权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

An Intravascular Bioartificial Pancreas (iBAP)

血管内生物人工胰腺 (iBAP)

基本信息

批准号：
8823183
负责人：
Charles Blaha
金额：
$ 22.44万
依托单位：
SILICON KIDNEY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-23 至 2017-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8823183
关键词：
Affect Allogenic American Animal Model Biological Markers Blood Blood Platelets Blood Pressure Blood coagulation Blood flow C-reactive protein Canis familiaris Characteristics Deposition Devices Diffusion Drops Exposure to Glucose Haptoglobins Healthcare Systems Hemolysis Hour Hypertension Hypotension Immune Implant In Vitro Inflammation Injection of therapeutic agent Insulin Insulin-Dependent Diabetes Mellitus Interleukin-6 Islets of Langerhans Transplantation Kidney Kinetics Membrane Modeling Nutrient Organ Outcome Oxygen Pancreas Pancreas Transplantation Patients Performance Permeability Phase Physiological Polymers Preclinical Testing Production Proteins Quality of life Shapes Side Silicon Small Business Innovation Research Grant Thick Thrombosis Thrombus Ultrafiltration Variant Venous clinically relevant common treatment cost cytokine density glucose monitor glycemic control improved in vivo islet lactate dehydrogenase 3 nanopore pancreas development phase 2 study pressure public health relevance solute success

项目摘要

DESCRIPTION (provided by applicant): Approximately 3 million Americans and around 24 million people worldwide are affected by Type 1 Diabetes (T1D). Glucose monitoring followed by exogenous insulin injection, allogeneic whole organ pancreas transplantation, and allogeneic islet transplantation are the most common treatments for T1D. These treatments have achieved glycemic control for many patients but result in serious complications. A bioartificial pancreas is a promising treatment for T1D because it contains functional islets. Unfortunately previous attempts at BAP development have been severely limited by insufficient mass transfer within the islet chamber. The founders of Silicon Kidney have developed silicon nanopore membranes (SNM) to achieve high-efficiency blood ultrafiltration while selectively retaining specific solutes for the Bioartificial Kidney Project and this project's successes are directly transferrable to the iBAP. The ultra-high-hydraulic-permeable characteristic of the SNM will enable appropriate mass transport (especially oxygen, glucose, and insulin) within the islet chamber to achieve optimal islet performance, while the ultra-selective characteristic of the SNM enable unprecedented immunoisolation. The iBAP will be connected between an arterial and venous graft and a pressure drop across the Islet Chamber will produce an ultrafiltrate flow within the Islet Chamber. The ultrafiltrate will provide convective mass transport of nutrients (especially oxygen and glucose) to the Islet Chamber and insulin to the blood channels. The long-term objective of our project is to create the intravascular Bioartificial Pancreas (iBAP) to achieve exogenous insulin independent glycemic control of Type 1 Diabetes (T1D). This Phase I SBIR project will prove the feasibility of the iBAP by demonstrating proper Islet Chamber performance in vitro and iBAP hemocompatibility in vivo.

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.

血管内生物人工胰腺器件（IBAP），带有硅纳米孔膜（SNM），用于对流质量运输下的胰岛封装。

DOI：
10.1039/c7lc00096k
发表时间：
2017-05-16
期刊：
Lab on a chip
影响因子：
6.1
作者：
Song S;Blaha C;Moses W;Park J;Wright N;Groszek J;Fissell W;Vartanian S;Posselt AM;Roy S
通讯作者：
Roy S

Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.

修正：血管内生物人工胰腺装置 (iBAP) 具有硅纳米孔膜 (SNM)，用于在对流质量传输下封装胰岛。

DOI：
10.1039/c7lc90058a
发表时间：
2017
期刊：
Lab on a chip
影响因子：
6.1
作者：
Song,Shang;Blaha,Charles;Moses,Willieford;Park,Jaehyun;Wright,Nathan;Groszek,Joey;Fissell,William;Vartanian,Shant;Posselt,AndrewM;Roy,Shuvo
通讯作者：
Roy,Shuvo