MAPP research network

MAPP研究网络

• 批准号: 8145035
• 负责人: J Richard Landis
• 金额: $ 6.5万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145035
• 关键词: Ancillary Study; Behavioral; Behavioral Genetics; Biometry; Chronic Fatigue Syndrome; Chronic Prostatitis; Clinical; Clinical Research; Clinical Trials; Collection; Communication; Data; Data Collection; Database Management Systems; Databases; Development; Fibromyalgia; Functional disorder; Funding; Future; Goals; Human Resources; Informatics; Interstitial Cystitis; Irritable Bowel Syndrome; Laboratories; Lead; Leadership; Link; Medical center; Medicine; Methods; Migraine; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Outcome Measure; Pain; Pathology; Patients; Pelvic Pain; Pennsylvania; Prevention; Process; Protocols documentation; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Scientist; Secure; Series; Services; Site; Specimen; Syndrome; System; Technology; Tissues; Translational Research; Universities; Vulvodynia; Work; chronic pain; chronic pelvic pain; clinical epidemiology; cohort; data integration; data management; design; disease phenotype; experience; implementation research; medical schools; meetings; programs; quality assurance; tool; treatment strategy; urologic; working group

DESCRIPTION (provided by applicant): This is an application from the Center for Clinical Epidemiology and Biostatistics (CCEB) at the University of Pennsylvania Medical Center to serve as the Data Coordination Core (DCC) for the Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. This proposal brings together a highly experienced team of DCC personnel, currently supporting the Urological Pelvic Pain Collaborative Research Network (UPPCRN) (http://www.cceb.med.upenn.edu/uppcrn) (2003-2008), as well as co-investigators with extensive expertise in chronic pelvic pain, chronic prostatitis, interstitial cystitis and laboratory and pathology medicine, who have worked together over the past 10-15 years within a productive series of NIDDK-funded urological collaborative research networks; in particular, the DCC for the Interstitial Cystitis Data Base (ICDB) Study (1993-1998), the CPCRN (1997-2003) and the ICCTG (1998-2004). The DCC will provide biostatistical study design/analysis support and comprehensive data management and research computing services for each multi-site study, as well as selected Discovery Site projects, collaborating closely with the Tissue Analysis & Technology Core (TATC) Laboratory. The specific aims of the DCC are to 1) facilitate conduct of multi-disciplinary basic and translational research, by providing scientific leadership in the design and implementation of research projects across the MAPP Research Network; 2) provide biostatistical expertise in research design, outcome measures and analytic strategies for translational and clinical investigations of pelvic pain syndromes; 3) promote network-wide quality assurance standards, practices and tools, including a comprehensive, secure www-based data management system (DMS) for collection and centralized storage of all study data; 4) collaborate with the Tissue Analysis and Technology Core (TATC) Laboratory on best practices for data collection, specimen tracking and storage, as well as support technical processes between the DCC and TATC; 5) provide comprehensive administrative DCC support for the MAPP Research Network, promoting effective communications, coordinating meetings, working groups, document management and distribute study proceedings; 6) support MAPP Research Network Ancillary Projects, assisting in their design, as well as implementing a process for the submission, review and development of ancillary studies. The DCC will leverage their considerable CTSA informatics expertise and resources to promote best practices for data integration methods, and tools in support of the clinical and translational science research projects within the MAPP Research Network. The Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network of diverse clinicians and scientists will investigate a wide variety of factors that may cause urologic pelvic pain and and related pain syndromes. The objective is to discover information that will lead to the development of future prevention and treatment strategies. This research method involves many different kinds of scientific approaches and may add new information to a variety of clinical syndromes.

描述（由申请人提供）：这是一份来自宾夕法尼亚大学医学中心临床流行病学和生物统计学中心（CCEB）的申请，作为慢性盆腔疼痛多学科研究方法（MAPP）研究网络的数据协调核心（DCC）。该提案汇集了一个经验丰富的DCC人员团队，目前支持泌尿盆腔疼痛合作研究网络（upppcrn） （http://www.cceb.med.upenn.edu/uppcrn）（2003-2008），以及在慢性盆腔疼痛，慢性前列腺炎，间质性膀胱炎和实验室和病理医学方面具有广泛专业知识的共同研究者。在过去的10-15年中，他们在niddk资助的一系列富有成效的泌尿学合作研究网络中共同工作；特别是间质性膀胱炎数据库（ICDB）研究（1993-1998）、CPCRN（1997-2003）和ICCTG（1998-2004）的DCC。DCC将与组织分析与技术核心实验室（TATC）密切合作，为每个多地点研究以及选定的发现地点项目提供生物统计研究设计/分析支持、全面的数据管理和研究计算服务。DCC的具体目标是：1)通过在MAPP研究网络的研究项目的设计和实施方面提供科学领导，促进多学科基础和转化研究的开展；2)为盆腔疼痛综合征的转化和临床研究提供研究设计、结果测量和分析策略方面的生物统计学专业知识；3)推广全网络的质量保证标准、实践和工具，包括一个全面、安全的基于www的数据管理系统（DMS），用于收集和集中存储所有研究数据；4)与组织分析和技术核心（TATC）实验室就数据收集、标本跟踪和存储的最佳实践进行合作，并支持DCC和TATC之间的技术流程；5)为MAPP研究网络提供全面的行政DCC支持，促进有效的沟通、协调会议、工作组、文件管理和分发研究记录；6)支持MAPP研究网络辅助项目，协助其设计，并实施辅助研究的提交、审查和开发流程。DCC将利用其丰富的CTSA信息学专业知识和资源，促进数据集成方法和工具的最佳实践，以支持MAPP研究网络内的临床和转化科学研究项目。