A Pilot Gaming Adherence Program for Youth Living with HIV

针对艾滋病毒青少年的游戏依从性试点计划

• 批准号: 8694061
• 负责人: LARRY K BROWN
• 金额: $ 46.51万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-28 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8694061
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Adolescent and Young Adult; Adult; Age; Anti-Retroviral Agents; Attitude; Behavior; Behavioral; Biological; CD4 Lymphocyte Count; CD4 Positive T Lymphocytes; Caring; Cell Count; Control Groups; Data; Development; Devices; Drug resistance; Event; Feedback; HIV; HIV Seropositivity; HIV-1; Health; Health Benefit; Individual; Intervention; Intervention Trial; Interview; Knowledge; Lead; Life; Measures; Medical; Methods; Modeling; Monitor; Motivation; Outcome; Participant; Patient Self-Report; Persons; Pharmaceutical Preparations; Pilot Projects; RNA; Randomized; Regimen; Research; Self Efficacy; System; Target Populations; Technology; Telephone; Testing; Treatment Efficacy; Viral; Viral Load result; Visit; Youth; base; comparison group; drug resistant virus; experience; improved; interest; medical appointment; monitoring device; mortality; new technology; novel; pill; post intervention; programs; skills; sound; theories; tool; transmission process; treatment adherence

DESCRIPTION (provided by applicant): Despite need for consistent adherence to medical care, youth living with HIV (YLWH) have suboptimal rates of retention in care and adherence to antiretroviral medication (ARV) treatment. There are few adherence studies with YLWH and the results are mixed, so there is a great need for the development of novel interventions. Results of adult HIV adherence studies indicate that participants are interested in using technology-based methods and are most receptive toward interventions that couple technological devices with motivational components. Pill taking monitoring devices have been found to be a sensitive measure of adherence to ARV medications, but do not lead to sustained improvements in adherence or intrinsic motivation when used alone. Building on this knowledge, this study will examine a multi-level technology that integrates a medication monitoring device (Vitality Cap) WITH an interactive smartphone based app/game that is attractive and engaging to YLWH. This multi-level approach will integrate theory driven content with novel, but intuitive, technology to improve HIV treatment adherence. In this study, each opening of the pill bottle will allow access to the app/game on the smartphone via data transferred wirelessly from the bottle cap (Vitality Cap) to the phone. This developmental project will adapt and refine a smartphone app/game to include content consistent with the Information-Motivation-Behavioral Skills (IMB) Model. Creation and adaptation will occur from in-depth interviews with YLWH on ART (n=25) and an open trial of the Intervention (n=20). While gaming, participants will experience absorbing action-oriented adventures that increase information about their health (e.g. knowledge about HIV treatment), improve motivation (e.g. action-figures experience health benefits of adherence), and build skills (e.g. utilize clinicians as partners). A small randomized controlled pilot study (24 weeks) among 60 YLWH will examine the preliminary efficacy of the IMB Gaming Adherence Intervention (integration of the Vitality Cap with the IMB informed app/game) compared to a comparison group who receive the Vitality Cap and smartphone but no IMB game, on adherence and biological measures.

描述（由申请人提供）：尽管需要持续遵守医疗保健，但艾滋病毒（YLWH）的青年在护理和遵守抗逆转录病毒药物（ARV）治疗方面的保留率均高于最佳的保留率。与YLWH的依从性研究很少，结果混合在一起，因此需要开发新的干预措施。成人艾滋病毒依从性研究的结果表明，参与者有兴趣使用基于技术的方法，并且最容易接受将技术设备与动机组成部分相结合的干预措施。已经发现服用监测装置是对ARV药物依从性的敏感度量，但单独使用时不会持续改善依从性或内在动机。在此知识的基础上，这项研究将研究一项多层技术，该技术将药物监控设备（Vitality Cap）与基于交互式智能手机的应用程序/游戏集成在一起，对YLWH具有吸引力。这种多层次的方法将将理论驱动的内容与新颖但直观的技术相结合，以改善HIV治疗依从性。 在这项研究中，丸瓶的每个开口都将允许通过从瓶盖（Vitality Cap）无线传输到手机的数据上访问智能手机上的应用程序/游戏。这个开发项目将适应并完善智能手机应用程序/游戏，包括与信息动机行为技能（IMB）模型一致的内容。创建和适应性将来自对ART的YLWH的深入访谈（n = 25）和干预措施的公开试验（n = 20）。在游戏时，参与者将体验到吸收以动作为导向的冒险，以增加有关其健康的信息（例如，对艾滋病毒治疗的知识），改善动力（例如，行动图（例如，具有遵守健康的健康益处）和建立技能（例如将临床医生作为伴侣）。与接受比较组的比较组相比，在60 YLWH中进行了一项小的随机对照试验研究（24周）将检查IMB游戏依从性干预（将活力帽与IMB知情应用程序/游戏的集成在一起）的初步疗效，这些比较组在接受智能手机和智能手机，但没有IMB游戏，关于ADHERCE和生物学测量。