Miami Regional Coordinating Center for NINDS Stroke Trials Network

描述(由申请人提供)：本提案概述了迈阿密大学成为卒中试验网络区域协调中心(RCC)的申请。迈阿密RCC的目标是：a)提供强大和高效的基础设施，以实施高质量的研究性临床试验，解决急性中风的治疗、预防和康复问题； B)利用内部和地区资源加强中风试验网络；c)培训下一代中风临床和翻译研究人员。迈阿密RCC包括一个庞大的参与急诊护理、康复和儿科医院的网络，这些医院横跨美国东南部最大的大都市区南佛罗里达州，以确保以西班牙裔为主的种族多元化人口的强劲招生，反映了美国不断变化的人口结构。我们的卒中计划有成功的记录，参与了许多NINDS急性和二级预防卒中试验，并参与了其他网络(Neuro-Next，SPIRP)。通过我们全面的卒中中心、扩展的转诊网络和多学科的专业知识，我们将建立与院前急救服务、急诊医学、血管神经外科、介入神经病学、神经危重护理、儿科神经病学和神经康复以及学术和私营机构合作的密切合作伙伴关系，以登记和管理潜在的研究参与者。我们还可以将独特的资源带到网络中。尖端研究人员在临床前卒中、干细胞、人类基因组学、生物库、脑库和迈阿密CTSI等领域的集成合作使我们在开发、提出和实施新颖的翻译早期项目方面处于独特的地位。神经学方面的大型住院医师和研究员培训计划，该机构的多学科教育资源，以及 我们指导临床研究人员的记录使我们的中心能够通过结构化的指导计划有效地培训中风研究人员进行临床和翻译研究。因此，我们拥有深度和广度的专业知识和资源，可以在卒中试验网络中成功地发挥RCC的作用。

DESCRIPTION (provided by applicant): This proposal outlines the University of Miami's application to become a Regional Coordinating Center (RCC) in the Stroke Trials Network. The goals of the Miami RCC are to: a) provide a robust and efficient infrastructure to implement high-quality research clinical trials that address acute stroke treatment, prevention and recovery; b) leverage the internal and regional resources to enhance the Stroke Trials Network; c) train the next generation of stroke clinical and translational researchers. The Miami RCC encompasses a large network of participating acute care, rehabilitation and pediatric hospitals that span South Florida, the largest metropolitan area in the Southeast, to ensure robust enrollment of an ethnically diverse, predominantly Hispanic, population that reflects the changing demographics of the US. Our stroke program has a successful track record of participating in numerous NINDS acute and secondary prevention stroke trials, and is involved in other networks (Neuro-NEXT, SPIRP). Through our Comprehensive Stroke Center, extended referral network and multidisciplinary expertise, we will build upon the close partnership with pre-hospital Emergency Services, Emergency Medicine, Vascular Neurosurgery, Interventional Neurology, Neuro-Critical Care, Pediatric Neurology and Neurorehabilitation, as well as on academic-private institutional collaborations, to enroll and manage potential study participants. We also have unique resources that we can bring to the network. Integrated collaboration among cutting edge researchers in the areas of preclinical stroke, stem cells, human genomics, biorepository, brain bank, and the Miami CTSI make us uniquely positioned to develop, propose and implement novel translational early phase projects. The large residency and fellowship training programs in Neurology, the multidisciplinary educational resources in the institution, and our track record of instructing clinical researchers position our center to effectively train strok researchers in clinical and translational research through a structured mentored program. Therefore, we have the depth and breadth of expertise and resources to successfully function as a RCC in the Stroke Trials Network.