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Motion Management Using 4D-MRI for Liver Cancer in Radiation Therapy

在肝癌放射治疗中使用 4D-MRI 进行运动管理

基本信息

批准号：
8824888
负责人：
Jing Cai
金额：
$ 24.64万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-11 至 2016-12-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Respiratory motion poses great challenges to radiotherapy of liver cancer. 4D-CT is the current clinical standard for imaging organ respiratory motion. However, it 1) involves high imaging dose to the patient due to prolonged scan time, and 2) provides insufficient soft tissue contrast for imaging liver tumor. Conversely, MRI has excellent soft-tissue contrast and has no known radiation hazard for clinical imaging. MRI-based 4D imaging (4D-MRI) is thus highly desired to improve the visualization of soft-tissue respiratory motion and the delineation of target volume of moving liver tumors. At present, there is no established 4D-MRI technique for radiotherapy. Our long-term goal is to establish a novel 4D-MRI based motion management framework for radiotherapy. The objective of this application is to develop and evaluate a clinical feasible 4D-MRI technique for improved imaging of liver tumor respiratory motion. Our overall hypothesis is that integration of 4D-MRI into radiotherapy of liver cancer will allow for more accurate delineation of tumor internal target volume (ITV). This hypothesis will be tested via two specific aims. Aim 1 will develop and validate a retrospective 4D-MRI technique that can be immediately implemented in the clinic. Aim 2 will evaluate accuracy of the tumor ITV determined from 4D-MRI and its dosimetric impact on treatment planning in liver cancer patient cases. Successful completion of these studies will provide the foundation required to establish a novel 4D-MRI based motion management framework for radiation therapy of liver cancer, and the necessary information to support a later larger scale study to further enhance the 4D-MRI tool. The fully developed 4D-MRI technology will improve our ability to more precisely deliver radiation treatment to tumor and mitigate radiation-induced injury to surrounding normal tissues.

描述（申请人提供）：呼吸运动对肝癌的放射治疗提出了巨大的挑战。 4D-CT是目前器官呼吸运动成像的临床标准。然而，它 1) 由于扫描时间延长而涉及患者的高成像剂量，2) 为肝脏肿瘤成像提供的软组织对比度不足。相反，MRI 具有出色的软组织对比度，并且对临床成像没有已知的辐射危害。因此，非常需要基于 MRI 的 4D 成像 (4D-MRI) 来改善软组织呼吸运动的可视化和移动肝脏肿瘤目标体积的描绘。目前，还没有成熟的4D-MRI放射治疗技术。我们的长期目标是建立一种基于 4D-MRI 的新型放射治疗运动管理框架。本应用的目的是开发和评估临床可行的 4D-MRI 技术，以改善肝脏肿瘤呼吸运动的成像。我们的总体假设是，将 4D-MRI 整合到肝脏放射治疗中癌症将允许更准确地描绘肿瘤内部目标体积（ITV）。这一假设将通过两个具体目标进行检验。目标 1 将开发并验证可立即在诊所实施的回顾性 4D-MRI 技术。目标 2 将评估 4D-MRI 确定的肿瘤 ITV 的准确性及其对肝癌患者病例治疗计划的剂量影响。这些研究的成功完成将为建立用于肝癌放射治疗的新型基于 4D-MRI 的运动管理框架提供所需的基础，并为支持后续更大规模的研究以进一步增强 4D-MRI 工具提供必要的信息。成熟的4D-MRI技术将提高我们更精确地对肿瘤进行放射治疗并减轻放射线对周围正常组织造成的损伤的能力。