Development of a new light source for parallel optical coherence tomograph

并行光学相干断层扫描仪新型光源的研制

• 批准号: 8583146
• 负责人: Hui Cao
• 金额: $ 23.31万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8583146
• 关键词: Air; Area; Biomedical Engineering; Blood Vessels; Cardiovascular system; Childhood; Clinical Medicine; Cystic Fibrosis; Dermatology; Development; Devices; Diagnosis; Disease; Dyes; Esophagus; Exhibits; Eye; Future; Generations; Grant; Image; Imaging Phantoms; Interdisciplinary Study; Lasers; Light; Lighting; Location; Lung; Medicine; Membrane; Methods; Morphologic artifacts; Motion; Mucous body substance; Optical Coherence Tomography; Optics; Organ; Outcome; Pharmaceutical Preparations; Physicians; Plague; Public Health; Pulmonology; Pump; Research; Research Project Grants; Sampling; Scanning; Scientist; Semiconductors; Series; Skin; Source; Speed; Surface; System; Translational Research; Validation; Work; arm; base; bioimaging; density; design; detector; gastrointestinal; new technology; novel; optical imaging; photonics; prevent; prototype; public health relevance; quantum; research study; response; two-dimensional

DESCRIPTION (provided by applicant): The ability of optical coherence tomography (OCT) to perform high-speed, micron-scale, cross-sectional imaging has transformed ophthalmic medicine and has the potential to transform cardiovascular, gastrointestinal, pulmonary, and dermatological medicine. Current OCT systems use raster scanning, a serial method for acquiring depth reflectivity profiles at different locations on a sample. Shifting the paradigm fro serial to parallel OCT will enable dramatically higher imaging rates. Higher imaging rates will enable the comprehensive quantification of previously inaccessible disease states including (a) mucus flow rates and ciliary motion dynamics in cystic fibrosis and (b) response to new drug treatments in disorders of epidermal differentiation. The missing component to enable parallel OCT is a bright light source with low spatial coherence. Random lasers are shown by our latest work to be uniquely suited for parallel OCT and represent a new kind of light source for coherent optical imaging. Our research therefore has two main aims. First, we will develop a novel edge-emitting semiconductor random laser with low spatial coherence. We recently demonstrated that specifically designed random lasers are simultaneously bright, broadband, and exhibit low spatially coherence. These proof-of-concept demonstrations were performed using dye-based random lasers. However, dye-based lasers have well-known drawbacks that limit their widespread use in medicine. On the other hand, semiconductor light sources are compact, lightweight, and energy efficient, making them ubiquitous in clinical medicine. By applying the design principles we identified in our dye laser research, we will develop an electrically pumped, edge-emitting broadband semiconductor random laser operating at 800 nm, a major OCT wavelength. The laser emission from the edge of the membrane will form a thin illumination strip that can be incorporated into a parallel line-field OCT system for high-speed, crosstalk free imaging. In addition to being a paradigm-shifting advance for OCT, our work has broad impact in using low spatial coherence lasers in biomedical imaging. Second, we will demonstrate parallel spectral domain OCT using a random laser and validate crosstalk rejection. The edge-emitting random laser will enable line-field parallel imaging in which depth reflectivity profiles re recorded from an entire line on the sample in a single snapshot. The spectral domain OCT system will use a high-speed imaging spectrometer in its detector arm. The ability of the system to reject crosstalk will be validated in a series of phantom imaging experiments. The OCT system developed here will serve as a prototype upon which future translational research will be developed.

描述（由申请人提供）：光学相干断层扫描（OCT）执行高速、微米级、横截面成像的能力已经改变了眼科医学，并有可能改变心血管、胃肠道、肺和皮肤病学医学。当前的OCT系统使用光栅扫描，这是一种用于在样品上的不同位置处获取深度反射率轮廓的串行方法。将范例从串行OCT转移到并行OCT将实现显著更高的成像速率。更高的成像速率将使得能够全面量化先前不可及的疾病状态，包括（a）囊性纤维化中的粘液流速和纤毛运动动力学和（B）表皮分化障碍中对新药治疗的响应。用于实现并行OCT的缺失组件是具有低空间相干性的亮光源。我们的最新工作表明，随机激光器是唯一适合于并行OCT，并代表了一种新的光源的相干光学成像。因此，我们的研究有两个主要目的。首先，我们将发展一种新颖的具有低空间相干性的边发射半导体随机激光器。我们最近证明，专门设计的随机激光器同时明亮，宽带，并表现出低空间相干性。这些概念验证演示使用基于染料的随机激光器进行。然而，染料激光器具有众所周知的缺点，限制了它们在医学中的广泛应用。另一方面，半导体光源紧凑、轻便、节能，使其在临床医学中无处不在。通过应用我们在染料激光器研究中确定的设计原则，我们将开发一种工作在800 nm（OCT的主要波长）的电泵浦、边缘发射宽带半导体随机激光器。来自膜的边缘的激光发射将形成薄的照明带，该照明带可以并入平行线场OCT系统中以用于高速、无串扰成像。除了是OCT的一个范式转变的进步，我们的工作在生物医学成像中使用低空间相干激光器具有广泛的影响。其次，我们将使用随机激光演示并行谱域OCT并验证串扰抑制。边缘发射随机激光器将实现线场平行成像，其中深度反射率分布在单个快照中从样品上的整条线重新记录。光谱域OCT系统将在其探测器臂中使用高速成像光谱仪。系统抑制串扰的能力将在一系列体模成像实验中得到验证。这里开发的OCT系统将作为一个原型，未来的转化研究将开发。