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中文摘要
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项目摘要 这一关于U24赠款的行政补充的建议, 多学科方法研究慢性盆腔疼痛(MAPP)研究网络数据 协调核心(DCC)由DCC提交给MAPP研究网络(MAPP-RN), 宾夕法尼亚大学佩雷尔曼医学院DCC团队将提供额外的 服务超出目前资助的DCC为MAPP研究网络,以支持新的 本预算年度第14年(BY 14)的具体目标1-5。临床数据、文件和 将提供来自MAPP I EPS和MAPP II SPS的生物标本资源的描述 通过重新设计的MAPP网站(具体目标1)进行“面向公众”的探索,以及全新的 MAPP DataView工具包(具体目标3),用于数据可视化和进行比较 在广泛的EPS和SPS队列数据之间和内部进行分析,并进行高级 在选定的亚组内进行分析,通过汇总这两个亚组之间的对齐数据进行汇总, 队列研究除了在EPS和SPS之间实施最终数据管理和协调外, 队列数据,DCC将准备广泛的文件,同时发布在新的MAPP上 网站和存款到NIDDK存储库(具体目标2)。此外,DCC将准备 研讨会材料和主办MAPP DataView研讨会,促进MAPP数据用于新的研究 (四)具体目标。为调查人员和研究小组设计的教育材料, 最大限度地利用这些数据资源,并执行专门的统计程序 (用于基线亚组发现的共识聚类,使用 总体缓解评估(GRA)评分和症状变化水平,纵向功能 结果亚组发现的聚类)应用于MAPP II SPS数据将被强调。在 特别是,DCC将使用全球反应评估(GRA)、骨盆 MAPP II SPS中提供的疼痛严重程度(PPS)和泌尿系统症状严重程度(USS)特征, 确定与PPS和USS症状特征同时改善相关的因素, 仅在PPS中改善、仅在USS中改善或PPS和USS均未改善的患者(具体目标5)。
英文摘要
Project Summary This proposal for an Administrative Supplement to the U24 grant for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Data Coordinating Core (DCC) is being submitted by the DCC for the MAPP Research Network (MAPP-RN) at the University of Pennsylvania Perelman School of Medicine. The DCC team will provide additional services beyond those currently funded as the DCC for the MAPP Research Network, in support of new Specific Aims 1-5 during the current budget year 14 (BY14). The clinical data, documentation and descriptions of the biospecimen resources from the MAPP I EPS and MAPP II SPS will be made accessible for “public facing” exploration via a re-engineered MAPP website (Specific Aim 1), together with a totally new MAPP DataView toolkit (Specific Aim 3) designed for data visualization and for the conduct of comparative analyses between, and within, the extensive EPS and SPS cohort data, as well as to conduct advanced analyses within selected subgroups assembled by aggregating aligned data across both of these two cohort studies. In addition to implementing final data curation and harmonization across the EPS and SPS cohort data, the DCC will prepare extensive documentation for simultaneous posting on the new MAPP website and for deposit to the NIDDK Repository (Specific Aim 2). Furthermore, the DCC will prepare workshop materials and host MAPP DataView workshops, promoting MAPP data use for new research investigations (Specific Aim 4). Educational materials designed for investigators and research teams to maximize the utility of these data resources and to implement specialized statistical procedures (consensus clustering for baseline subgroup discovery, quantifying clinically meaningful change utilizing Global Response Assessment (GRA) scores and levels of symptom change, longitudinal functional clustering for outcome subgroup discovery) applied to MAPP II SPS data will be emphasized. In particular, the DCC will prepare longitudinal analyses using the Global Response Assessment (GRA), Pelvic Pain Severity (PPS) and Urinary Symptoms Severity (USS) profiles available within the MAPP II SPS to identify factors associated with simultaneous improvement in both PPS and USS symptom profiles, in contrast to patients that improve only in PPS, only in USS, or in neither of PPS or USS (Specific Aim 5).
期刊论文(48)
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会议论文
DOI: 10.1080/01621459.2022.2066536
发表时间: 2022
期刊: Journal of the American Statistical Association
影响因子: 3.7
作者: []
通讯作者:
DOI: 10.1111/ner.13512
发表时间: 2023-07
期刊: Neuromodulation : journal of the International Neuromodulation Society
影响因子: --
作者: [Lim M, Kim DJ, Nascimento TD, Ichesco E, Kaplan C, Harris RE, DaSilva AF]
通讯作者: DaSilva AF
DOI: 10.1097/ju.0000000000002438
发表时间: 2022-06
期刊: JOURNAL OF UROLOGY
影响因子: 6.6
作者: [Naliboff, Bruce D., Locke, Kenneth, Jr., Schrepf, Andrew D., Griffith, James W., Moldwin, Robert, Krieger, John N., Rodriguez, Larissa V., Clemens, J. Quentin, Lai, H. Henry, Sutcliffe, Siobhan, Taple, Bayley J., Williams, David, Pontari, Michael A., Mullins, Chris, Landis, J. Richard]
通讯作者: Landis, J. Richard
DOI: 10.1097/ju.0000000000001391
发表时间: 2021-03
期刊: The Journal of urology
影响因子: --
作者: [Roy R, Stephens AJ, Daisy C, Merritt L, Newcomb CW, Yang J, Dagher A, Curatolo A, Sachdev M, McNeish B, Landis R, van Bokhoven A, El-Hayek A, Froehlich J, Pontari MA, Zurakowski D, Lee RS, Moses MA]
通讯作者: Moses MA
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    MAPP research network
    • 批准号:
      7901948
    • 项目类别:
    • 资助金额:
      $40.01万
    • 财政年份:
      2009
    • 负责人:
      J Richard Landis
    • 依托单位:
    MAPP Research Network
    • 批准号:
      8775981
    • 项目类别:
    • 资助金额:
      $115.0万
    • 财政年份:
      2008
    • 负责人:
      J Richard Landis
    • 依托单位:
    Limited Competition for Continuation of the MAPP-RN DCC
    • 批准号:
      10204778
    • 项目类别:
    • 资助金额:
      $133.4万
    • 财政年份:
      2008
    • 负责人:
      J Richard Landis
    • 依托单位:
    MAPP research network
    • 批准号:
      7929001
    • 项目类别:
    • 资助金额:
      $135.42万
    • 财政年份:
      2008
    • 负责人:
      J Richard Landis
    • 依托单位:
    海外基金