Translational Research Training Program in Environmental Health Sciences

环境健康科学转化研究培训计划

• 批准号: 8692786
• 负责人: Trevor M Penning
• 金额: $ 38.34万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8692786
• 关键词: Environmental Health; Research Training; Training Programs; Translational Research

DESCRIPTION (provided by applicant) This is a resubmission of an application for a new Institutional Training Grant (T32) to support a Translational Research Training Program in Environmental Health Sciences for pre- and post- doctoral fellows at the University of Pennsylvania. The home for the Training Program will be the Center of Excellence in Environmental Toxicology (CEET) which is a P30 Environmental Health Sciences Core Center funded by NIEHS. The CEET is a Translational Environmental Health Sciences Center with a focus on major societal disease that affects the Philadelphia area: including but not limited to lung and airway disease, and reproductive, endocrinology, and developmental disorders (including the developmental basis of adult disease). Additionally, there is a strong emphasis on disease mechanism involving oxidative stress and gene-environment interactions. Pre-doctoral fellows, 2 per year, will be supported for three years bringing the steady state to 6 pre-doctoral fellows. Postdoctoral fellows preferably one Ph.D. and one M.D. will be appointed per year and will be supported for two years bringing the steady state to 4 postdoctoral fellows. Pre-doctoral fellows will be recruited to the investigators' umbrella program Biomedical Graduate Studies will be eligible to apply to the Certificate Program in Environmental Health Sciences which is a unique 2 year curriculum consisting of didactic course work and three rotations, one of which must be either a community-based research or population-based research rotation so that hands on training in environmental/molecular epidemiology is provided. Pre-doctoral fellows will be appointed to the Training Grant (TG) after completion of the first year of the Certificate Program. The training Program is distinct from the Certificate Program. All pre-doctoral fellows must take the Certificate Program but not all students in the Certificate Program will be supported by the Training Program. Those supported by the Training Program are expected to conduct thesis work in environmental health science that will be dual mentored by a basic and clinical scientist preceptor and will take additional course work in translational research training. Basic scientist postdoctoral fellows wishing to pursue clinical research on a disease of environmental etiology and clinician scientists wishing to pursue basic research on molecular and cellular mechanisms that lead to such disease will be appointed for up to two years. They will also be dual mentored. Postdoctoral fellows will be required to take at least four courses available to the Training Program pre-doctoral fellows to supplement their knowledge base. Postdoctoral fellows will also receive additional mentoring through the Career Development Core of the CEET. This Training Program provides the format for cross-fertilization and will provide a new cadre of environmental health scientist who may be equally well at home with the basic and clinical science of a problem. Trainees will be equipped to deal with environmental exposures, how they relate to disease and how their findings may be translated at the patient-, community- and public health- levels. Public Health Relevance: This Institutional Training Grant to establish a Translational Research Training Program in Environmental Health Sciences will create a new cadre of environmental health scientists trained to tackle major societal disease caused by environmental exposures at the patient and community, and public health level.

描述(由申请人提供) 这是重新提交的一份新的机构培训补助金(T32)的申请，以支持宾夕法尼亚大学为博士后和博士后研究员提供的环境健康科学转化研究培训计划。培训计划的中心将是环境毒理学卓越中心(CEET)，这是由NIEHS资助的P30环境健康科学核心中心。CEET是一个翻译环境健康科学中心，专注于影响费城地区的主要社会疾病：包括但不限于肺部和呼吸道疾病，以及生殖、内分泌和发育障碍(包括成人疾病的发育基础)。此外，对涉及氧化应激和基因-环境相互作用的疾病机制也有很大的重视。每年2名博士后研究员将得到为期三年的支持，使稳定状态达到6名博士前研究员。博士后研究员最好是一名博士和一名医学博士，每年将任命一名博士和一名医学博士，并将得到两年的支助，使稳定状态达到4名博士后研究员。博士前研究员将被招募到研究人员的伞形计划，生物医学研究生研究将有资格申请环境健康科学证书计划，这是一个独特的2年制课程，由教学课程作业和三次轮换组成，其中一次必须是基于社区的研究或基于人口的研究轮换，以便提供环境/分子流行病学的动手培训。在完成证书课程的第一年后，博士前研究员将被任命为培训补助金(TG)。培训计划不同于证书计划。所有博士前研究员都必须参加证书计划，但并非所有证书计划的学生都将得到培训计划的支持。那些得到培训计划支持的人预计将进行环境健康科学的论文工作，这将由一名基础和临床科学家导师双重指导，并将参加翻译研究培训的额外课程工作。基础科学家 希望从事环境病因学疾病临床研究的博士后研究员和希望从事导致此类疾病的分子和细胞机制基础研究的临床医生科学家将被任命，任期最长为两年。他们还将接受双重指导。博士后研究员将被要求参加培训计划博士后研究员提供的至少四门课程，以补充他们的知识基础。博士后研究员还将通过CEET的职业发展核心获得额外的指导。这一培训计划提供了交叉受精的形式，并将提供一支新的环境卫生科学家队伍，他们可能同样熟悉基础和临床科学的问题。受训人员将掌握如何处理环境暴露、它们与疾病的关系以及他们的发现如何在患者、社区和公共卫生层面得到转化。 公共卫生相关性：这项旨在建立环境健康科学翻译研究培训计划的机构培训赠款将创建一支新的环境健康科学家队伍，他们接受过培训，以解决由患者和社区以及公共卫生层面的环境暴露引起的重大社会疾病。