Translational Biology Core

转化生物学核心

• 批准号: 8935196
• 负责人: DARRON R BROWN
• 金额: $ 9.55万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-19 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8935196
• 关键词: Acquired Immunodeficiency Syndrome; Africa South of the Sahara; American; Biology; Biopsy; Biostatistics Core; Cancerous; Cervical; Cervical Intraepithelial Neoplasia; Cervical dysplasia; Chlamydia trachomatis; Cold Therapy; Data; Development; Diagnosis; Educational process of instructing; Epidemiology; Future; Genotype; HIV; Head and Neck Cancer; Health Services Accessibility; Human Papillomavirus; Human papilloma virus infection; Incidence; Indiana; Infection; Institutes; Kenya; Knowledge; Laboratories; Life; Loop electrosurgical excision procedure; Malignant Neoplasms; Malignant Vaginal Neoplasm; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of vulva; Medical Research; Mentors; Modeling; Molecular Epidemiology; Neisseria gonorrhoeae; Oncogenic; Physicians; Prevention; Principal Investigator; Process; Research Institute; Research Personnel; Risk; Role; Sampling; Scientist; Sexually Transmitted Diseases; Site; Students; Swab; Testing; Transportation; Universities; Vagina; Woman; biobank; burden of illness; data management; experience; graduate student; medical schools; oncology

Translational Biology Core The objective of the Translational Biology Core (TBC) is to provide support to Projects 1 ("Modifiable factors predicting persistence of oncogenic HPV and cervical dysplasia in HIV-positive Kenyan women") and Project 2 ("Results of Cryotherapy/LEEP among HIV- and HIV+ Women in Western Kenya") of the AMPATH-Oncology Institute: HPV and Cervical Cancer in Kenyan Women with HIV/AIDS. This support will include storage of samples, transportation of samples between testing sites, STI testing, HPV genotyping, and providing a space in which young physician scientists, graduate students, and technicians can expand their laboratory repertoire. The division of labor will occur between two sites: 1) Academic Model Providing Access to Healthcare (AMPATH) in partnership with the Moi University School of Medicine (MUSOM) in Eldoret, Kenya and 2) Kenya Medical Research Institute (KEMRI) in Kisumu, Kenya. Both laboratories have unique capabilities that will be integrated to provide the testing necessary to complete these projects outlined in this proposal. The other role of the TBC is to interact with the Mentoring Core (MC) and the Biostatistics Core and Data Management (BC). The TBC will be generating the data that will be further analyzed by the BC and will regularly collaborate with them. The TBC will also provide the space for teaching trainees that will be guided by the MC.

转化生物学核心 转化生物学核心 (TBC) 的目标是为 AMPATH 肿瘤研究所的项目 1（“预测 HIV 阳性肯尼亚妇女持续存在致癌 HPV 和宫颈发育不良的可修改因素”）和项目 2（“肯尼亚西部 HIV 感染和 HIV+ 妇女冷冻治疗/LEEP 的结果”）提供支持：患有 HPV 和宫颈癌的肯尼亚妇女 艾滋病毒/艾滋病。这种支持将包括样本存储、检测地点之间的样本运输、STI 检测、HPV 基因分型，以及为年轻医师科学家、研究生和技术人员提供一个可以扩展其实验室能力的空间。分工将在两个地点进行：1) 与肯尼亚埃尔多雷特的莫伊大学医学院 (MUSOM) 合作提供医疗保健的学术模型 (AMPATH) 和 2) 位于肯尼亚基苏木的肯尼亚医学研究所 (KEMRI)。两个实验室都拥有独特的能力，将整合这些能力来提供完成本提案中概述的这些项目所需的测试。 TBC 的另一个作用是与指导核心 (MC) 以及生物统计核心和数据管理 (BC) 互动。 TBC 将生成数据，BC 将进一步分析这些数据，并定期与他们合作。 TBC 还将为受训人员提供由 MC 指导的教学空间。