Limited Competition for Continuation of the MAPP-RN DCC

项目摘要 这项关于U24补助金的行政补编的建议将继续 慢性盆腔疼痛研究的多学科方法(MAPP)研究网络数据 协调核心(DCC)由DCC为MAPP研究网络(MAPP-RN)提交，地址为 宾夕法尼亚大学佩雷尔曼医学院。DCC团队将提供额外的 除了目前作为MAPP研究网络DCC资助的服务，以支持新的 本预算年度(到2014年)的具体目标1-5。临床数据、文件和 将提供来自MAPP I EPS和MAPP II SPS的生物群落资源的说明 通过重新设计的Mapp网站(特定目标1)和一个全新的 Mapp DataView工具包(特定目标3)专为数据可视化和进行比较而设计 在广泛的EPS和SPS队列数据之间和内部进行分析，以及进行高级 选定子组内的分析通过聚合这两个子组中的对齐数据进行组合 队列研究。除了在EPS和SPS之间实施最终数据管理和协调之外 队列数据，DCC将准备广泛的文档，以便同时在新的MAPP上发布 网站并存入NIDDK储存库(具体目标2)。此外，DCC将准备 研讨会材料和主办Mapp DataView研讨会，促进Mapp数据用于新研究 调查(具体目标4)。为调查人员和研究团队设计的教育材料 最大限度地利用这些数据资源并执行专门的统计程序 (用于基线亚组发现的共识聚类，量化具有临床意义的变化 全球反应评估(GRA)评分和症状变化水平，纵向功能 将强调应用于MAPP II SPS数据的结果分组发现)。在……里面 特别是，DCC将使用全球反应评估(GRA)准备纵向分析，骨盆 MAPP II SPS中提供的疼痛严重程度(PPS)和尿路症状严重程度(USS)配置文件可用于 相比之下，确定与PPS和USS症状特征同时改善相关的因素 对于仅在PPS、仅在USS、或在PPS和USS中都没有改善的患者(特定目标5)。

Project Summary This proposal for an Administrative Supplement to the U24 grant for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Data Coordinating Core (DCC) is being submitted by the DCC for the MAPP Research Network (MAPP-RN) at the University of Pennsylvania Perelman School of Medicine. The DCC team will provide additional services beyond those currently funded as the DCC for the MAPP Research Network, in support of new Specific Aims 1-5 during the current budget year 14 (BY14). The clinical data, documentation and descriptions of the biospecimen resources from the MAPP I EPS and MAPP II SPS will be made accessible for “public facing” exploration via a re-engineered MAPP website (Specific Aim 1), together with a totally new MAPP DataView toolkit (Specific Aim 3) designed for data visualization and for the conduct of comparative analyses between, and within, the extensive EPS and SPS cohort data, as well as to conduct advanced analyses within selected subgroups assembled by aggregating aligned data across both of these two cohort studies. In addition to implementing final data curation and harmonization across the EPS and SPS cohort data, the DCC will prepare extensive documentation for simultaneous posting on the new MAPP website and for deposit to the NIDDK Repository (Specific Aim 2). Furthermore, the DCC will prepare workshop materials and host MAPP DataView workshops, promoting MAPP data use for new research investigations (Specific Aim 4). Educational materials designed for investigators and research teams to maximize the utility of these data resources and to implement specialized statistical procedures (consensus clustering for baseline subgroup discovery, quantifying clinically meaningful change utilizing Global Response Assessment (GRA) scores and levels of symptom change, longitudinal functional clustering for outcome subgroup discovery) applied to MAPP II SPS data will be emphasized. In particular, the DCC will prepare longitudinal analyses using the Global Response Assessment (GRA), Pelvic Pain Severity (PPS) and Urinary Symptoms Severity (USS) profiles available within the MAPP II SPS to identify factors associated with simultaneous improvement in both PPS and USS symptom profiles, in contrast to patients that improve only in PPS, only in USS, or in neither of PPS or USS (Specific Aim 5).