A Pilot Gaming Adherence Program for Youth Living with HIV

针对艾滋病毒青少年的游戏依从性试点计划

• 批准号: 8554308
• 负责人: LARRY K BROWN
• 金额: $ 53.42万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-28 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8554308
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Adolescent; Adult; Age; Anti-Retroviral Agents; Attitude; Behavior; Behavioral; Biological; CD4 Lymphocyte Count; CD4 Positive T Lymphocytes; Caring; Cell Count; Control Groups; Data; Development; Devices; Drug resistance; Event; Feedback; HIV; HIV Seropositivity; HIV-1; Health; Health Benefit; Individual; Intervention; Intervention Trial; Interview; Knowledge; Lead; Life; Measures; Medical; Methods; Modeling; Monitor; Motivation; Outcome; Participant; Patient Self-Report; Persons; Pharmaceutical Preparations; Pilot Projects; RNA; Randomized; Regimen; Research; Self Efficacy; System; Target Populations; Technology; Telephone; Testing; Treatment Efficacy; Viral; Viral Load result; Visit; Youth; base; comparison group; drug resistant virus; experience; improved; interest; medical appointment; monitoring device; mortality; new technology; novel; pill; post intervention; programs; skills; sound; theories; tool; transmission process; treatment adherence; young adult

DESCRIPTION (provided by applicant): Despite need for consistent adherence to medical care, youth living with HIV (YLWH) have suboptimal rates of retention in care and adherence to antiretroviral medication (ARV) treatment. There are few adherence studies with YLWH and the results are mixed, so there is a great need for the development of novel interventions. Results of adult HIV adherence studies indicate that participants are interested in using technology-based methods and are most receptive toward interventions that couple technological devices with motivational components. Pill taking monitoring devices have been found to be a sensitive measure of adherence to ARV medications, but do not lead to sustained improvements in adherence or intrinsic motivation when used alone. Building on this knowledge, this study will examine a multi-level technology that integrates a medication monitoring device (Vitality Cap) WITH an interactive smartphone based app/game that is attractive and engaging to YLWH. This multi-level approach will integrate theory driven content with novel, but intuitive, technology to improve HIV treatment adherence. In this study, each opening of the pill bottle will allow access to the app/game on the smartphone via data transferred wirelessly from the bottle cap (Vitality Cap) to the phone. This developmental project will adapt and refine a smartphone app/game to include content consistent with the Information-Motivation-Behavioral Skills (IMB) Model. Creation and adaptation will occur from in-depth interviews with YLWH on ART (n=25) and an open trial of the Intervention (n=20). While gaming, participants will experience absorbing action-oriented adventures that increase information about their health (e.g. knowledge about HIV treatment), improve motivation (e.g. action-figures experience health benefits of adherence), and build skills (e.g. utilize clinicians as partners). A small randomized controlled pilot study (24 weeks) among 60 YLWH will examine the preliminary efficacy of the IMB Gaming Adherence Intervention (integration of the Vitality Cap with the IMB informed app/game) compared to a comparison group who receive the Vitality Cap and smartphone but no IMB game, on adherence and biological measures.

描述（由申请人提供）：尽管需要始终如一地坚持医疗护理，但感染艾滋病毒的青少年 (YLWH) 的护理保留率和抗逆转录病毒药物 (ARV) 治疗的依从率均不理想。 YLWH 的依从性研究很少，而且结果好坏参半，因此非常需要开发新的干预措施。成人艾滋病毒依从性研究的结果表明，参与者对使用基于技术的方法感兴趣，并且最容易接受将技术设备与激励成分相结合的干预措施。服药监测设备已被发现是衡量抗逆转录病毒药物依从性的敏感指标，但单独使用时不会导致依从性或内在动机的持续改善。基于这些知识，本研究将研究一种多层次技术，该技术将药物监测设备（Vitality Cap）与基于智能手机的交互式应用程序/游戏相结合，对 YLWH 有吸引力且有吸引力。这种多层次的方法将理论驱动的内容与新颖而直观的技术相结合，以提高艾滋病毒治疗的依从性。 在这项研究中，每次打开药瓶都可以通过从瓶盖（Vitality Cap）无线传输到手机的数据来访问智能手机上的应用程序/游戏。该开发项目将调整和完善智能手机应用程序/游戏，以包含与信息-动机-行为技能（IMB）模型一致的内容。创作和改编将通过对 YLWH 关于 ART (n=25) 的深入访谈和干预措施的公开试验 (n=20) 进行。在游戏时，参与者将体验到以动作为导向的冒险，从而增加有关他们健康的信息（例如有关艾滋病毒治疗的知识），提高动机（例如动作人物体验坚持的健康益处）并培养技能（例如利用临床医生作为合作伙伴）。一项针对 60 名 YLWH 的小型随机对照试点研究（24 周）将检查 IMB 游戏依从干预（将活力帽与 IMB 知情应用程序/游戏相结合）与接受活力帽和智能手机但没有 IMB 游戏的对照组相比，在依从性和生物测量方面的初步功效。