Limited Competition of the MAPP Research Network Data Coordinating Core (U01)

这是临床流行病学和生物统计中心(CCEB)的一份申请 2宾夕法尼亚大学佩雷尔曼医学院继续担任数据 慢性盆腔疼痛多学科研究的协调核心(DCC) 4(MAPP)研究网络。这项提案汇集了一支经验丰富的DCC团队， 5目前支持NIDDK的MAPP研究网络(http://www.mappnetwork.org)， 6名包括在慢性盆腔疼痛、慢性盆腔疼痛和慢性盆腔疼痛方面具有丰富专业知识的泌尿外科合作调查员 7前列腺炎、间质性膀胱炎。疾病预防控制中心将继续提供生物统计学研究设计 8和分析支持、全面的数据管理和研究计算服务 9现有的和新的协议、选定的探索站点项目，以及与 10组织分析与技术核心(TATC)。DCC的具体目标是：1)提供 11在跨学科的设计和实施方面的科学领导和协调 MAPP研究网络中的12个研究项目~2)提供生物统计学方面的专门知识 用于临床和翻译的13项研究设计、结果测量和分析策略 14例泌尿系慢性盆腔疼痛综合征(UCPPS)~3研究报告 15为MAPP研究网络提供全面的DCC行政支持，促进有效 16通信、协调电话会议、会议、工作组和文件 17开发和管理~4)与组织分析和技术核心合作 18(TATC)关于数据收集、标本跟踪和储存的最佳做法以及 19)支持DCC和TATC之间的技术流程，促进全网质量 20保障标准、做法和工具，包括全面、安全的万维网数据 21用于收集和集中存储所有多站点研究数据的管理系统(DMS)~6) 22支持MAPP研究网络辅助项目，协助其设计，以及 23执行提交、审查和编写辅助研究报告的程序~7) 24建立新的MAPP网络综合基础/翻译科学工作组，以发展 25个UCPPS的协作性基础细胞和分子科学研究，这些研究是当前的辅助 26个网络协议，与网络的总体研究目标相辅相成。DCC将 27继续利用其丰富的生物统计和科学专长，协调和 28.项目领导以及泌尿科专业知识，以促进目前正在进行的 29进行临床和转化科学研究项目，并为MAPP进行设计和规划 30 MAPP研究网络内的第二阶段协议。

1 This is an application from the Center for Clinical Epidemiology and Biostatistics (CCEB) at the 2 University of Pennsylvania Perelman School of Medicine to continue to serve as the Data 3 Coordinating Core (DCC) for the Multi-disciplinary Approach to the Study of Chronic Pelvic Pain 4 (MAPP) Research Network. This proposal brings together a highly experienced DCC team, 5 currently supporting the NIDDK's MAPP Research Network (http://www.mappnetwork.org), 6 including urology co-investigators with extensive expertise in chronic pelvic pain, chronic 7 prostatitis, and interstitial cystitis. The DCC will continue to provide biostatistical study design 8 and analysis support, comprehensive data management and research computing services for 9 ongoing and new protocols, selected Discovery Site projects, and close collaboration with the 10 Tissue Analysis & Technology Core (TATC). The specific aims of the DCC are to 1) provide 11 scientific leadership and coordination in the design and implementation of inter-disciplinary 12 research projects across the MAPP Research Network~ 2) provide biostatistical expertise in 13 research designs, outcome measures and analytical strategies for clinical and translational 14 research investigations of urologic chronic pelvic pain syndromes (UCPPS)~ 3) provide 15 comprehensive DCC administrative support for the MAPP Research Network, promoting effective 16 communications, coordinating teleconferences, meetings, working groups, and document 17 development and management~ 4) collaborate with the Tissue Analysis and Technology Core 18 (TATC) on best practices for data collection, specimen tracking and storage, as well as to 19 support technical processes between the DCC and TATC~ 5) promote network-wide quality 20 assurance standards, practices and tools, including a comprehensive, secure www-based data 21 management system (DMS) for collection and centralized storage of all multi-site study data~ 6) 22 support the MAPP Research Network Ancillary Projects, assisting in their design, as well as 23 implementing a process for the submission, review and development of ancillary studies~ 7) 24 establish a new MAPP Network Integrated Basic/Translational Science Working Group to develop 25 collaborative basic cellular and molecular scientific studies of UCPPS that are ancillary to current 26 network protocols and complementary to the network's overall study goals. The DCC will 27 continue to leverage their considerable biostatistical and scientific expertise, coordinating and 28 project leadership, as well as urological expertise, to promote DCC best practices for the ongoing 29 conduct of clinical and translational science research projects, and design and planning for MAPP 30 Phase II protocols within the MAPP Research Network.