Motion Management Using 4D-MRI for Liver Cancer in Radiation Therapy

在肝癌放射治疗中使用 4D-MRI 进行运动管理

• 批准号: 8443466
• 负责人: Jing Cai
• 金额: $ 32.58万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-11 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8443466
• 关键词: 4D Imaging; Accounting; Breathing; Cancer Patient; Clinic; Clinical; Dose; Effectiveness; Foundations; Generic Drugs; Goals; Human; Image; Imagery; Imaging Device; Imaging Techniques; Individual; Injury; Lead; Liver neoplasms; Magnetic Resonance Imaging; Malignant neoplasm of liver; Measurement; Methods; Modeling; Motion; Normal tissue morphology; Operative Surgical Procedures; Organ; Patients; Phase; Physicians; Radiation; Radiation therapy; Research; Risk; Scanning; Signal Transduction; Techniques; Technology; Testing; Therapeutic; Time; Tissues; Toxic effect; Treatment outcome; Tumor Volume; base; chemotherapy; digital; human subject; improved; novel; public health relevance; radiation hazard; respiratory; soft tissue; tool; treatment planning; tumor

DESCRIPTION (provided by applicant): Respiratory motion poses great challenges to radiotherapy of liver cancer. 4D-CT is the current clinical standard for imaging organ respiratory motion. However, it 1) involves high imaging dose to the patient due to prolonged scan time, and 2) provides insufficient soft tissue contrast for imaging liver tumor. Conversely, MRI has excellent soft-tissue contrast and has no known radiation hazard for clinical imaging. MRI-based 4D imaging (4D-MRI) is thus highly desired to improve the visualization of soft-tissue respiratory motion and the delineation of target volume of moving liver tumors. At present, there is no established 4D-MRI technique for radiotherapy. Our long-term goal is to establish a novel 4D-MRI based motion management framework for radiotherapy. The objective of this application is to develop and evaluate a clinical feasible 4D-MRI technique for improved imaging of liver tumor respiratory motion. Our overall hypothesis is that integration of 4D-MRI into radiotherapy of liver cancer will allow for more accurate delineation of tumor internal target volume (ITV). This hypothesis will be tested via two specific aims. Aim 1 will develop and validate a retrospective 4D-MRI technique that can be immediately implemented in the clinic. Aim 2 will evaluate accuracy of the tumor ITV determined from 4D-MRI and its dosimetric impact on treatment planning in liver cancer patient cases. Successful completion of these studies will provide the foundation required to establish a novel 4D-MRI based motion management framework for radiation therapy of liver cancer, and the necessary information to support a later larger scale study to further enhance the 4D-MRI tool. The fully developed 4D-MRI technology will improve our ability to more precisely deliver radiation treatment to tumor and mitigate radiation-induced injury to surrounding normal tissues.

描述（由申请人提供）：呼吸运动对肝癌的放射疗法构成了巨大挑战。 4D-CT是当前用于成像器官呼吸运动的临床标准。然而，它1）由于扫描时间的延长而导致患者的高成像剂量，而2）对于成像肝肿瘤的软组织对比度不足。相反，MRI具有出色的软组织对比度，并且对临床成像没有已知的辐射危害。因此，高度希望基于MRI的4D成像（4D-MRI）可以改善软组织呼吸运动的可视化和移动肝肿瘤的目标体积的描述。目前，还没有建立的4D-MRI技术用于放射疗法。我们的长期目标是为放射疗法建立一个新型的基于4D-MRI的运动管理框架。该应用的目的是开发和评估临床可行的4D-MRI技术，以改善肝肿瘤呼吸运动的成像。我们的总体假设是将4D-MRI整合到肝脏放射疗法中 癌症将使肿瘤内部目标体积（ITV）更准确地描述。该假设将通过两个特定目的进行检验。 AIM 1将开发并验证可以在诊所中立即实施的回顾性4D-MRI技术。 AIM 2将评估由4D-MRI确定的肿瘤ITV的准确性及其对肝癌患者病例治疗计划的剂量计。这些研究的成功完成将为建立新型的4D-MRI基于4D-MRI的运动管理框架，以供肝癌放射治疗，并提供必要的信息，以支持后来的大规模研究，以进一步增强4D-MRI工具。完全开发的4D-MRI技术将提高我们更精确地提供辐射治疗的能力，并减轻辐射引起的损伤对周围正常组织。