Translational Research Training Program in Environmental Health Sciences

这项申请是T32环境卫生机构培训补助金的第一个竞争性延续 科学(EHS)：“EHS中的翻译研究培训计划”(T32-ES019851)，在 宾夕法尼亚大学(宾夕法尼亚)。这一培训赠款是唯一专门支持正式 宾夕法尼亚大学博士前和博士后水平的EHS研究培训，并满足基于以下方面的重大需求 学员对环境及其健康影响的兴趣和生物医学工作人员的需求。世界银行的使命是 T32培训计划旨在培养下一代环境健康科学家 环境暴露导致疾病的机制，并将这些发现转化为 有效预防和治疗，改善公共卫生。培训计划强调 翻译研究的四大支柱：长凳、床边、社区和政策。研究性培训体现了 宾夕法尼亚大学P30环境健康科学核心中心的翻译研究主题 卓越的环境毒理学(CEET)。这些主题是由以下情况决定的 具有影响宾夕法尼亚州实际位置费城地区的环境病原学的疾病。 培训是通过EHS证书计划的课程作业提供的，该课程包括一个可选的 社区环境健康轮换，通过进行全职翻译研究项目合作- 在可能的情况下，由基础科学家和临床科学家指导，以产生EHS的新知识。这个 42名杰出的培训助学金教员来自宾夕法尼亚大学和费城儿童医院，14名 临床科学家。培训补助金支持共同要素，包括一个研究俱乐部、一个专门的 研讨会系列，致力于翻译研究主题和可选外部研究的年度研讨会，网址： 美国环保局、ATSDR和寂静之春研究所为对政策和人类健康评估感兴趣的学员提供培训。 T32奖项目前支持三名博士后研究员就EHS主题进行论文研究 和四名博士后研究员进行有指导的EHS研究。对博士前实习生的资助总额为 三年(第二年完成EHS证书课程并完成两年论文研究)和 博士后实习生将获得长达两年的支持。实习生将为一系列职业生涯做好准备 就业部门，例如学术界(EHS、药理学和毒理学)、政府机构(例如美国- EPA、CDC、FDA、NTP、NIEHS)；以及工业(药品、食品、化妆品和纳米技术)。15名实习生 在该培训计划的前四年得到支持，并发表了41篇论文；所有博士后 已经离开该项目的研究员已经担任了教职。在下一个资金周期中，我们要求 相同数量的博士后(3个)和博士后(4个)。

This application is the first competing continuation of a T32 Institutional Training Grant in Environmental Health Sciences (EHS) entitled: “Translational Research Training Program in EHS” (T32-ES019851) at the University of Pennsylvania (Penn). This training grant is the only dedicated mechanism to support formalized EHS research training at the pre- and post-doctoral level at Penn and meets a significant need based on trainee interest in the environment and its health impact and biomedical work force need. The mission of the T32 Training Program is to train the next generation of environmental health scientists in the mechanisms by which environmental exposures cause disease and to translate these findings into effective prevention and treatment and improvements in public health. The training program emphasizes the four pillars of translational research, bench, bedside, community and policy. The research training reflects the translational research themes of Penn's P30 Environmental Health Sciences Core Center, the Center of Excellence in Environmental Toxicology (CEET). These themes have been dictated by the incidence of disease that have environmental etiology that affect the Philadelphia region, the physical location of Penn. Training is provided through course work from the Certificate Program in EHS which includes an optional Community Environmental Health Rotation, by conducting a full-time translational research project co- mentored where possible by a basic-scientist and clinician scientist to generate new knowledge in EHS. The 42 distinguished training grant faculty come from Penn and Children's Hospital of Philadelphia and 14 are clinician scientists. The training grant supports common elements including a research club, a dedicated seminar series, an annual symposium dedicated to a translational research theme and optional externships at US EPA, ATSDR and the Silent Spring Institute for trainees interested in policy and human health assessment. The T32 award currently supports three predoctoral fellows to conduct dissertation research on an EHS topic and four postdoctoral fellows to perform mentored EHS research. Predoctoral trainees are supported for a total of three years (2nd year completion of the Certificate Program in EHS and two years dissertation research) and postdoctoral trainees are supported for up to two years. Trainees will be prepared for a suite of careers in the employment sector e.g. academia (in EHS, Pharmacology and Toxicology), government agencies (e.g. US- EPA, CDC, FDA, NTP, NIEHS); and industry (drug, food, cosmetic and nanotechnology). Fifteen trainees were supported in the first four years of this training program and published 41 papers; all the postdoctoral fellows that have left the program have assumed faculty positions. In the next cycle of funding we request an identical number of predoctoral (3) and postdoctoral slots (4).