Translational Biology Core

翻译生物学核心 翻译生物学核心(TBC)的目标是支持AMPATH-肿瘤学研究所的项目1(“预测艾滋病毒阳性肯尼亚妇女中致癌HPV和宫颈发育不良持续存在的可修改因素”)和项目2(“在肯尼亚西部艾滋病毒携带者和艾滋病毒+妇女中冷冻治疗/LEEP的结果”)：肯尼亚艾滋病毒/艾滋病妇女中的HPV和宫颈癌。这项支持将包括样本存储、样本在检测地点之间的运输、STI测试、HPV基因分型，并为年轻的内科科学家、研究生和技术人员提供一个空间，让他们可以扩大他们的实验室技能。分工将在两个地点进行：1)与肯尼亚埃尔多雷特的莫伊大学医学院(MUSOM)合作的提供医疗服务的学术模式(AMPATH)，以及2)肯尼亚基苏木的肯尼亚医学研究所(KEMRI)。这两个实验室都有独特的能力，将进行整合，以提供完成本提案中概述的这些项目所需的测试。TBC的另一个角色是与指导核心(MC)和生物统计核心和数据管理(BC)互动。TBC将生成将由BC进一步分析的数据，并将定期与他们合作。TBC还将为由MC指导的受训者提供教学空间。

Translational Biology Core The objective of the Translational Biology Core (TBC) is to provide support to Projects 1 ("Modifiable factors predicting persistence of oncogenic HPV and cervical dysplasia in HIV-positive Kenyan women") and Project 2 ("Results of Cryotherapy/LEEP among HIV- and HIV+ Women in Western Kenya") of the AMPATH-Oncology Institute: HPV and Cervical Cancer in Kenyan Women with HIV/AIDS. This support will include storage of samples, transportation of samples between testing sites, STI testing, HPV genotyping, and providing a space in which young physician scientists, graduate students, and technicians can expand their laboratory repertoire. The division of labor will occur between two sites: 1) Academic Model Providing Access to Healthcare (AMPATH) in partnership with the Moi University School of Medicine (MUSOM) in Eldoret, Kenya and 2) Kenya Medical Research Institute (KEMRI) in Kisumu, Kenya. Both laboratories have unique capabilities that will be integrated to provide the testing necessary to complete these projects outlined in this proposal. The other role of the TBC is to interact with the Mentoring Core (MC) and the Biostatistics Core and Data Management (BC). The TBC will be generating the data that will be further analyzed by the BC and will regularly collaborate with them. The TBC will also provide the space for teaching trainees that will be guided by the MC.