAfricanBiologicalBiological FactorsBiological MarkersBiometryCervicalCervical Cancer ScreeningCervical Intraepithelial NeoplasiaCervical dysplasiaCervix NeoplasmsClinicalCommunicable DiseasesDataDevelopmentDiagnosisEnvironmental Risk FactorEpidemiologyGoalsHIVHPV-High RiskHuman PapillomavirusHuman papilloma virus infectionIncidenceIngestionInstitutesKenyaKnowledgeLesionLocal TherapyMalignant NeoplasmsMalignant neoplasm of cervix uteriMentorsNatural HistoryNursesOutcomePhysiciansPilot ProjectsPrevalenceResearchResearch InfrastructureResearch PersonnelResource SharingScientistTestingTrainingTraining ProgramsTranslational ResearchTriageUgandaViralVisualWomanantiretroviral therapycarcinogenesiscareercervical carcinogenesiscofactordata managementdesigninternational partnershiploop electrosurgical excision procedurelow and middle-income countriespremalignantpreventprogramsscreeningviral DNA
项目摘要
Overall Abstract
Sub-Saharan Africa contains 70% of the world’s diagnosed cases of HIV/AIDS, with both Uganda and Kenya at
its epicenter (12% and 7% prevalence, respectively). Within East Africa, cervical cancer remains one of the most
common malignancies in women. HIV is a contributing factor for cervical carcinogenesis with HIV-infected
women having a greater incidence and persistence of human papilloma virus (HPV) infections, cervical cancer,
and precancerous cervical lesions. In contrast to other HIV-associated cancers, the incidence of cervical cancer
has not declined in the era of antiretroviral therapy.
The core objective of this application is to better elucidate the natural history of HPV infection and cervical cancer
in HIV-infected women, including the cofactors involved in carcinogenesis, the persistence and progression of
cervical intraepithelial neoplasia (CIN) after LEEP, and to identify new viral and cellular biomarkers that will assist
in screening, triage and treatment.
Our central hypothesis is that the incidence, persistence, and spectrum of high risk (HR) HPV are substantially
greater in HIV-infected East African women, and that this explains the higher incidence of cervical neoplasia.
We further hypothesize that these and other modifiable factors, such as aflatoxin ingestion, disproportionately
and adversely influence outcomes of local therapies such as Loop Electrosurgical Excision Procedure (LEEP)
in HIV-infected women.
The specific aims for the East Africa Consortium for HPV and Cervical Cancer (EACHC) in Women Living with
HIV/AIDS are:
Specific Aim 1. To establish a sustainable research infrastructure for an international partnership to conduct
impactful research in HPV and cervical cancer in women living with HIV/AIDS
Specific Aim 2. To design and execute three integrated projects that advance the knowledge of the
environmental and biologic factors leading to cervical cancer in East Africa:
Project 1- Preventing cervical cancer in HIV-infected women
Project 2- Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and
immunohistochemical study
Project 3- Determining biological and viral factors associated with clinical progression of cervical dysplasia
in HIV-infected women
Specific Aim 3. To increase the research workforce capacity in East Africa through mentoring, training programs
and targeted pilot projects
总体摘要
撒哈拉以南非洲地区占世界艾滋病毒/艾滋病确诊病例的 70%,其中乌干达和肯尼亚均处于这一水平。
其震中(患病率分别为 12% 和 7%)。在东非,宫颈癌仍然是最常见的癌症之一
女性常见的恶性肿瘤。 HIV是HIV感染者宫颈癌发生的一个促成因素
女性人乳头状瘤病毒(HPV)感染、宫颈癌、
和宫颈癌前病变。与其他与艾滋病毒相关的癌症相比,宫颈癌的发病率
在抗逆转录病毒治疗时代并未衰落。
该应用的核心目标是更好地阐明HPV感染和宫颈癌的自然史
在感染艾滋病毒的女性中,包括参与致癌作用的辅助因子、癌症的持续存在和进展
LEEP 后的宫颈上皮内瘤变 (CIN),并确定新的病毒和细胞生物标志物,以帮助
在筛查、分诊和治疗方面。
我们的中心假设是,高危 (HR) HPV 的发病率、持续性和谱系与
感染艾滋病毒的东非妇女的比例更高,这解释了宫颈肿瘤发病率较高的原因。
我们进一步假设这些和其他可改变的因素,例如黄曲霉毒素的摄入,不成比例地
并对局部治疗的结果产生不利影响,例如环形电外科切除手术(LEEP)
感染艾滋病毒的女性。
东非女性 HPV 和宫颈癌联盟 (EACHC) 的具体目标
艾滋病毒/艾滋病是:
具体目标 1. 建立可持续的研究基础设施,以便国际伙伴关系开展
对感染艾滋病毒/艾滋病的女性中的 HPV 和宫颈癌进行有影响力的研究
具体目标 2. 设计和执行三个综合项目,以提高人们的知识
导致东非宫颈癌的环境和生物因素:
项目1-预防艾滋病毒感染妇女的宫颈癌
项目 2 - 了解 LEEP 后 HIV 感染女性中的 CIN2+:流行病学和
免疫组织化学研究
项目 3 - 确定与宫颈发育不良临床进展相关的生物和病毒因素
感染艾滋病毒的女性
具体目标 3. 通过指导、培训计划提高东非研究人员的能力
和有针对性的试点项目
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DARRON R BROWN其他文献
DARRON R BROWN的其他文献
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{{ truncateString('DARRON R BROWN', 18)}}的其他基金
Project 1-Preventing cervical cancer in HIV-infected women
项目1-艾滋病毒感染妇女预防宫颈癌
- 批准号:
10477367 - 财政年份:2020
- 资助金额:
$ 99.53万 - 项目类别:
Project 1-Preventing cervical cancer in HIV-infected women
项目1-艾滋病毒感染妇女预防宫颈癌
- 批准号:
10256042 - 财政年份:2020
- 资助金额:
$ 99.53万 - 项目类别:
The East Africa Consortium for HPV and Cervical Cancer in Women living with HIV/AIDS
东非艾滋病毒/艾滋病女性 HPV 和宫颈癌联盟
- 批准号:
10256037 - 财政年份:2020
- 资助金额:
$ 99.53万 - 项目类别:
The East Africa Consortium for HPV and Cervical Cancer in Women living with HIV/AIDS
东非艾滋病毒/艾滋病女性 HPV 和宫颈癌联盟
- 批准号:
10477359 - 财政年份:2020
- 资助金额:
$ 99.53万 - 项目类别:
Project 1-Preventing cervical cancer in HIV-infected women
项目1-艾滋病毒感染妇女预防宫颈癌
- 批准号:
10084053 - 财政年份:2020
- 资助金额:
$ 99.53万 - 项目类别:
AMPATH-Oncology Institute: HPV and Cervical Cancer in Kenyan Women with HIV/AIDS
AMPATH-肿瘤学研究所:感染艾滋病毒/艾滋病的肯尼亚妇女中的 HPV 和宫颈癌
- 批准号:
8794571 - 财政年份:2014
- 资助金额:
$ 99.53万 - 项目类别:
AMPATH-Oncology Institute: HPV and Cervical Cancer in Kenyan Women with HIV/AIDS
AMPATH-肿瘤学研究所:感染艾滋病毒/艾滋病的肯尼亚妇女中的 HPV 和宫颈癌
- 批准号:
9342704 - 财政年份:2014
- 资助金额:
$ 99.53万 - 项目类别:














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