Translational Biology Core

翻译生物学核心 转化生物学核心项目的目标是为AMPATH肿瘤研究所的项目1（“预测肯尼亚艾滋病毒阳性妇女中致癌性人乳头瘤病毒和宫颈发育不良持续存在的可变因素”）和项目2（“肯尼亚西部艾滋病毒和艾滋病毒阳性妇女中冷冻疗法/LEEP的结果”）提供支持：肯尼亚艾滋病毒/艾滋病妇女中的人乳头瘤病毒和宫颈癌。这种支持将包括样本的储存，样本在检测地点之间的运输，STI检测，HPV基因分型，并提供一个空间，让年轻的医生科学家，研究生和技术人员可以扩大他们的实验室技能。将在两个研究中心之间进行分工：1）与肯尼亚埃尔多雷特的莫伊大学医学院（MUSOM）合作的提供医疗保健的学术模型（AMPATH）和2）肯尼亚基苏穆的肯尼亚医学研究所（KEMRI）。这两个实验室都具有独特的能力，将被整合，以提供完成本提案中概述的这些项目所需的测试。TBC的另一个作用是与指导核心（MC）和生物统计核心和数据管理（BC）互动。TBC将生成由BC进一步分析的数据，并将定期与他们合作。TBC还将为将由MC指导的教学学员提供空间。

Translational Biology Core The objective of the Translational Biology Core (TBC) is to provide support to Projects 1 ("Modifiable factors predicting persistence of oncogenic HPV and cervical dysplasia in HIV-positive Kenyan women") and Project 2 ("Results of Cryotherapy/LEEP among HIV- and HIV+ Women in Western Kenya") of the AMPATH-Oncology Institute: HPV and Cervical Cancer in Kenyan Women with HIV/AIDS. This support will include storage of samples, transportation of samples between testing sites, STI testing, HPV genotyping, and providing a space in which young physician scientists, graduate students, and technicians can expand their laboratory repertoire. The division of labor will occur between two sites: 1) Academic Model Providing Access to Healthcare (AMPATH) in partnership with the Moi University School of Medicine (MUSOM) in Eldoret, Kenya and 2) Kenya Medical Research Institute (KEMRI) in Kisumu, Kenya. Both laboratories have unique capabilities that will be integrated to provide the testing necessary to complete these projects outlined in this proposal. The other role of the TBC is to interact with the Mentoring Core (MC) and the Biostatistics Core and Data Management (BC). The TBC will be generating the data that will be further analyzed by the BC and will regularly collaborate with them. The TBC will also provide the space for teaching trainees that will be guided by the MC.