Development of a new light source for parallel optical coherence tomograph

并行光学相干断层扫描仪新型光源的研制

• 批准号: 8675853
• 负责人: Hui Cao
• 金额: $ 20.19万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8675853
• 关键词: Air; Area; Biomedical Engineering; Blood Vessels; Cardiovascular system; Childhood; Clinical Medicine; Cystic Fibrosis; Dermatology; Development; Devices; Diagnosis; Disease; Dyes; Esophagus; Exhibits; Eye; Future; Generations; Grant; Image; Imaging Phantoms; Interdisciplinary Study; Lasers; Light; Lighting; Location; Lung; Medicine; Membrane; Methods; Morphologic artifacts; Motion; Mucous body substance; Optical Coherence Tomography; Optics; Organ; Outcome; Pharmaceutical Preparations; Physicians; Plague; Public Health; Pulmonology; Pump; Research; Research Project Grants; Sampling; Scanning; Scientist; Semiconductors; Series; Skin; Source; Speed; Surface; System; Translational Research; Validation; Work; arm; base; bioimaging; density; design; detector; gastrointestinal; new technology; novel; optical imaging; photonics; prevent; prototype; public health relevance; quantum; research study; response; two-dimensional

DESCRIPTION (provided by applicant): The ability of optical coherence tomography (OCT) to perform high-speed, micron-scale, cross-sectional imaging has transformed ophthalmic medicine and has the potential to transform cardiovascular, gastrointestinal, pulmonary, and dermatological medicine. Current OCT systems use raster scanning, a serial method for acquiring depth reflectivity profiles at different locations on a sample. Shifting the paradigm fro serial to parallel OCT will enable dramatically higher imaging rates. Higher imaging rates will enable the comprehensive quantification of previously inaccessible disease states including (a) mucus flow rates and ciliary motion dynamics in cystic fibrosis and (b) response to new drug treatments in disorders of epidermal differentiation. The missing component to enable parallel OCT is a bright light source with low spatial coherence. Random lasers are shown by our latest work to be uniquely suited for parallel OCT and represent a new kind of light source for coherent optical imaging. Our research therefore has two main aims. First, we will develop a novel edge-emitting semiconductor random laser with low spatial coherence. We recently demonstrated that specifically designed random lasers are simultaneously bright, broadband, and exhibit low spatially coherence. These proof-of-concept demonstrations were performed using dye-based random lasers. However, dye-based lasers have well-known drawbacks that limit their widespread use in medicine. On the other hand, semiconductor light sources are compact, lightweight, and energy efficient, making them ubiquitous in clinical medicine. By applying the design principles we identified in our dye laser research, we will develop an electrically pumped, edge-emitting broadband semiconductor random laser operating at 800 nm, a major OCT wavelength. The laser emission from the edge of the membrane will form a thin illumination strip that can be incorporated into a parallel line-field OCT system for high-speed, crosstalk free imaging. In addition to being a paradigm-shifting advance for OCT, our work has broad impact in using low spatial coherence lasers in biomedical imaging. Second, we will demonstrate parallel spectral domain OCT using a random laser and validate crosstalk rejection. The edge-emitting random laser will enable line-field parallel imaging in which depth reflectivity profiles re recorded from an entire line on the sample in a single snapshot. The spectral domain OCT system will use a high-speed imaging spectrometer in its detector arm. The ability of the system to reject crosstalk will be validated in a series of phantom imaging experiments. The OCT system developed here will serve as a prototype upon which future translational research will be developed.

描述(申请人提供)：光学相干断层扫描(OCT)能够进行高速、微米级的横断面成像，已经改变了眼科医学，并具有改变心血管、胃肠、肺部和皮肤科医学的潜力。目前的OCT系统使用栅格扫描，这是一种连续方法，用于获取样品上不同位置的深度反射率分布。将模式从串行式OCT转换为并行式OCT将实现显著更高的成像速率。更高的成像速率将使人们能够全面量化以前无法接触到的疾病状态，包括(A)囊性纤维化的粘液流速和纤毛运动动力学，以及(B)在表皮分化障碍中对新药治疗的反应。实现平行OCT的缺失组件是空间相干性低的明亮光源。我们的最新工作表明，随机激光器是唯一适合于平行OCT的光源，它代表了一种用于相干光学成像的新光源。因此，我们的研究有两个主要目的。首先，我们将研制一种新型的低空间相干性边缘发射半导体随机激光器。我们最近证明，专门设计的随机激光器同时具有明亮、宽带和低空间相干性。这些概念验证演示是使用基于染料的随机激光进行的。然而，染料激光有众所周知的缺点，限制了它们在医学上的广泛使用。另一方面，半导体光源体积小、重量轻、节能，在临床医学中无处不在。通过应用我们在染料激光器研究中确定的设计原则，我们将开发一种电抽运、边缘发射的宽带半导体随机激光器，其工作波长为800 nm，这是OCT的主要波长。从薄膜边缘发出的激光将形成一条薄的照明带，可以并入平行的线场OCT系统中，以实现高速、无串扰的成像。除了是OCT范式转换的进步，我们的工作在使用低空间相干性激光在生物医学成像方面也有广泛的影响。其次，我们将使用随机激光器演示平行谱域OCT，并验证串扰抑制。边缘发射的随机激光将实现线场并行成像，其中在单次快照中记录样品上整条线的深度反射率分布。光谱域OCT系统将在其探测器臂中使用高速成像光谱仪。该系统抑制串扰的能力将在一系列体模成像实验中得到验证。这里开发的OCT系统将作为未来翻译研究的原型。