Translational Research Training Program in Environmental Health Sciences

该申请是T32环境卫生机构培训补助金的第一个竞争性延续 科学（EHS）题为：“EHS转化研究培训计划”（T32-ES 019851）在 宾夕法尼亚大学（Penn）这一培训补助金是唯一专门用于支持正规化培训的机制。 EHS研究培训在宾夕法尼亚大学的博士前和博士后水平，并满足了基于以下方面的重大需求 受训者对环境及其健康影响和生物医学劳动力需求的兴趣。联合国的使命 T32培训计划旨在培养下一代环境卫生科学家， 环境暴露导致疾病的机制，并将这些发现转化为 有效预防和治疗以及改善公共卫生。培训计划强调， 翻译研究的四大支柱，长凳，床边，社区和政策。研究培训反映了 宾夕法尼亚大学P30环境健康科学核心中心的转化研究主题， 卓越环境毒理学（CEET）。这些主题是由以下事件决定的： 具有影响费城地区（宾夕法尼亚州的物理位置）的环境病因学的疾病。 通过EHS证书课程提供培训，其中包括可选的 社区环境卫生轮换，通过进行全职的转化研究项目合作， 在可能的情况下，由基础科学家和临床科学家指导，以产生EHS方面的新知识。的 42名杰出的培训补助金教师来自宾夕法尼亚大学和费城儿童医院，14名来自 临床科学家培训补助金支持共同的要素，包括一个研究俱乐部， 研讨会系列，一个致力于翻译研究主题的年度研讨会和可选的校外实习， 美国环保署、美国毒物和疾病登记署和寂静的春天研究所，为对政策和人类健康评估感兴趣的学员提供培训。 T32奖目前支持三名博士前研究员就EHS主题进行论文研究 和四名博士后研究员进行指导EHS研究。博士前培训生的支持总额 三年（第二年完成EHS证书课程和两年的论文研究）， 对博士后学员的支助最长为两年。学员将为一套职业生涯做好准备， 就业部门，如学术界（EHS、药理学和毒理学）、政府机构（如美国- EPA、CDC、FDA、NTP、NIEHS）;以及工业（药品、食品、化妆品和纳米技术）。15名受训人员 在该培训计划的前四年获得支持，发表了41篇论文;所有博士后 离开这个项目的研究员都担任了教职。在下一个供资周期，我们要求 博士前（3）和博士后（4）的相同数量。

This application is the first competing continuation of a T32 Institutional Training Grant in Environmental Health Sciences (EHS) entitled: “Translational Research Training Program in EHS” (T32-ES019851) at the University of Pennsylvania (Penn). This training grant is the only dedicated mechanism to support formalized EHS research training at the pre- and post-doctoral level at Penn and meets a significant need based on trainee interest in the environment and its health impact and biomedical work force need. The mission of the T32 Training Program is to train the next generation of environmental health scientists in the mechanisms by which environmental exposures cause disease and to translate these findings into effective prevention and treatment and improvements in public health. The training program emphasizes the four pillars of translational research, bench, bedside, community and policy. The research training reflects the translational research themes of Penn's P30 Environmental Health Sciences Core Center, the Center of Excellence in Environmental Toxicology (CEET). These themes have been dictated by the incidence of disease that have environmental etiology that affect the Philadelphia region, the physical location of Penn. Training is provided through course work from the Certificate Program in EHS which includes an optional Community Environmental Health Rotation, by conducting a full-time translational research project co- mentored where possible by a basic-scientist and clinician scientist to generate new knowledge in EHS. The 42 distinguished training grant faculty come from Penn and Children's Hospital of Philadelphia and 14 are clinician scientists. The training grant supports common elements including a research club, a dedicated seminar series, an annual symposium dedicated to a translational research theme and optional externships at US EPA, ATSDR and the Silent Spring Institute for trainees interested in policy and human health assessment. The T32 award currently supports three predoctoral fellows to conduct dissertation research on an EHS topic and four postdoctoral fellows to perform mentored EHS research. Predoctoral trainees are supported for a total of three years (2nd year completion of the Certificate Program in EHS and two years dissertation research) and postdoctoral trainees are supported for up to two years. Trainees will be prepared for a suite of careers in the employment sector e.g. academia (in EHS, Pharmacology and Toxicology), government agencies (e.g. US- EPA, CDC, FDA, NTP, NIEHS); and industry (drug, food, cosmetic and nanotechnology). Fifteen trainees were supported in the first four years of this training program and published 41 papers; all the postdoctoral fellows that have left the program have assumed faculty positions. In the next cycle of funding we request an identical number of predoctoral (3) and postdoctoral slots (4).