Limited Competition of the MAPP Research Network Data Coordinating Core (U01)

MAPP 研究网络数据协调核心（U01）的有限竞争

• 批准号: 8633276
• 负责人: J Richard Landis
• 金额: $ 349.94万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8633276
• 关键词: Address; Ancillary Study; Basic Science; Biological Markers; Biometry; Chronic Fatigue Syndrome; Chronic Prostatitis; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Collection; Communication; Consent Forms; Data; Data Analyses; Data Collection; Data Quality; Data Reporting; Database Management Systems; Development; Ensure; Epidemiologic Studies; Fibromyalgia; Fostering; Goals; Interstitial Cystitis; Investigation; Irritable Bowel Syndrome; Leadership; Logistics; Maintenance; Manuscripts; Molecular; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Online Systems; Outcome Measure; Pattern; Pelvic Pain; Pennsylvania; Phase; Phase II Clinical Trials; Preparation; Procedures; Process; Protocols documentation; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Risk Factors; Schedule; Science; Secure; Series; Services; Site; Specimen; Subgroup; Symptoms; Syndrome; System; Technology; Teleconferences; Tissues; Training; Translational Research; Universities; Update; Urology; Work; Writing; base; biobank; chronic pain; chronic pelvic pain; clinical epidemiology; computerized; data exchange; data management; design; experience; medical schools; meetings; multidisciplinary; neuroimaging; operation; planetary Atmosphere; programs; protocol development; public health relevance; quality assurance; research study; tool; urologic; web site; working group

1 This is an application from the Center for Clinical Epidemiology and Biostatistics (CCEB) at the 2 University of Pennsylvania Perelman School of Medicine to continue to serve as the Data 3 Coordinating Core (DCC) for the Multi-disciplinary Approach to the Study of Chronic Pelvic Pain 4 (MAPP) Research Network. This proposal brings together a highly experienced DCC team, 5 currently supporting the NIDDK's MAPP Research Network (http://www.mappnetwork.org), 6 including urology co-investigators with extensive expertise in chronic pelvic pain, chronic 7 prostatitis, and interstitial cystitis. The DCC will continue to provide biostatistical study design 8 and analysis support, comprehensive data management and research computing services for 9 ongoing and new protocols, selected Discovery Site projects, and close collaboration with the 10 Tissue Analysis & Technology Core (TATC). The specific aims of the DCC are to 1) provide 11 scientific leadership and coordination in the design and implementation of inter-disciplinary 12 research projects across the MAPP Research Network~ 2) provide biostatistical expertise in 13 research designs, outcome measures and analytical strategies for clinical and translational 14 research investigations of urologic chronic pelvic pain syndromes (UCPPS)~ 3) provide 15 comprehensive DCC administrative support for the MAPP Research Network, promoting effective 16 communications, coordinating teleconferences, meetings, working groups, and document 17 development and management~ 4) collaborate with the Tissue Analysis and Technology Core 18 (TATC) on best practices for data collection, specimen tracking and storage, as well as to 19 support technical processes between the DCC and TATC~ 5) promote network-wide quality 20 assurance standards, practices and tools, including a comprehensive, secure www-based data 21 management system (DMS) for collection and centralized storage of all multi-site study data~ 6) 22 support the MAPP Research Network Ancillary Projects, assisting in their design, as well as 23 implementing a process for the submission, review and development of ancillary studies~ 7) 24 establish a new MAPP Network Integrated Basic/Translational Science Working Group to develop 25 collaborative basic cellular and molecular scientific studies of UCPPS that are ancillary to current 26 network protocols and complementary to the network's overall study goals. The DCC will 27 continue to leverage their considerable biostatistical and scientific expertise, coordinating and 28 project leadership, as well as urological expertise, to promote DCC best practices for the ongoing 29 conduct of clinical and translational science research projects, and design and planning for MAPP 30 Phase II protocols within the MAPP Research Network.

1这是来自临床流行病学和生物统计学中心（CCEB）的申请， 2宾夕法尼亚大学佩雷尔曼医学院继续担任数据 3协调核心（DCC）的多学科方法来研究慢性盆腔疼痛 4（MAPP）研究网络。 该提案汇集了一个经验丰富的DCC团队， 5目前支持NIDDK的MAPP研究网络（http：www.mappnetwork.org）， 6名包括泌尿科合作研究者，他们在慢性盆腔疼痛、慢性 7例前列腺炎、间质性膀胱炎。 DCC将继续提供生物统计学研究设计 8和分析支持，全面的数据管理和研究计算服务， 9个正在进行的和新的协议，选定的发现网站项目，并与 10组织分析与技术核心（TATC）。 DCC的具体目标是：1）提供 11科学领导和协调跨学科的设计和实施 MAPP研究网络的12个研究项目~ 2）提供生物统计学专业知识， 13项临床和转化的研究设计、结果测量和分析策略 14项泌尿系统慢性盆腔疼痛综合征（UCPPS）的研究调查~ 3）提供了 15.发展协调委员会为废除贫穷、促进和平与进步运动研究网络提供全面的行政支助， 16次通信、协调电话会议、会议、工作组和文件 17开发和管理~ 4）与组织分析和技术核心合作 18（TATC）关于数据收集、标本跟踪和储存的最佳做法，以及 19支持DCC和TATC之间的技术流程~ 5）提高网络范围内的质量 20个保证标准、做法和工具，包括全面、安全的基于www的数据 21用于收集和集中存储所有多中心研究数据的管理系统（DMS）~ 6） 22个支持MAPP研究网络辅助项目，协助其设计，以及 23实施辅助研究的提交、审查和开发流程~ 7） 24建立一个新的MAPP网络综合基础/转化科学工作组， 25项UCPPS的基础细胞和分子科学研究， 26网络协议和网络的整体学习目标的补充。 DCC将 27个国家继续利用其丰富的生物统计和科学专门知识，协调和 28个项目的领导，以及泌尿专业知识，以促进DCC的最佳做法，为正在进行的 开展29项临床和转化科学研究项目，并为MAPP设计和规划 30 MAPP研究网络内的第二阶段协议。