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Natural Product Treatments for Leishmaniasis

治疗利什曼病的天然产品

基本信息

批准号：
8721327
负责人：
BILL J BAKER
金额：
$ 22.43万
依托单位：
UNIVERSITY OF SOUTH FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-15 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8721327
关键词：
Affect Algae Amphotericin B Antarctic Attention Biodiversity Biological Assay Biological Factors Cachexia Cessation of life Chemicals Chemistry Collection Complement Country Cutaneous Cutaneous Leishmaniasis Data Developed Countries Development Disease Disease model Drug resistance Ecosystem Evaluation Fermentation Fever Generations HIV Hepatosplenomegaly Human Incidence Infection Inhibitory Concentration 50 Invertebrates Leishmania Leishmania donovani Leishmaniasis Lesion Life Malignant Neoplasms Marines Military Personnel Miltefosine Modeling Morbidity - disease rate Paclitaxel Parasites Pharmaceutical Preparations Pharmacologic Substance Plants Production Prunella vulgaris Reproduction spores Research Research Priority Resources Risk Role Sampling Sea Sea Ice Soil Source Southern Ocean Tropical Disease United States Food and Drug Administration Visceral Visceral Leishmaniasis World Health Organization base climate change cytopenia cytotoxicity drug development drug discovery endophytic fungi follow-up fungus indexing interest macrophage microbial microbial community microorganism mortality neglect novel operation public health relevance public-private partnership screening small molecule

项目摘要

DESCRIPTION (provided by applicant): Leishmaniasis exacts a staggering toll of mortality and morbidity on the developing world. Infection with parasites of the genus Leishmania causes a spectrum of disease in humans ranging from self-healing cutaneous lesions to life-threatening visceral infections. Two million new cases of leishmaniasis occur annually (1.5 million for cutaneous leishmaniasis and 500,000 for visceral leishmaniasis and over 350 million people are at risk of acquiring leishmaniasis, which is one of six diseases on the World Health Organization Tropical Disease Research (WHO TDR) list for priority research. The incidence of leishmaniasis may be increasing, and there is also growing interest in leishmaniasis in industrialized countries, in part due to the increase of Leishmania-HIV co-infection and the importance of the disease in current military operations. Leishmaniasis is most often treated by parenteral administration of toxic drugs such as pentavalent antimonials and amphotericin B, and drug resistance is becoming a problem. For the treatment of cutaneous leishmaniasis, a variety of drugs are frequently used, but none is effective against all species of the parasite that cause cutaneous disease. Herein we propose to investigate several niche sources of unstudied or understudied biodiversity in the search for new natural product chemotypes for treating leishmaniasis. Natural products represent 9 of 13 anti-parasitic drugs approved by the U.S. Food and Drug Administration in the past 25 years, highlighting the important role of this drug discovery resource for antileishmanial drug discovery research.

描述（由申请人提供）：利什曼病在发展中国家造成了惊人的死亡率和发病率。感染利什曼原虫属寄生虫可在人类中引起一系列疾病，从自愈的皮肤病变到危及生命的内脏感染。每年有200万新发利什曼病病例（皮肤利什曼病150万例，内脏利什曼病50万例），超过3.5亿人面临感染利什曼病的风险，利什曼病是世界卫生组织热带病研究（世卫组织热带病研究）重点研究清单上的六种疾病之一。利什曼病的发病率可能在增加，工业化国家对利什曼病的关注也在增加。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral.

DOI：
10.1021/ol500792x
发表时间：
2014-05-16
期刊：
ORGANIC LETTERS
影响因子：
5.2
作者：
von Salm, Jacqueline L.;Wilson, Nerida G.;Vesely, Brian A.;Kyle, Dennis E.;Cuce, Jason;Baker, Bill J.
通讯作者：
Baker, Bill J.

Spongian Diterpenoids Derived from the Antarctic Sponge Dendrilla antarctica Are Potent Inhibitors of the Leishmania Parasite.

DOI：
10.1021/acs.jnatprod.0c00025
发表时间：
2020-05-22
期刊：
Journal of natural products
影响因子：
5.1
作者：
Shilling AJ;Witowski CG;Maschek JA;Azhari A;Vesely BA;Kyle DE;Amsler CD;McClintock JB;Baker BJ
通讯作者：
Baker BJ

Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.