Integrated system wide characterization of microbiota and host factors influencing intestinal colonization resistance to the healthcare pathogen Clostridium difficile

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Naturally occurring bacteria play an important role in determining patient disease susceptibility, disease progression and ultimately, disease outcome. Over 1000 species of bacteria, contributing 10 times as many cells as found within a single individual. This project seeks to understand these communities, how they confer resistance to infection and how they can be manipulated, both naturally and through controlled introduction of bacteria to prevent disease or improve disease outcome.