An Intravascular Bioartificial Pancreas (iBAP)

血管内生物人工胰腺 (iBAP)

基本信息

批准号：
8823183
负责人：
Charles Blaha
金额：
$ 22.44万
依托单位：
SILICON KIDNEY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-23 至 2017-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8823183
关键词：
Affect Allogenic American Animal Model Biological Markers Blood Blood Platelets Blood Pressure Blood coagulation Blood flow C-reactive protein Canis familiaris Characteristics Deposition Devices Diffusion Drops Exposure to Glucose Haptoglobins Healthcare Systems Hemolysis Hour Hypertension Hypotension Immune Implant In Vitro Inflammation Injection of therapeutic agent Insulin Insulin-Dependent Diabetes Mellitus Interleukin-6 Islets of Langerhans Transplantation Kidney Kinetics Membrane Modeling Nutrient Organ Outcome Oxygen Pancreas Pancreas Transplantation Patients Performance Permeability Phase Physiological Polymers Preclinical Testing Production Proteins Quality of life Shapes Side Silicon Small Business Innovation Research Grant Thick Thrombosis Thrombus Ultrafiltration Variant Venous clinically relevant common treatment cost cytokine density glucose monitor glycemic control improved in vivo islet lactate dehydrogenase 3 nanopore pancreas development phase 2 study pressure public health relevance solute success

项目摘要

DESCRIPTION (provided by applicant): Approximately 3 million Americans and around 24 million people worldwide are affected by Type 1 Diabetes (T1D). Glucose monitoring followed by exogenous insulin injection, allogeneic whole organ pancreas transplantation, and allogeneic islet transplantation are the most common treatments for T1D. These treatments have achieved glycemic control for many patients but result in serious complications. A bioartificial pancreas is a promising treatment for T1D because it contains functional islets. Unfortunately previous attempts at BAP development have been severely limited by insufficient mass transfer within the islet chamber. The founders of Silicon Kidney have developed silicon nanopore membranes (SNM) to achieve high-efficiency blood ultrafiltration while selectively retaining specific solutes for the Bioartificial Kidney Project and this project's successes are directly transferrable to the iBAP. The ultra-high-hydraulic-permeable characteristic of the SNM will enable appropriate mass transport (especially oxygen, glucose, and insulin) within the islet chamber to achieve optimal islet performance, while the ultra-selective characteristic of the SNM enable unprecedented immunoisolation. The iBAP will be connected between an arterial and venous graft and a pressure drop across the Islet Chamber will produce an ultrafiltrate flow within the Islet Chamber. The ultrafiltrate will provide convective mass transport of nutrients (especially oxygen and glucose) to the Islet Chamber and insulin to the blood channels. The long-term objective of our project is to create the intravascular Bioartificial Pancreas (iBAP) to achieve exogenous insulin independent glycemic control of Type 1 Diabetes (T1D). This Phase I SBIR project will prove the feasibility of the iBAP by demonstrating proper Islet Chamber performance in vitro and iBAP hemocompatibility in vivo.

描述（由适用提供）：全球约有300万美国人和大约2400万人受1型糖尿病（T1D）的影响。葡萄糖监测，然后进行外源胰岛素注射，同种异体整个器官胰腺移植和同种异体胰岛移植是T1D的最常见治疗方法。这些治疗方法已为许多患者实现了血糖控制，但导致严重的并发症。生物人工胰腺是 T1D的一种有希望的治疗方法，因为它包含功能性胰岛。不幸的是，先前对BAP发育的尝试受到胰岛室内传质不足的不足而受到严重限制。硅肾脏的创始人已经开发了硅纳米孔膜（SNM），以实现高效的血液超滤，同时选择性保留特定的溶液对于生物肾脏项目，该项目的成功直接转移到 IBAP。 SNM的超高氢渗透性特征将使胰岛腔中的适当的质量转运（尤其是氧，葡萄糖和胰岛素）在胰岛腔中实现最佳胰岛性能，而SNM的超选择性特征则可以实现前所未有的免疫溶剂化。 IBAP将连接在伪影和静脉移植物之间，并且在胰岛腔室中的压降将在胰岛腔内产生超滤流量。超滤将提供营养（尤其是氧气和葡萄糖）到胰岛腔的对流质量运输，并向血液通道胰岛素提供胰岛素。我们项目的长期目标是创建血管内生物人工胰腺（IBAP），以实现1型糖尿病（T1D）的外源性胰岛素独立的血糖控制。该阶段I SBIR项目将通过在体内展示适当的胰岛腔室性能来证明IBAP的可行性。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.

DOI：
10.1039/c7lc00096k
发表时间：
2017-05-16
期刊：
Lab on a chip
影响因子：
6.1
作者：
Song S;Blaha C;Moses W;Park J;Wright N;Groszek J;Fissell W;Vartanian S;Posselt AM;Roy S
通讯作者：
Roy S

Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.

修正：血管内生物人工胰腺装置 (iBAP) 具有硅纳米孔膜 (SNM)，用于在对流质量传输下封装胰岛。

DOI：
10.1039/c7lc90058a
发表时间：
2017
期刊：
Lab on a chip
影响因子：
6.1
作者：
Song,Shang;Blaha,Charles;Moses,Willieford;Park,Jaehyun;Wright,Nathan;Groszek,Joey;Fissell,William;Vartanian,Shant;Posselt,AndrewM;Roy,Shuvo
通讯作者：
Roy,Shuvo